DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 4440:4447

E3 ligase: FBXW7

DEGRON score: 0.9266

ASA_SCORE: 86.6625

COIL: 0.9163

CONS_SCORE: 0.2557

DSS_SCORE: 0.6297

HELIX: 0.0168

FCONS_SCORE: 0.9375

RIG_SCORE: 0.6846

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T4434I	TCGA-4X-A9FD	THYM	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.A4432V	TCGA-AX-A05Z	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.A4432V	TCGA-UY-A8OD	BLCA	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.S4433P	TCGA-YF-AA3M	BLCA	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.1389
p.S4436P	DO51952	BLCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.A4435V	DO219039	BLCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.A4435V	DO40884	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.P4443L	DO222826	COCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.P4443L	DO229010	COCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.P4443L	DO229013	COCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.P4443L	DO229016	COCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.P4443L	DO229003	COCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.P4443L	DO229005	COCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.P4443L	DO46969	RECA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.A4431T	DO19208	KIRC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.0833
p.A4431T	DO38711	STAD	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.0833
p.G4448R	DO23490	LINC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.T4455S	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.L4450V	SIDM00463	T-Lymphoblastic Leukemia	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.L4450V	ACH-000372	Leukemia	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.L4450V	P12-ICHIKAWA	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.S4436C	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.S4436C	ACH-000893	Lung Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.S4436C	NCI-H1651	lung	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.T4437M	SIDM00214	Colorectal Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.T4437M	SNU-407	large_intestine	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.A4432T	SIDM00247	Gastric Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.A4432T	ACH-000356	Gastric Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.A4432T	MKN45	stomach	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSTPGTT

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of PSSTPGTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	1897:1904	PSSTPGTT	FBXW7	0.9969	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2149:2156	PSSTPGTT	FBXW7	0.6671	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2426:2433	PSSTPGTT	FBXW7	0.9861	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2455:2462	PSSTPGTT	FBXW7	0.9933	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2706:2713	PSSTPGTT	FBXW7	0.7565	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2983:2990	PSSTPGTT	FBXW7	0.9197	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3406:3413	PSSTPGTT	FBXW7	0.7565	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3683:3690	PSSTPGTT	FBXW7	0.9796	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3712:3719	PSSTPGTT	FBXW7	0.9972	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3963:3970	PSSTPGTT	FBXW7	0.9055	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4240:4247	PSSTPGTT	FBXW7	0.9361	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4382:4389	PSSTPGTT	FBXW7	0.9969	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4440:4447	PSSTPGTT	FBXW7	0.9266	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4696:4703	PSSTPGTT	FBXW7	0.685	More...