DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 3683:3690

E3 ligase: FBXW7

DEGRON score: 0.9796

ASA_SCORE: 79

COIL: 0.8991

CONS_SCORE: 0.3227

DSS_SCORE: 0.5171

HELIX: 0.0235

FCONS_SCORE: 1.082

RIG_SCORE: 0.684

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3687L	TCGA-04-1652	OV	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.P3687L	TCGA-BS-A0UV	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.P3687L	TCGA-BT-A20J	BLCA	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.P3687L	TCGA-N7-A4Y0	UCS	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.G3688E	TCGA-37-4132	LUSC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.6087
p.G3688E	TCGA-P3-A6T7	HNSC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.6087
p.T3674N	TCGA-95-7567	LUAD	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.0833
p.T3682M	TCGA-A2-A0SV	BRCA	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.T3682M	OCI-AML2	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.T3682M	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.T3682M	GI-ME-N	autonomic_ganglia	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.T3680M	TCGA-CM-6162	COAD	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.T3680M	TCGA-DU-6392	LGG	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.T3680M	SIDM00602	Gastric Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.A3700T	TCGA-DA-A1I7	SKCM	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.A3700T	TCGA-EE-A2GN	SKCM	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.T3677A	TCGA-EY-A1GD	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.K3695E	TCGA-LA-A7SW	LUSC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.K3695E	SIDM00499	Prostate Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.K3695E	SIDM00555	Glioblastoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.K3695E	SIDM00095	Glioblastoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.K3695E	SNB75	central_nervous_system	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.K3695E	KS-1	central_nervous_system	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.P3690L	DO457	BLCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.P3690L	DO29248	OV	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.P3690L	DO42793	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7582
p.T3685M	DO1914	BRCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7423
p.P3675H	DO49894	CESC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.T3683M	DO8479	COAD	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7423
p.T3683M	DO48270	ESCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7423
p.T3683M	DO22237	LGG	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7423
p.G3691E	DO49033	HNSC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.G3691E	DO26528	LUSC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.G3691E	DO222415	MELA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.W3694C	DO229045	LICA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.T3677N	DO25564	LUAD	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.K3698E	DO52024	LUSC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.T3680A	DO42129	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.T3680A	SIDM00845	Burkitt's Lymphoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.T3680A	SIDM00846	Cervical Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.T3680A	SIDM00760	Small Cell Lung Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.T3680A	SIDM01525	Acute Myeloid Leukemia	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.T3697I	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1389
p.T3697I	ACH-000628	Lung Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.1389
p.T3697I	NCI-H596	lung	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.1389
p.S3685L	SIDM00774	Breast Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.6556
p.S3685L	ACH-000691	Breast Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.6556
p.S3685L	HCC2157	breast	COSMIC	PSSTPGTT	DEG_SCF_FBW7_1	0.6556
p.S3678R	ACH-000312	Neuroblastoma	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSTPGTT

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of PSSTPGTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	1897:1904	PSSTPGTT	FBXW7	0.9969	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2149:2156	PSSTPGTT	FBXW7	0.6671	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2426:2433	PSSTPGTT	FBXW7	0.9861	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2455:2462	PSSTPGTT	FBXW7	0.9933	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2706:2713	PSSTPGTT	FBXW7	0.7565	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2983:2990	PSSTPGTT	FBXW7	0.9197	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3406:3413	PSSTPGTT	FBXW7	0.7565	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3683:3690	PSSTPGTT	FBXW7	0.9796	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3712:3719	PSSTPGTT	FBXW7	0.9972	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3963:3970	PSSTPGTT	FBXW7	0.9055	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4240:4247	PSSTPGTT	FBXW7	0.9361	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4382:4389	PSSTPGTT	FBXW7	0.9969	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4440:4447	PSSTPGTT	FBXW7	0.9266	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4696:4703	PSSTPGTT	FBXW7	0.685	More...