DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 1897:1904

E3 ligase: FBXW7

DEGRON score: 0.9969

ASA_SCORE: 80

COIL: 0.904

CONS_SCORE: -1000

DSS_SCORE: 0.5435

HELIX: 0.0166

FCONS_SCORE: 2.0008

RIG_SCORE: 0.6546

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1896M	TCGA-12-3651	GBM	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.T1896M	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.T1896M	ACH-000717	Esophageal Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.T1896M	COLO-680N	oesophagus	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.T1908A	TCGA-85-6560	LUSC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.P1897S	TCGA-AJ-A23O	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.6752
p.P1901L	TCGA-AX-A060	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.T1894M	TCGA-B5-A11H	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.P1910T	TCGA-BR-4362	STAD	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.T1903M	TCGA-BS-A0TG	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.6312
p.T1903M	SIDM00672	Hepatocellular Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.6312
p.T1903M	SIDM00697	Small Cell Lung Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.6312
p.A1895T	TCGA-CV-7568	HNSC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.I1906M	TCGA-EE-A2GN	SKCM	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.A1914V	TCGA-F5-6813	READ	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.W1905C	TCGA-GD-A3OP	BLCA	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.T1911S	TCGA-W5-AA39	CHOL	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.5833
p.W1908C	DO761	BLCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.T1906M	DO227976	COCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.T1906M	DO233855	GACA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.T1906M	DO42209	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.T1899M	DO13845	GBM	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7423
p.A1898T	DO14160	HNSC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7139
p.S1896Y	DO15238	HNSC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.T1911A	DO26752	LUSC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.5833
p.I1909M	DO37896	SKCM	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.P1913T	DO38336	STAD	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.5278
p.P1900S	DO43290	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.6752
p.P1904L	DO42576	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.T1897M	DO42825	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7423
p.P1910L	SIDM01210	Glioblastoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.P1910L	ACH-002259	Brain Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.P1910L	KNS-81-FD	central_nervous_system	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.W1905R	SIDM01635	Glioblastoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.W1905R	ACH-000027	Brain Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.T1900A	ACH-000940	Endometrial/Uterine Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.7139
p.T1900A	AN3-CA	endometrium	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSTPGTT

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of PSSTPGTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	1897:1904	PSSTPGTT	FBXW7	0.9969	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2149:2156	PSSTPGTT	FBXW7	0.6671	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2426:2433	PSSTPGTT	FBXW7	0.9861	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2455:2462	PSSTPGTT	FBXW7	0.9933	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2706:2713	PSSTPGTT	FBXW7	0.7565	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2983:2990	PSSTPGTT	FBXW7	0.9197	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3406:3413	PSSTPGTT	FBXW7	0.7565	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3683:3690	PSSTPGTT	FBXW7	0.9796	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3712:3719	PSSTPGTT	FBXW7	0.9972	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3963:3970	PSSTPGTT	FBXW7	0.9055	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4240:4247	PSSTPGTT	FBXW7	0.9361	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4382:4389	PSSTPGTT	FBXW7	0.9969	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4440:4447	PSSTPGTT	FBXW7	0.9266	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4696:4703	PSSTPGTT	FBXW7	0.685	More...