DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 4382:4389

E3 ligase: FBXW7

DEGRON score: 0.9969

ASA_SCORE: 80.575

COIL: 0.9056

CONS_SCORE: 0.3824

DSS_SCORE: 0.6031

HELIX: 0.019

FCONS_SCORE: 1.1966

RIG_SCORE: 0.6731

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T4388M	TCGA-BB-4223	HNSC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.6312
p.T4388M	TCGA-CR-7373	HNSC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.6312
p.S4383Y	TCGA-D3-A1Q1	SKCM	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.6009
p.P4386S	TCGA-DA-A1I8	SKCM	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.6752
p.S4383F	TCGA-EK-A3GK	CESC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.6871
p.L4392F	TCGA-XE-A8H5	TGCT	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.S4384C	TCGA-ZF-AA4R	BLCA	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.643
p.S4387C	DO219083	BLCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7541
p.T4391M	DO225198	BRCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.T4391M	DO16093	HNSC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.T4391M	DO15607	HNSC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.S4386F	DO49964	CESC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7982
p.P4389S	DO37424	SKCM	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.6752
p.S4386Y	DO37445	SKCM	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.712
p.T4382P	DO38527	STAD	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7031
p.S4380R	DO41758	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.T4372S	SIDM00917	Acute Myeloid Leukemia	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.T4372S	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.T4389A	ACH-002231	Brain Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.7139
p.T4389A	D-566MG	central_nervous_system	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.7139
p.T4385P	NB13	autonomic_ganglia	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons