DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 2426:2433

E3 ligase: FBXW7

DEGRON score: 0.9861

ASA_SCORE: 80.0125

COIL: 0.8981

CONS_SCORE: -624.9419

DSS_SCORE: 0.542

HELIX: 0.0214

FCONS_SCORE: 1.9656

RIG_SCORE: 0.6834

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2428C	TCGA-58-A46K	LUSC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.643
p.P2430L	TCGA-DU-6392	LGG	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.P2433L	DO22237	LGG	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.S2431C	DO45432	LUSC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7541
p.W2437C	DO231997	ORCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.S2431A	DO229259	THCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7588
p.T2426M	DO229216	THCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7423
p.H2416N	DO42177	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.T2423M	SIDM02039	Colorectal Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.T2423A	SIDM01045	Endometrial Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.T2423A	EN	endometrium	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.T2432M	SIDM00003	Melanoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.6312
p.T2432M	SIDM00214	Colorectal Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.6312
p.T2432M	SIDM00640	Mesothelioma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.6312
p.T2432M	SNU-407	large_intestine	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.6312
p.T2432M	M14	skin	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.6312
p.T2432M	MSTO-211H	pleura	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.6312
p.A2424S	SIDM00793	Burkitt's Lymphoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.A2424S	SIDM01133	Other Solid Cancers	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.M2425I	SIDM00217	Colorectal Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.M2425I	ACH-000999	Colon/Colorectal Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.M2425I	SNU-1040	large_intestine	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.I2435N	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.I2435N	ACH-000852	Lung Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.I2435N	NCI-H1435	lung	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.A2419T	SIDM01608	Endometrial Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1389
p.S2422F	SIDM01617	Endometrial Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSTPGTT

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of PSSTPGTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	1897:1904	PSSTPGTT	FBXW7	0.9969	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2149:2156	PSSTPGTT	FBXW7	0.6671	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2426:2433	PSSTPGTT	FBXW7	0.9861	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2455:2462	PSSTPGTT	FBXW7	0.9933	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2706:2713	PSSTPGTT	FBXW7	0.7565	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2983:2990	PSSTPGTT	FBXW7	0.9197	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3406:3413	PSSTPGTT	FBXW7	0.7565	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3683:3690	PSSTPGTT	FBXW7	0.9796	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3712:3719	PSSTPGTT	FBXW7	0.9972	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3963:3970	PSSTPGTT	FBXW7	0.9055	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4240:4247	PSSTPGTT	FBXW7	0.9361	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4382:4389	PSSTPGTT	FBXW7	0.9969	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4440:4447	PSSTPGTT	FBXW7	0.9266	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4696:4703	PSSTPGTT	FBXW7	0.685	More...