Found 616 literature records

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Entrez ID	Description
23095	"KIF1Bbeta may act as a haploinsufficient tumor suppressor, and its allelic loss may be involved in the pathogenesis of neuroblastoma and other cancers."
51741	The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX.
7345	Epigenetic inactivation of UCHL1 is common in primary hepatocellular carcinomas(HCCs) and other digestive tumors and appears to be functional tumor suppressor involved in tumorigenesis of HCCs and other digestive cancers.
1029	COOH-terminal binding protein regulates expression of the p16INK4A tumor suppressor and senescence in primary human cells.
5727	Heterozygous mutations in the tumor suppressor gene PATCHED provoke basal cell carcinoma-like features in human organotypic skin cultures.
11178	Down-regulation of tumor suppressor gene FEZ1/LZTS1 in breast carcinoma involves promoter methylation and associates with metastasis.
4057	Lactotransferrin is likely to be a candidate tumor suppressor and downregulates the development of nasopharyngeal carcinoma (NPC) by inhibiting NPC proliferation through induction of cell cycle arrest and modulation of the MAPK signaling pathway.
57447	"NDRG2 as a candidate tumor suppressor gene that is epigenetically silenced in the majority of primary glioblastomas, but not in lower grade astrocytomas and secondary glioblastomas."
6598	Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability.
4978	"OPCML is a broad tumor suppressor, which is frequently inactivated by methylation in multiple malignancies."
407040	miR-34a represents a tumor suppressor gene which is inactivated by CpG methylation and subsequent transcriptional silencing in a broad range of tumors.
23705	TSLC1 acts as a candidate tumor suppressor gene for neuroblastoma.
7157	data link EWS-FLI1 to the NOTCH and p53 pathways and provide a plausible basis both for NOTCH tumor suppressor effects and oncogenesis of cancers that retain wild-type p53
116135	suggest that LRRC3B is a putative tumor suppressor gene that is silenced in gastric cancers by epigenetic mechanisms and that LRRC3B silencing in cancer may play an important role in tumor escape from immune surveillance
7704	Increased expression of the tumor suppressor PLZF in malignant melanomas is associated with long-term patient survival.
116135	LRRC3B may be a novel methylation-sensitive tumor suppressor gene in CRC. LRRC3B methylation has significant tumor specificity and may be a biomarker of CRC.
1029	"Data demonstrate that Bmi1 promotes prostate tumorigenesis, and that Bmi1 expression is associated with a reduction in tumor suppressors p16(INK4A) and p14(ARF)."
83595	Sox7 is a tumor suppressor that functions as an independent checkpoint for beta-catenin transcriptional activity. Inactivation of Sox7 could promote the development of a majority of colorectal tumors and approximately half of prostate tumors.
27122	Aberrant methylation of the DKK3 promoter downregulates mRNA & protein expression in human breast cancer development. It may be a tumor suppressor in normal breast tissue.
378805	Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2.
84260	"MITOSTATIN was found within a 3.2-kb transcript for an approximately 62 kDa mitochondrial protein with tumor suppressor activity. It inhibits cell growth, is proapoptotic and downregulates Hsp27."
7040	Tumor suppressor and oncogene actions of TGFbeta1 occur early in skin carcinogenesis and are mediated by Smad3.
4771	"The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP."
26038	study demonstrated the existence of somatic mutations and methylation of CHD5 in primary epithelial ovarian cancers; CHD5 may play a role as a tumor suppressor gene in ovarian cancer
94241	"Roles for microRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1."
2619	"Gas1 has all the expected properties of a melanoma tumor suppressor: suppression of metastasis in a spontaneous metastasis assay, promotion of apoptosis following dissemination of cells to secondary sites, and down-regulation in human melanoma metastasis."
10395	"The results suggest that DLC1 may function as a tumor suppressor gene in meningiomas. Furthermore, DLC1 promoter methylation does not appear to be responsible for the decreased DLC1 expression in these tumors."
6423	"SFRP2 gene is a high-frequent target of epigenetic inactivation in human breast cancer; its methylation leads to abrogation of SFRP2 expression, conferring a growth advantage to epithelial mammary cells; this supports a tumor suppressive function of SFRP2"
65268	Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific.
3487	conclusion: decreased IGFBP-4 tumor expression might be a step in the progression from primary to metastatic melanoma; data lend support to a recently-described novel tumor suppressor role of secreting IGFBPs in melanoma
2587	GALR1 is a tumor suppressor gene in head and neck squamous cell carcinoma
10653	data support the role of SPINT2 as a putative tumor suppressor gene in medulloblastoma and further implicate dysregulation of the HGF/MET signaling pathway in the pathogenesis of medulloblastoma
79633	Fat4 may be a breast tumor suppressor gene
51684	human tumor suppressor SUFU has a role in Hedgehog signaling [review]
57863	finding suggests that NECL1 may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation
57863	suggests that NECL1 may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation
406967	Results showing a role for miR-192/215 in cell proliferation combined with recent observations that these miRNAs are underexpressed in primary cancers support the idea that miR-192 and miR-215 function as tumor suppressors.
406997	Results showing a role for miR-192/215 in cell proliferation combined with recent observations that these miRNAs are underexpressed in primary cancers support the idea that miR-192 and miR-215 function as tumor suppressors.
406913	Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells.
2195	Frequent loss of heterozygosity and altered expression of the candidate tumor suppressor gene 'FAT' in human astrocytic tumors.
7545	These results revealed ZIC1 as a novel candidate tumor suppressor gene downregulated through promoter hypermethylation in gastric cancer.
11184	Restoring wild-type HPK1 protein in pancreatic cancer cells led to the increase in p21 and p27 protein expression and cell cycle arrest. HPK1 may function as a novel tumor suppressor and its loss plays a critical role in pancreatic cancer.
1031	Cdk4 inhibitor p18(Ink4c) is a tumor suppressor in cyclin D1-driven PNET.
1029	The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a.
5925	The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a.
54845	"Results demonstrate that RBM35A functions as a tumor suppressor in colon cancer cells, and suggest that RBM35A is involved in posttranscriptional regulation of a number of genes by exerting a differential effect on protein translation via 5'UTRs of mRNAs."
2131	"The tumor suppressor gene EXT1 is involved in the formation of multiple osteochondromas, which can progress to become secondary peripheral chondrosarcomas."
2132	"The tumor suppressor gene EXT2 is involved in the formation of multiple osteochondromas, which can progress to become secondary peripheral chondrosarcomas."
639	Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies.
6850	Spleen tyrosine kinase as a novel candidate tumor suppressor gene for human oral squamous cell carcinoma.

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