DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 3712:3719

E3 ligase: FBXW7

DEGRON score: 0.9972

ASA_SCORE: 83.1

COIL: 0.9299

CONS_SCORE: 0.3073

DSS_SCORE: 0.647

HELIX: 0.0191

FCONS_SCORE: 1.1049

RIG_SCORE: 0.6823

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3712Q	TCGA-05-4390	LUAD	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.7035
p.P3712A	TCGA-49-6767	LUAD	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.7503
p.T3728I	TCGA-96-8170	LUSC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.0833
p.S3726I	TCGA-A5-A0G2	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.1389
p.T3703I	TCGA-EB-A5SE	SKCM	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.0833
p.G3707E	TCGA-EE-A3AE	SKCM	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.P3712L	TCGA-FI-A2EU	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.6471
p.E3707A	DO224957	BRCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.T3714I	DO44802	LICA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7078
p.P3715A	DO23586	LUAD	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7503
p.P3715Q	DO23562	LUAD	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7035
p.A3713T	DO220891	MELA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7139
p.T3704S	DO36447	READ	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.A3703T	DO37896	SKCM	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.0833
p.A3703T	DO37951	SKCM	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.0833
p.T3706I	DO47295	SKCM	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.G3710E	DO37802	SKCM	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.P3715L	DO229218	THCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.P3715L	DO229224	THCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.P3715L	DO42865	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.S3711P	DO229213	THCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.S3729I	DO41235	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.A3710T	SIDM00238	Ovarian Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.A3710T	SIDM00081	Melanoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.A3710T	SIDM00247	Gastric Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.A3710T	SIDM01471	Chronic Myelogenous Leukemia	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.A3710T	ACH-000356	Gastric Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.A3710T	ACH-000947	Ovarian Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.A3710T	MKN45	stomach	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.A3710T	OVK-18	ovary	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.A3710T	SK-MEL-28	skin	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.E3724K	SIDM01159	Other Sarcomas	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.E3724K	SW872	soft_tissue	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.E3704A	ACH-000989	Colon/Colorectal Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.E3704A	SNU-175	large_intestine	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSTPGTT

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of PSSTPGTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	1897:1904	PSSTPGTT	FBXW7	0.9969	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2149:2156	PSSTPGTT	FBXW7	0.6671	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2426:2433	PSSTPGTT	FBXW7	0.9861	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2455:2462	PSSTPGTT	FBXW7	0.9933	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2706:2713	PSSTPGTT	FBXW7	0.7565	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2983:2990	PSSTPGTT	FBXW7	0.9197	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3406:3413	PSSTPGTT	FBXW7	0.7565	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3683:3690	PSSTPGTT	FBXW7	0.9796	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3712:3719	PSSTPGTT	FBXW7	0.9972	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3963:3970	PSSTPGTT	FBXW7	0.9055	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4240:4247	PSSTPGTT	FBXW7	0.9361	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4382:4389	PSSTPGTT	FBXW7	0.9969	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4440:4447	PSSTPGTT	FBXW7	0.9266	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4696:4703	PSSTPGTT	FBXW7	0.685	More...