DegronMD

Degron: PSSTPGTT

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 3963:3970

E3 ligase: FBXW7

DEGRON score: 0.9055

ASA_SCORE: 90.8875

COIL: 0.9685

CONS_SCORE: 0.309

DSS_SCORE: 0.6859

HELIX: 0.0086

FCONS_SCORE: 1.0483

RIG_SCORE: 0.597

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N3965T	DO219879	SKCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.7055
p.T3958M	DO41542	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.T3955M	TCGA-AJ-A3EL	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.1111

Showing 1 to 3 of 3 entries

Drug responses associated with MUC5B mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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All proteins holding degron of PSSTPGTT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	1897:1904	PSSTPGTT	FBXW7	0.9969	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2149:2156	PSSTPGTT	FBXW7	0.6671	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2426:2433	PSSTPGTT	FBXW7	0.9861	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2455:2462	PSSTPGTT	FBXW7	0.9933	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2706:2713	PSSTPGTT	FBXW7	0.7565	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2983:2990	PSSTPGTT	FBXW7	0.9197	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3406:3413	PSSTPGTT	FBXW7	0.7565	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3683:3690	PSSTPGTT	FBXW7	0.9796	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3712:3719	PSSTPGTT	FBXW7	0.9972	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3963:3970	PSSTPGTT	FBXW7	0.9055	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4240:4247	PSSTPGTT	FBXW7	0.9361	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4382:4389	PSSTPGTT	FBXW7	0.9969	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4440:4447	PSSTPGTT	FBXW7	0.9266	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4696:4703	PSSTPGTT	FBXW7	0.685	More...

Showing 1 to 14 of 14 entries