SZGR2

Summary ?

GeneID	818
Symbol	CAMK2G
Synonyms	CAMK\|CAMK-II\|CAMKG
Description	calcium/calmodulin-dependent protein kinase II gamma
Reference	MIM:602123\|HGNC:HGNC:1463\|Ensembl:ENSG00000148660\|HPRD:03672\|Vega:OTTHUMG00000018492
Gene type	protein-coding
Map location	10q22
Pascal p-value	0.601
Sherlock p-value	0.214
Fetal beta	-0.991
DMG	2 (# studies)
eGene	Nucleus accumbens basal ganglia Myers' cis & trans
Support	INTRACELLULAR SIGNAL TRANSDUCTION SEROTONIN G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_clathrin G2Cdb.human_Synaptosome G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	3
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	3
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.1968

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg10168709	10	75599394	CAMK2G	5.02E-6	0.547	0.01	DMG:Wockner_2014
cg06022113	10	75616203	CAMK2G	9.09E-5	0.405	0.027	DMG:Wockner_2014
cg19287139	10	75634631	CAMK2G	2.09E-8	-0.019	7.15E-6	DMG:Jaffe_2016

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs9571716	chr13	67711344	CAMK2G	818		0.19		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
GNG5	0.74	0.67
HMG20B	0.71	0.63
TP53I13	0.70	0.71
PECI	0.69	0.61
TGIF1	0.69	0.42
RFXANK	0.69	0.54
PAX6	0.69	0.65
CLIC1	0.67	0.45
CDKN2C	0.65	0.72
AKR7A2	0.64	0.62

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
CACNA1A	-0.39	-0.47
ARHGAP20	-0.38	-0.48
FBXW7	-0.38	-0.46
DOCK9	-0.37	-0.47
HIVEP2	-0.36	-0.49
LRFN2	-0.36	-0.47
RALYL	-0.36	-0.54
RTN4RL1	-0.36	-0.46
FRMPD4	-0.35	-0.43
MEF2C	-0.35	-0.48

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0005516	calmodulin binding	NAS		9060999
GO:0005524	ATP binding	IEA		-
GO:0005524	ATP binding	NAS		-
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	NAS		9060999
GO:0004674	protein serine/threonine kinase activity	IEA		-
GO:0004683	calmodulin-dependent protein kinase activity	IEA		-
GO:0016740	transferase activity	IEA		-
GO:0016301	kinase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000082	G1/S transition of mitotic cell cycle	IEA		-
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0006468	protein amino acid phosphorylation	NAS		-
GO:0007165	signal transduction	NAS		8449910
GO:0006816	calcium ion transport	IEA		-
GO:0030073	insulin secretion	NAS		9240463
GO:0046777	protein amino acid autophosphorylation	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005575	cellular_component	ND		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG ERBB SIGNALING PATHWAY	87	71	All SZGR 2.0 genes in this pathway
KEGG CALCIUM SIGNALING PATHWAY	178	134	All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS	114	79	All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY	151	112	All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION	70	57	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
KEGG OLFACTORY TRANSDUCTION	389	85	All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY	101	77	All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS	102	80	All SZGR 2.0 genes in this pathway
KEGG GLIOMA	65	56	All SZGR 2.0 genes in this pathway
BIOCARTA BIOPEPTIDES PATHWAY	45	35	All SZGR 2.0 genes in this pathway
BIOCARTA CACAM PATHWAY	16	11	All SZGR 2.0 genes in this pathway
BIOCARTA PGC1A PATHWAY	26	20	All SZGR 2.0 genes in this pathway
BIOCARTA STATHMIN PATHWAY	19	17	All SZGR 2.0 genes in this pathway
BIOCARTA CREB PATHWAY	27	25	All SZGR 2.0 genes in this pathway
ST WNT CA2 CYCLIC GMP PATHWAY	20	14	All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY	65	50	All SZGR 2.0 genes in this pathway
PID IFNG PATHWAY	40	34	All SZGR 2.0 genes in this pathway
PID NCADHERIN PATHWAY	33	32	All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN	180	101	All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING UP	176	123	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN	378	231	All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP	239	157	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN	800	473	All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS	1174	695	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
JOHANSSON BRAIN CANCER EARLY VS LATE DN	45	35	All SZGR 2.0 genes in this pathway
SHIPP DLBCL CURED VS FATAL DN	45	30	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS DN	40	31	All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM DN	86	66	All SZGR 2.0 genes in this pathway
ULE SPLICING VIA NOVA2	43	38	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP	148	96	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP	578	341	All SZGR 2.0 genes in this pathway
AMBROSINI FLAVOPIRIDOL TREATMENT TP53	109	63	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN UP	56	38	All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION	456	287	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA NEURAL	129	85	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 DN	88	61	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY	1839	928	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-10	1698	1704	m8	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	1698	1704	m8	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-103/107	1115	1121	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
				hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
				hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
				hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-153	1067	1073	m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-181	1935	1941	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-194	1962	1968	1A	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-219	1232	1238	m8	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-29	684	690	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
				hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-324-5p	767	773	1A	hsa-miR-324-5p	CGCAUCCCCUAGGGCAUUGGUGU
miR-33	774	780	m8	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
				hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
				hsa-miR-33	GUGCAUUGUAGUUGCAUUG
				hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-338	1227	1233	1A	hsa-miR-338^brain	UCCAGCAUCAGUGAUUUUGUUGA
miR-495	1960	1966	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-495	1960	1966	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-543	1936	1942	m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-544	690	696	m8	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU
miR-544	690	696	m8	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CAMK2G