Group: TKL
Parent of:
STKR , RIPK , RAF , MLK , IRAK , LISK , LRRK , TKL-Unique ,
Description:
Tyrosine Kinase-like group. This is the most diverse of all groups, apart from the 'Other' group. Families in this group are all close to tyrosine kinases, but are somewhat closer to each other, hence the name
Kinase with G-loop mutations in Group:TKL
Uniprot ID
Gene symbol
Gatekeeper location
G loop location
A loop location
αC-Helix location
Q04771 ACVR1 [N/A] [N/A] 214...220 239...241 P37023 ACVRL1 277 347...374 209...216 233...235 O00238 BMPR1B 279 349...376 211...218 235...237 Q13873 BMPR2 279 350...360, 369...381 209...215 234...236 P15056 BRAF [N/A] [N/A] 464...471 492...506 Q9NWZ3 IRAK4 262 328...340, 342...353 192...198 226...239 P53667 LIMK1 413 477...489, 497...514 344...351 375...388 Q12852 MAP3K12 190 253...275 132...139 157...160 Q9NYL2 MAP3K20 82 150...171 19...31 22...25 O43318 MAP3K7 [N/A] [N/A] 41...48 70...83 P80192 MAP3K9 220 293...314 151...158 185...197 P36897 TGFBR1 [N/A] [N/A] 211...217 236...238 P37173 TGFBR2 325 396...423 250...259 281...283 Q59H18 TNNI3K 539 605...629 468...475 502...515