DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 2706:2713

E3 ligase: FBXW7

DEGRON score: 0.7565

ASA_SCORE: 90.075

COIL: 0.9589

CONS_SCORE: 0.3329

DSS_SCORE: 0.6903

HELIX: 0.0098

FCONS_SCORE: 0.8925

RIG_SCORE: 0.595

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2698M	TCGA-04-1652	OV	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.T2698M	SIDM00901	Endometrial Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.T2698M	ACH-000971	Colon/Colorectal Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.A2697T	DO49095	COAD	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.0833
p.A2697T	DO42713	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.0833
p.T2701M	DO29248	OV	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.T2723S	DO52412	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons