DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 4696:4703

E3 ligase: FBXW7

DEGRON score: 0.685

ASA_SCORE: 91.125

COIL: 0.9596

CONS_SCORE: 0.2838

DSS_SCORE: 0.6658

HELIX: 0.008

FCONS_SCORE: 1.0245

RIG_SCORE: 0.6082

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P4700L	TCGA-EW-A1PB	BRCA	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.P4703L	DO4695	BRCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.S4701L	DO229244	LMS	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7667
p.T4694I	SIDM00216	Colorectal Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.T4694I	ACH-000989	Colon/Colorectal Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.T4690N	SIDM00957	Colorectal Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.T4688A	SIDM00845	Burkitt's Lymphoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.T4688A	SIDM00846	Cervical Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.T4688A	SIDM00257	Neuroblastoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.T4688A	SIDM00720	Mesothelioma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.T4688A	SIDM00760	Small Cell Lung Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.T4688A	SIDM01387	Small Cell Lung Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.T4688A	SIDM01525	Acute Myeloid Leukemia	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons