Gene Page: CDC20

Summary
GeneID  991
Symbol  CDC20
Synonyms  CDC20A|MGC102824|bA276H19.3|p55CDC
Description  cell division cycle 20 homolog (S. cerevisiae)
See related  HGNC:1723|MIM:603618|Ensembl:ENSG00000117399|HPRD:04686|
Locus tag  -
Gene type  protein-coding
Map location  1p34.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0167 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SLC25A460.900.90
PJA20.890.91
SLC30A90.890.90
C5orf220.890.90
PPP6C0.890.90
ACTR20.890.90
IPO110.890.91
OPA10.890.90
KIAA10120.880.90
CUL50.880.91
Top 10 negatively co-expressed genes
HIGD1B-0.65-0.66
FXYD1-0.64-0.66
GSDMD-0.62-0.65
MT-CO2-0.62-0.62
AF347015.21-0.60-0.59
IFI27-0.60-0.64
AF347015.2-0.60-0.58
AF347015.33-0.59-0.60
AF347015.8-0.59-0.60
AC098691.2-0.59-0.61
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11030144 |14743218 |17353931 
|17719540 |18022367 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006511ubiquitin-dependent protein catabolic processTAS9682218 
GO:0007049cell cycleTAS9682218 
GO:0007067mitosisIEA-
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processEXP11285280 
GO:0051301cell divisionIEA-
GO:0051436negative regulation of ubiquitin-protein ligase activity during mitotic cell cycleEXP14593737 
GO:0051437positive regulation of ubiquitin-protein ligase activity during mitotic cell cycleEXP12791267 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005819spindleTAS7513050 
GO:0005829cytosolEXP11285280 |11535616 |11742988 
|12070128 |15469984 
GO:0005654nucleoplasmEXP12791267 |15469984 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANAPC5APC5anaphase promoting complex subunit 5Reconstituted ComplexBioGRID12956947 
ANAPC7APC7anaphase promoting complex subunit 7Reconstituted ComplexBioGRID12956947 
APCBTPS2 | DP2 | DP2.5 | DP3 | GSadenomatous polyposis coli-HPRD9637688 |9811605 
AURKAAIK | ARK1 | AURA | AURORA2 | BTAK | MGC34538 | STK15 | STK6 | STK7aurora kinase A-HPRD,BioGRID10377410 
BUB1BUB1A | BUB1L | hBUB1budding uninhibited by benzimidazoles 1 homolog (yeast)Bub1 interacts with Cdc20.BIND15525512 
BUB1BBUB1beta | BUBR1 | Bub1A | MAD3L | SSK1 | hBUBR1budding uninhibited by benzimidazoles 1 homolog beta (yeast)BubR1 interacts with Cdc20.BIND15525512 
-HPRD,BioGRID11030144 |11274370 
|11535616 |11907259 
CCDC59BR22 | DKFZp686K1021 | FLJ10294 | HSPC128 | TAP26coiled-coil domain containing 59Affinity Capture-MSBioGRID17353931 
CCNA2CCN1 | CCNAcyclin A2-HPRD,BioGRID10679238 
CCNB1CCNBcyclin B1Cyclin B interacts with Cdc20.BIND15916961 
CDC16APC6cell division cycle 16 homolog (S. cerevisiae)-HPRD,BioGRID9628895 |12196507 
CDC27APC3 | CDC27Hs | D0S1430E | D17S978E | HNUCcell division cycle 27 homolog (S. cerevisiae)Affinity Capture-Western
Reconstituted Complex		BioGRID9628895 |9736712 
|9811605 |12196507 
|12956947 |14561775 
-HPRD9736712 |12196507 
FBXO5EMI1 | FBX5 | Fbxo31F-box protein 5-HPRD,BioGRID11389834 |11976684 
|11988738 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1Affinity Capture-Western
Co-purification		BioGRID15388328 
HDAC2RPD3 | YAF1histone deacetylase 2Affinity Capture-Western
Co-purification		BioGRID15388328 
KRT31HA1 | Ha-1 | KRTHA1 | MGC138630 | hHa1keratin 31Affinity Capture-MSBioGRID17353931 
KRT32HA2 | HKA2 | KRTHA2 | hHa2keratin 32Affinity Capture-MSBioGRID17353931 
KRT33AHA3I | Ha-3I | KRTHA3A | Krt1-3 | hHa3-Ikeratin 33AAffinity Capture-MSBioGRID17353931 
KRT85HB5 | Hb-5 | KRTHB5 | hHb5keratin 85Affinity Capture-MSBioGRID17353931 
KRTAP19-5KAP19.5keratin associated protein 19-5Affinity Capture-MSBioGRID17353931 
KRTAP9-2KAP9.2 | KRTAP9.2 | MGC130013keratin associated protein 9-2Affinity Capture-MSBioGRID17353931 
KRTAP9-3KAP9.3 | KRTAP9.3keratin associated protein 9-3Affinity Capture-MSBioGRID17353931 
MAD2L1HSMAD2 | MAD2MAD2 mitotic arrest deficient-like 1 (yeast)-HPRD9628895 |9637688 
|9736712 |10700282 
|11804586 
MAD2 interacts with p55CDC.BIND12456649 
MAD2L1 (Mad2) interacts with Cdc20.BIND15694304 
Mad2 interacts with Cdc20.BIND15525512 
Affinity Capture-Western
Co-crystal Structure
Reconstituted Complex
Two-hybrid		BioGRID9628895 |9637688 
|9736712 |10700282 
|11438673 |11707408 
|12196507 |14561775 
|14607335 
MAD2L2MAD2B | REV7MAD2 mitotic arrest deficient-like 2 (yeast)Reconstituted ComplexBioGRID11459826 
PTTG1EAP1 | HPTTG | MGC126883 | MGC138276 | PTTG | TUTR1pituitary tumor-transforming 1-HPRD11553328 
Securin interacts with Cdc20. This interaction was modelled on a demonstrated interaction between human Securin and Xenopus Cdc20.BIND15916961 
SOSTDC1CDA019 | DKFZp564D206 | ECTODIN | USAG1sclerostin domain containing 1-HPRD15280373 
SPATC1MGC61633 | SPATA15 | SPERIOLINspermatogenesis and centriole associated 1-HPRD,BioGRID15280373 
YARS2CGI-04 | FLJ13995 | TYRRS | mt-TyrRStyrosyl-tRNA synthetase 2, mitochondrialAffinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_CYCLE 12884All SZGR genes in this pathway
KEGG_OOCYTE_MEIOSIS 11479All SZGR genes in this pathway
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 13898All SZGR genes in this pathway
PID_PLK1_PATHWAY 4625All SZGR genes in this pathway
REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS 2412All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_CELL_CYCLE_CHECKPOINTS 12470All SZGR genes in this pathway
REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 8546All SZGR genes in this pathway
REACTOME_MITOTIC_M_M_G1_PHASES 17298All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 7238All SZGR genes in this pathway
REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS 7340All SZGR genes in this pathway
REACTOME_MITOTIC_PROMETAPHASE 8751All SZGR genes in this pathway
REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B 2610All SZGR genes in this pathway
REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1 5132All SZGR genes in this pathway
REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE 229All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 212129All SZGR genes in this pathway
REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A 2812All SZGR genes in this pathway
NAKAMURA_CANCER_MICROENVIRONMENT_DN 4629All SZGR genes in this pathway
SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP 15184All SZGR genes in this pathway
WILCOX_RESPONSE_TO_PROGESTERONE_UP 15290All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_DN 310188All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_DN 244153All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_UP 290177All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_DN 5325All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_DN 13976All SZGR genes in this pathway
ODONNELL_TARGETS_OF_MYC_AND_TFRC_DN 4525All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
ELVIDGE_HYPOXIA_DN 14694All SZGR genes in this pathway
GRAHAM_CML_QUIESCENT_VS_NORMAL_QUIESCENT_UP 8745All SZGR genes in this pathway
GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_UP 181101All SZGR genes in this pathway
GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_DN 8749All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_DN 172112All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
TANG_SENESCENCE_TP53_TARGETS_DN 5733All SZGR genes in this pathway
JOHANSSON_GLIOMAGENESIS_BY_PDGFB_UP 5844All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_6_7WK_DN 7954All SZGR genes in this pathway
KONG_E2F3_TARGETS 9758All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER 14073All SZGR genes in this pathway
WAESCH_ANAPHASE_PROMOTING_COMPLEX 127All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
KORKOLA_TERATOMA 3925All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1 229137All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
PUJANA_XPRSS_INT_NETWORK 168103All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
PUJANA_BRCA_CENTERED_NETWORK 11772All SZGR genes in this pathway
WILLIAMS_ESR1_TARGETS_UP 2616All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
SCIAN_CELL_CYCLE_TARGETS_OF_TP53_AND_TP73_DN 2214All SZGR genes in this pathway
BENPORATH_ES_1 379235All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
MORI_PRE_BI_LYMPHOCYTE_UP 8054All SZGR genes in this pathway
MORI_LARGE_PRE_BII_LYMPHOCYTE_UP 8649All SZGR genes in this pathway
MORI_IMMATURE_B_LYMPHOCYTE_DN 9055All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN 200112All SZGR genes in this pathway
SHEPARD_BMYB_TARGETS 7441All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_DN 185111All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
LE_EGR2_TARGETS_UP 10875All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_DN 163115All SZGR genes in this pathway
ALCALAY_AML_BY_NPM1_LOCALIZATION_DN 184132All SZGR genes in this pathway
HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_DN 6341All SZGR genes in this pathway
LEE_AGING_NEOCORTEX_DN 8049All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_H2O2 3929All SZGR genes in this pathway
PAL_PRMT5_TARGETS_UP 203135All SZGR genes in this pathway
KANG_DOXORUBICIN_RESISTANCE_UP 5433All SZGR genes in this pathway
RHODES_UNDIFFERENTIATED_CANCER 6944All SZGR genes in this pathway
BURTON_ADIPOGENESIS_3 10164All SZGR genes in this pathway
DELLA_RESPONSE_TO_TSA_AND_BUTYRATE 2117All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_24HR 4330All SZGR genes in this pathway
LY_AGING_OLD_DN 5635All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C7 6844All SZGR genes in this pathway
SIMBULAN_PARP1_TARGETS_DN 1710All SZGR genes in this pathway
LY_AGING_MIDDLE_DN 1610All SZGR genes in this pathway
HU_GENOTOXIC_DAMAGE_4HR 3528All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P6 9144All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP 317208All SZGR genes in this pathway
WONG_PROTEASOME_GENE_MODULE 4935All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_A_DN 187All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
KUMAMOTO_RESPONSE_TO_NUTLIN_3A_DN 105All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_UP 250168All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_UP 12568All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
FRASOR_RESPONSE_TO_SERM_OR_FULVESTRANT_DN 5029All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_DN 240153All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP 163102All SZGR genes in this pathway
HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_DN 5033All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
ZHAN_EARLY_DIFFERENTIATION_GENES_DN 4229All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
CROONQUIST_IL6_DEPRIVATION_DN 9869All SZGR genes in this pathway
CROONQUIST_NRAS_SIGNALING_DN 7247All SZGR genes in this pathway
CROONQUIST_NRAS_VS_STROMAL_STIMULATION_DN 9965All SZGR genes in this pathway
ISHIDA_E2F_TARGETS 5327All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_UP 288168All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP 178108All SZGR genes in this pathway
PUJANA_BREAST_CANCER_WITH_BRCA1_MUTATED_UP 5627All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_24HR_DN 251151All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1 237159All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN 225124All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA2_UP 8750All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_LITERATURE 4425All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G2_M 216124All SZGR genes in this pathway
CHICAS_RB1_TARGETS_GROWING 243155All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_UP 13596All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
LE_NEURONAL_DIFFERENTIATION_DN 1916All SZGR genes in this pathway
FOSTER_KDM1A_TARGETS_DN 211119All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP 289184All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_DN 11469All SZGR genes in this pathway
ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_24HR 12873All SZGR genes in this pathway


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.