DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 4240:4247

E3 ligase: FBXW7

DEGRON score: 0.9361

ASA_SCORE: 75.85

COIL: 0.8263

CONS_SCORE: 0.3299

DSS_SCORE: 0.5356

HELIX: 0.0256

FCONS_SCORE: 1.0063

RIG_SCORE: 0.6884

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P4244L	TCGA-AA-3492	COAD	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.P4244L	SIDM01043	Other Sarcomas	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.T4254I	TCGA-AJ-A3EK	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.1389
p.A4257T	TCGA-AJ-A5DW	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.A4257S	TCGA-B5-A1MR	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.M4239T	TCGA-F4-6856	COAD	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.M4239T	22RV1	prostate	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.M4239T	SNU-175	large_intestine	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.G4245E	TCGA-W3-A828	SKCM	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.6087
p.I4252T	DO222427	BTCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.M4242T	DO9114	COAD	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7423
p.P4247L	DO8224	COAD	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.T4249M	DO50442	ESAD	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.G4248E	DO51273	SKCM	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.T4257I	DO41584	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.E4252K	SIDM00216	Colorectal Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.E4252K	SIDM00256	Neuroblastoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.E4252K	SIDM01577	Plasma Cell Myeloma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.E4252K	ACH-000989	Colon/Colorectal Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.E4252K	SNU-175	large_intestine	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.T4246M	SIDM00672	Hepatocellular Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.6312
p.T4246M	SIDM01210	Glioblastoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.6312
p.T4246M	KNS-81-FD	central_nervous_system	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.6312
p.T4246M	Hep_3B2_1-7	NS	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.6312
p.T4237K	SIDM00652	Small Cell Lung Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.T4237K	ACH-000780	Lung Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.T4237K	NCI-H1105	lung	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.L4253M	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.L4253M	ACH-001233	Lung Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.L4253M	VMRC-LCD	lung	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.T4237M	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.T4237M	ACH-001738	Leukemia	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.T4237M	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.S4242C	SIDM00560	Gastric Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.643
p.S4242C	ACH-000678	Gastric Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.643
p.S4242C	MKN7	stomach	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.643

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSTPGTT

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of PSSTPGTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	1897:1904	PSSTPGTT	FBXW7	0.9969	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2149:2156	PSSTPGTT	FBXW7	0.6671	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2426:2433	PSSTPGTT	FBXW7	0.9861	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2455:2462	PSSTPGTT	FBXW7	0.9933	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2706:2713	PSSTPGTT	FBXW7	0.7565	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2983:2990	PSSTPGTT	FBXW7	0.9197	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3406:3413	PSSTPGTT	FBXW7	0.7565	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3683:3690	PSSTPGTT	FBXW7	0.9796	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3712:3719	PSSTPGTT	FBXW7	0.9972	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3963:3970	PSSTPGTT	FBXW7	0.9055	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4240:4247	PSSTPGTT	FBXW7	0.9361	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4382:4389	PSSTPGTT	FBXW7	0.9969	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4440:4447	PSSTPGTT	FBXW7	0.9266	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4696:4703	PSSTPGTT	FBXW7	0.685	More...