DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 3406:3413

E3 ligase: FBXW7

DEGRON score: 0.7565

ASA_SCORE: 90.275

COIL: 0.9589

CONS_SCORE: -249.8052

DSS_SCORE: 0.6903

HELIX: 0.0086

FCONS_SCORE: 0.4997

RIG_SCORE: 0.595

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3396M	TCGA-AX-A2HG	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.N3405D	TCGA-FI-A2D5	UCEC	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.S3402F	TCGA-GM-A2D9	BRCA	TCGA	PSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.T3398N	DO2665	BRCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1111
p.S3405F	DO4810	BRCA	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.N3408D	DO41331	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.6932
p.T3399M	DO41337	UCEC	ICGC	PSSTPGTT	DEG_SCF_FBW7_1	0.1389
p.P3414H	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.P3406R	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.7512
p.A3423T	SIDM00272	Breast Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.P3410Q	SIDM00770	Small Cell Lung Carcinoma	GDSC	PSSTPGTT	DEG_SCF_FBW7_1	0.7035
p.P3410Q	ACH-000559	Lung Cancer	CCLE	PSSTPGTT	DEG_SCF_FBW7_1	0.7035

DegronMD: protein-targeted degradation, mutation and drug response to degrons