Gene: ARL15

54622
ARFRP2
ADP ribosylation factor like GTPase 15
protein-coding
5q11.2
Ensembl:ENSG00000185305 Vega:OTTHUMG00000162287 UniprotKB:Q9NXU5
NC_000005.10
PubMed|SNP Mapped
23   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.742e-1 (AD)  8.611e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs200457189chr5:54269225-54269251 (GRCh38.p7)delT(A)4alcohol dependenceIndel(Insertion and Deletion)
rs35951chr5:54296531 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs35952chr5:54296333 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7704911chr5:54291872 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6450184chr5:54286675 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs7725454chr5:54286570 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3776641chr5:54286422 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3776642chr5:54286396 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs10940373chr5:54279861 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs41151chr5:54269224 (GRCh38.p7)G>A / G>C / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs388337chr5:54261708 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3857282chr5:54248075 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6872430chr5:54245925 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs6872062chr5:54245723 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs166093chr5:54245095 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs3797237chr5:54241912 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs250378chr5:54241769 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2407405chr5:54241716 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10044346chr5:54241324 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs9292042chr5:54241168 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs12233919chr5:54239714 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs3910951chr5:54239417 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs33282chr5:54235475 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EXOC60.874
SLC1A10.869
BMPR20.869
SHOC20.866
MEF2A0.863
GPD1L0.857
UBE2K0.856
SKAP20.856
VPS360.854
SEC23A0.853

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.462
LRAT-0.44
OR4F5-0.438
OR4F29-0.417
GPR143-0.411
NKX2-2-0.41
AQP5-0.407
EYA2-0.402
DPF3-0.399
C22orf31-0.389

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ARL15 mRNA"25614096
D000082AcetaminophenAcetaminophen results in increased expression of ARL15 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of ARL15 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of ARL15 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ARL15 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ARL15 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of ARL15 mRNA21757418
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARL15 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARL15 mRNA19770486|2071347
C006780bisphenol Abisphenol A results in decreased expression of ARL15 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of ARL15 mRNA25181051
D002737ChloropreneChloroprene results in decreased expression of ARL15 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of ARL15 mRNA24386269
D003471CuprizoneCuprizone results in decreased expression of ARL15 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of ARL15 mRNA20106945|2798913
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ARL15 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of ARL15 mRNA28302478
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARL15 mRNA22079256
D005421Flavoring Agents[Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of ARL15 mRNA28065790
D005990Glycerol[Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of ARL15 mRNA28065790
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ARL15 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of ARL15 mRNA27392435
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ARL15 mRNA"26251327
D009151Mustard GasMustard Gas affects the expression of ARL15 mRNA15651846
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ARL15 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ARL15 mRNA"25620056
D009538Nicotine[Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of ARL15 mRNA28065790
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ARL15 mRNA25729387
D010416PentachlorophenolPentachlorophenol results in increased expression of ARL15 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of ARL15 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of ARL15 mRNA20813756
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARL15 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ARL15 mRNA22079256|2271453
D019946Propylene Glycol[Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of ARL15 mRNA28065790
D011441PropylthiouracilPropylthiouracil results in increased expression of ARL15 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of ARL15 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ARL15 mRNA25895662
D013629TamoxifenTamoxifen results in increased expression of ARL15 mRNA25123088
D013853ThioacetamideThioacetamide results in decreased expression of ARL15 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of ARL15 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ARL15 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of ARL15 mRNA25729387
D014520UrethaneUrethane results in increased expression of ARL15 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of ARL15 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ARL15 mRNA23179753|2800136
D014635Valproic AcidValproic Acid affects the expression of ARL15 mRNA17963808
D014638VanadatesVanadates results in increased expression of ARL15 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ARL15 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005525GTP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24962325Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. (2014 Sep 1)Kapoor MDrug Alcohol Depend