DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 2149:2156

E3 ligase: FBXW7

DEGRON score: 0.6671

ASA_SCORE: 89.175

COIL: 0.9636

CONS_SCORE: 0.3177

DSS_SCORE: 0.6903

HELIX: 0.0105

FCONS_SCORE: 0.9455

RIG_SCORE: 0.5937

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2141M	TCGA-AJ-A3BH	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.P2157H	TCGA-D1-A17H	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.T2139M	DO43186	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.T2144M	DO41638	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.P2160H	DO41847	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.A2166T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.A2166T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.A2166T	ACH-000910	Breast Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.I2140F	SIDM01173	Rhabdomyosarcoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons