DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 2455:2462

E3 ligase: FBXW7

DEGRON score: 0.9933

ASA_SCORE: 85.725

COIL: 0.926

CONS_SCORE: 0.4098

DSS_SCORE: 0.6589

HELIX: 0.015

FCONS_SCORE: 1.1973

RIG_SCORE: 0.681

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2469N	TCGA-A5-A0G2	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.1389
p.T2445M	TCGA-BK-A6W3	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.T2445M	TCGA-D5-6928	COAD	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.T2452M	TCGA-HT-8564	LGG	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.25
p.T2448M	DO7776	COAD	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1389
p.T2448M	DO50076	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1389
p.T2455M	DO44623	LGG	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7423
p.S2472N	DO41235	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.T2446A	SIDM01611	Endometrial Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons