Found 484 literature records

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Entrez ID	Description
1029	Results define a mechanism by which the ARF tumor suppressor targets the translational repression of specific oncogenes during neoplastic transformation.
22943	Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma.
672	This feature item briefly reviews the relation of the tumor suppressor function of BRCA1 with DNA damage and repair.
84417	Overexpression of candidate tumor suppressor ECRG4 inhibits glioma proliferation and invasion.
9940	"DLEC1 is often down-regulated by CpG methylation and shows tumor inhibitory function in renal cell carcinoma cells, indicating its role as a tumor suppressor"
5333	"PLCD1 is silenced by promoter methylation in breast cancer. Silencing of PLCD1 is reversed by demethylation which leads to the disruption of cell cycle at G2/M phase in breast cancer, indicating that PLCD1 functions as a tumor suppressor in this tumor."
23635	results indicate that cigarette smoking is a cause of SSBP2 promoter methylation and that SSBP2 harbors a tumor suppressive role in ESCC through inhibition of the Wnt signaling pathway
406999	frequently downregulated miR-217 can regulate KRAS and function as a tumor suppressor in pancreatic ductal adenocarcinoma (PDAC).
84911	ZNF382 is a functional tumor suppressor frequently methylated in multiple carcinomas.
9314	Expression of the tumor suppressor Kr??ppel-like factor 4 as a prognostic predictor for colon cancer.
3248	Results demonstrate that 15-PGDH acts as a tumor suppressor in gastric cancer and provide further validation for 15-PGDH as a potential therapeutic target for gastric cancer.
6910	a novel functional tumor suppressor gene TBX5 inactivated by promoter methylation in colon cancer was identified. Detection of methylated TBX5 may serve as a potential biomarker for the prognosis of this malignancy.
10048	Findings reveal that RanBPM plays a novel role in regulating Mgl-1 stability and contributes to its biological function as a tumor suppressor.
9148	NEURL1 expression was downregulated in medulloblastoma compared to normal cerebellar tissue with lowest expression levels in hedgehog-activated tumors; conclude NEURL1 is candidate tumor suppressor in MB at least in part through effects on Notch pathway
324	Loss of the APC tumor suppressor gene causes upregulation of a DNA demethylase system; tissues taken from human subjects showed the demethylation of these same key developmental genes in human colon adenomas.
8772	"our data demonstrate that in response to taxol, Plk1 endows death-promoting and tumor-suppressor functions to its substrate, FADD"
9770	Results suggest that RASSF2 encodes a novel epigenetically inactivated candidate tumor suppressor gene in thyroid carcinogenesis.
23513	"hScrib, a human homolog of Drosophila neoplastic tumor suppressor, is involved in the progress of endometrial cancer."
644943	This is the first report demonstrating that RASSF10 can act as a tumor suppressor gene and is frequently methylated in gliomas
5795	Germline epigenetic silencing of the tumor suppressor gene PTPRJ in early-onset familial colorectal cancer.
84651	ECRG2 is a novel member of the Kazal-type serine protease inhibitor family and may function as a tumor suppressor gene regulating the protease cascades during carcinogenesis and invasion of esophageal cancer.
7980	TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma.
10395	The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation.
406884	study identifies let-7b as a tumor suppressor that represses cancer cell proliferation and migration as well as tumor metastasis in mouse melanoma cells.
10253	"Spry2 expression is downregulated and miRNA-21 is upregulated in the clinical samples of colon cancer, which correlates with clinical stage of disease. Thus, Spry2 functions as a tumor suppressor in colon cancer."
1958	"Data show that miR-183 has a potential oncogenic role through the regulation of 2 tumor suppressor genes, EGR1 and PTEN, and the deregulation of this fundamental miRNA regulatory network may be central to many tumor types."
5728	"Data show that miR-183 has a potential oncogenic role through the regulation of 2 tumor suppressor genes, EGR1 and PTEN, and the deregulation of this fundamental miRNA regulatory network may be central to many tumor types."
5728	Clinical significance of tumor suppressor PTEN in colorectal carcinoma.
10395	A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors.
26468	hLHX6.1 could be a new tumor suppressor gene in the cervix.
4089	Results define a molecular mechanism that explains how loss of the tumor suppressor Smad4 promotes colorectal cancer progression
51741	Bmi1 regulates cell fate via tumor suppressor WWOX repression in small-cell lung cancer cells.
5079	tumor suppressor gene PAX5 is inactivated by promoter methylation in liver cancer. PAX5 contributes to suppression of hepatocarcinogenesis by inhibiting cell proliferation and inducing cell apoptosis through direct regulating p53 signaling pathway.
7545	"ZIC1 is downregulated through promoter hypermethylation, and functions as a tumor suppressor gene in colorectal cancer."
6405	Endogenous SEMA3F acts as a suppressor of the growth and metastasis of human colorectal cancer cells.
574411	MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14).
6934	T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis.
23261	Findings define properties of CAMTA1 in growth suppression and neuronal differentiation that support its assignment as a 1p36 tumor suppressor gene in neuroblastoma.
1848	Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype.
23671	the tumor suppressor activity of TMEFF2 requires the cytoplasmic/transmembrane portion of the protein and correlates with its ability to bind to SARDH and to modulate the level of sarcosine.
56925	Latexin expression is downregulated in human gastric carcinomas and exhibits tumor suppressor potential.
1500	Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene.
6416	These results indicated that MKK4 acts as a tumor suppressor and may represent an important therapeutic target for the treatment of ovarian cancer
2041	"The present study reveals a novel function for EphA1 and EphB2 in the induction of autophagy, suggesting a tumor suppressor role for these proteins in colorectal cancer."
2048	"The present study reveals a novel function for EphA1 and EphB2 in the induction of autophagy, suggesting a tumor suppressor role for these proteins in colorectal cancer."
11122	"[review] High-throughput mutational analysis identifies loss-of-function mutations in six PTPs in human colon cancers, providing critical cancer genetics evidence that PTPs can act as tumour suppressor genes."
9365	our results suggest that klotho is inactivated through promoter hypermethylation and potentially functions as a tumor suppressor gene in colorectal cancer
5048	these results suggest that LIS1 plays a potential tumor suppressor role in the development and progression of hepatocellular carcinoma.
9365	KL1 internal repeat mediates klotho tumor suppressor activities and inhibits bFGF and IGF-I signaling in pancreatic cancer.
84260	MITOSTATIN may acts as a tumor suppressor gene in prostate cancer.

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