DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 2983:2990

E3 ligase: FBXW7

DEGRON score: 0.9197

ASA_SCORE: 82.5

COIL: 0.9211

CONS_SCORE: 0.311

DSS_SCORE: 0.5706

HELIX: 0.0181

FCONS_SCORE: 1.0544

RIG_SCORE: 0.6769

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2974N	TCGA-63-7020	LUSC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.0833
p.T2980M	TCGA-66-2787	LUSC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.T2980M	TCGA-BS-A0U8	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.S2985C	TCGA-98-A53I	LUSC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.643
p.A2981T	TCGA-A6-2686	COAD	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.G2988V	TCGA-EE-A29D	SKCM	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.6421
p.W2991R	TCGA-HU-A4GX	STAD	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.S2978G	TCGA-P4-A5E7	KIRP	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.A2984T	DO7828	COAD	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7139
p.E2998K	DO233900	GACA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.S2981G	DO48479	KIRP	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.2778
p.P2978T	DO228806	LICA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.T2983M	DO26647	LUSC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7423
p.T2983M	DO41380	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7423
p.S2988C	DO219182	LUSC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7541
p.T2977N	DO27596	LUSC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.G2991V	DO38123	SKCM	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.W2994R	DO47757	STAD	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.T2989M	SIDM00623	Other Blood Cancers	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.6312
p.T2989M	SIDM01761	Rhabdomyosarcoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.6312
p.S2979C	SIDM00767	Small Cell Lung Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.S2979C	ACH-001136	Lung Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.S2979C	NCI-H187	lung	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.T2994I	SIDM00767	Small Cell Lung Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.T2994I	ACH-001136	Lung Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.T2994I	NCI-H187	lung	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.P2983H	SIDM00233	T-Lymphoblastic Leukemia	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.7694
p.P2983H	ACH-002058	Leukemia	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.7694
p.P2983H	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.7694
p.S2978N	SIDM01525	Acute Myeloid Leukemia	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.S2978R	SIDM01525	Acute Myeloid Leukemia	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.A2981V	ACH-000954	Endometrial/Uterine Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSTPGTT

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of PSSTPGTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	1897:1904	PSSTPGTT	FBXW7	0.9969	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2149:2156	PSSTPGTT	FBXW7	0.6671	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2426:2433	PSSTPGTT	FBXW7	0.9861	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2455:2462	PSSTPGTT	FBXW7	0.9933	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2706:2713	PSSTPGTT	FBXW7	0.7565	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2983:2990	PSSTPGTT	FBXW7	0.9197	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3406:3413	PSSTPGTT	FBXW7	0.7565	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3683:3690	PSSTPGTT	FBXW7	0.9796	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3712:3719	PSSTPGTT	FBXW7	0.9972	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3963:3970	PSSTPGTT	FBXW7	0.9055	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4240:4247	PSSTPGTT	FBXW7	0.9361	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4382:4389	PSSTPGTT	FBXW7	0.9969	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4440:4447	PSSTPGTT	FBXW7	0.9266	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4696:4703	PSSTPGTT	FBXW7	0.685	More...