Found 53 literature records

Page :1 2

Entrez ID	Description
11108	"PFM1 (PRDM4), a new member of the PR-domain family, maps to a tumor suppressor locus on human chromosome 12q23-q24.1. These results suggest a role for PFM1 in cell differentiation and tumor suppression, remarkably consistent with the known functions of the PR-domain family."
4089	Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.
23705	TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer.
7428	Review. The von Hippel-Lindau tumor suppressor protein regulates hypoxia-inducible gene transcription. It is a subunit of an E3 ubiquitin ligase targeting HIFalpha subunits.
5268	"Maspin, a breast tumor suppressor gene is a valuable marker of the disease progression in breast neoplasms."
6648	MnSOD may be a tumor suppressor gene in human pancreatic cancer
6648	MnSOD may be a tumor suppressor gene in pancreatic cancer
1029	"Expression and characterization of Syrian golden hamster p16, a homologue of human tumor suppressor p16 INK4A."
1848	Results show that DUSP6 exerts apparent tumor-suppressive effects in vitro and suggest that DUSP6 is a strong candidate tumor suppressor gene at 12q22 locus.
2272	"exogenous expression of FHIT in Panc-1 cells affects genes regulating cell cycle arrest and apoptosis, and these molecular changes may contribute to the tumor suppressor activity of the FHIT gene"
51741	The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis.
5795	"A candidate tumor suppressor gene because its expression was blocked in rat and human thyroid transformed cells, and its restoration reverted their neoplastic phenotype."
7428	"in pancreatic cancer cells, the p38-mediated phosphorylation of HIF-1alpha contributed to the inhibition of HIF-1alpha and von Hippel-Lindau tumor suppressor protein interaction during ischemia"
5909	data identify rap1GAP as a putative tumor suppressor gene in pancreatic cancer
6282	"Expression of S100A11, a putative tumor suppressor gene, is increased in the early stage of pancreatic carcinogenesis and decreased during subsequent progression to cancer."
1029	Physical and functional interaction of the p14ARF tumor suppressor with ribosomes.
4015	BCL2 repression by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells
5728	transcriptional down-regulation of the tumor suppressor PTEN in pancreatic adenocarcinoma if facilitated by effect of K-RAS/ERK on TGFbeta
1029	combined with screening of K-ras mutations and allelic losses of tumor suppressors p16 and DPC4 represents a very sensitive approach in screening for pancreatic malignancy.
4089	combined with screening of K-ras mutations and allelic losses of tumor suppressors p16 and DPC4 represents a very sensitive approach in screening for pancreatic malignancy.
3175	"ONECUT1 expression is lost in pancreatic cancer cells, suggesting a tumor suppressor function in this malignancy."
160728	SLC5A8 may function as a tumor suppressor gene whose silencing may contribute to carcinogenesis and progression of pancreatic cancer.
1050	"aberrant silencing, as well as, inappropriate cytoplasmic localization of C/EBPalpha causes dysregulation of its function, suggesting that C/EBPalpha is a novel candidate tumor suppressor gene in pancreatic cancer cells"
11184	Restoring wild-type HPK1 protein in pancreatic cancer cells led to the increase in p21 and p27 protein expression and cell cycle arrest. HPK1 may function as a novel tumor suppressor and its loss plays a critical role in pancreatic cancer.
9077	Expression of the tumor suppressor ARHI inhibits the growth of pancreatic cancer cells by inducing G1 cell cycle arrest.
5728	Data show that Protein levels of tumor suppressor targets of the miRNAs were increased by antisense to miR-21 (PTEN and RECK) and miR-221 (p27).
7057	The upregulation of both sst2 and TSP-1 tumor suppressors may function as an early negative feedback to restrain pancreatic carcinogenesis.
56999	"The ADAMTS9 gene (ADAM metallopeptidase with thrombospondin type 1 motif, 9); has been characterized as a novel tumor suppressor gene in and epigenetically silenced in association with lymph node metastases in nasopharyngeal carcinoma."
406938	miR-146a suppresses invasion of pancreatic cancer cells.
4851	"Loss of Notch1 in this model resulted in increased tumor incidence and progression, implying that Notch1 can function as a tumor suppressor gene in PDAC."
6711	"reduced SPTBN1 expression correlated with shorter survival of pancreatic cancer patients, suggesting a tumor suppressor function of this gene"
8125	Data provide evidence that the tumor suppressor function of pp32 can be attributed to its ability to disrupt HuR binding to target mRNAs encoding key proteins for cancer cell survival and drug efficacy.
10397	NDRG1 completely inhibits growth in anchorage-independent assays and in vivo supports a biological function as a tumor suppressor in pancreatic cancer.
51100	The expression of Bif-1 is downregulated in a subset of pancreatic ductal adenocarcinoma. This novel finding is in agreement with the tumor suppressor function of Bif-1.
675	Context dependence of checkpoint kinase 1 as a therapeutic target for pancreatic cancers deficient in the BRCA2 tumor suppressor.
7157	Context dependence of checkpoint kinase 1 as a therapeutic target for pancreatic cancers deficient in the BRCA2 tumor suppressor.
5925	miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor.
9046	Mutational analysis of DOK2 tumor suppressor gene in acute leukemias.
94241	This novel TP53INP1 activity on the regulation of SPARC expression could explain in part its tumor suppressor function in pancreatic adenocarcinoma by modulating cellular spreading during the metastatic process
5909	The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma.
9365	KL1 internal repeat mediates klotho tumor suppressor activities and inhibits bFGF and IGF-I signaling in pancreatic cancer.
406942	findings establish miR-150 as a novel regulator of MUC4 and a tumor suppressor miRNA in pancreatic cancer
1029	Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells.
8665	findings established a new mechanism of rRNA decay regulation mediated by hnRNP K/eIF3f and suggest that the tumor suppressive function of eIF3f may link to impaired rRNA degradation and translation
26471	"NUPR1 negatively regulates autophagy-mediated cell death via AURKA, in line with the idea of a tumor suppressor role of autophagy in cancer."
6665	Results indicate that the expression of SOX15 in pancreatic cancer cell lines with undetectable expression resulted in reduced viability of cancer cells both in vitro and in vivo demonstrating its tumor suppressive capability.
5579	established an important role for PKCbeta1 in PANC1 cells suggesting it would act as a suppressor of tumorigenic behavior in pancreatic cancer
1788	provide evidence that Dnmt3a and Dnmt3b function as tumor suppressor genes in the prevention of lymphoid malignancies in mice.
1528	Results define CYB5A as a novel prognostic factor for PDAC that exerts its tumor-suppressor function through autophagy induction and TRAF6 modulation.
6387	"These data demonstrate a functional tumor suppressive role for the normal expression of CXCL12 in pancreatic ducts, regulating both tumor growth andcellulardissemination to metastatic sites."

---