Group: TKL
Parent of:
STKR , RIPK , RAF , MLK , IRAK , LISK , LRRK , TKL-Unique ,
Description:
Tyrosine Kinase-like group. This is the most diverse of all groups, apart from the 'Other' group. Families in this group are all close to tyrosine kinases, but are somewhat closer to each other, hence the name
Kinase with mutated hotspots in Group:TKL
Uniprot ID
Gene symbol
Gatekeeper location
G loop location
A loop location
αC-Helix location
Q04771 ACVR1 [N/A] [N/A] 214...220 239...241 P36896 ACVR1B 282 352...379 [N/A] [N/A] Q8NER5 ACVR1C 270 340...367 [N/A] [N/A] P27037 ACVR2A [N/A] [N/A] [N/A] 223...225 Q13705 ACVR2B 265 338...363 [N/A] 221...223 P37023 ACVRL1 277 347...374 209...216 233...235 Q16671 AMHR2 279 350...360, 373...385 [N/A] [N/A] P10398 ARAF 382 446...471 [N/A] [N/A] P36894 BMPR1A 309 379...406 [N/A] [N/A] O00238 BMPR1B 279 349...376 211...218 235...237 Q13873 BMPR2 279 350...360, 369...381 209...215 234...236 P15056 BRAF [N/A] [N/A] 464...471 492...506 Q13418 ILK 269 [N/A] [N/A] 229...238 P51617 IRAK1 288 [N/A] [N/A] [N/A] Q9Y616 IRAK3 241 [N/A] [N/A] [N/A] Q9NWZ3 IRAK4 262 328...340, 342...353 192...198 226...239 P53667 LIMK1 413 477...489, 497...514 344...351 375...388 P53671 LIMK2 405 468...511 [N/A] 367...375 Q38SD2 LRRK1 1334 1408...1429 [N/A] [N/A] Q02779 MAP3K10 [N/A] 247...268 [N/A] [N/A] Q16584 MAP3K11 193 266...287 [N/A] [N/A] Q12852 MAP3K12 190 253...275 132...139 157...160 O43283 MAP3K13 233 296...318 [N/A] [N/A] Q9NYL2 MAP3K20 82 150...171 19...31 22...25 O43318 MAP3K7 [N/A] [N/A] 41...48 70...83 P80192 MAP3K9 220 293...314 151...158 185...197 Q8NB16 MLKL [N/A] [N/A] [N/A] 198...201 P04049 RAF1 421 485...510 [N/A] [N/A] Q13546 RIPK1 [N/A] [N/A] [N/A] 54...56 O43353 RIPK2 95 163...191 [N/A] 59...72 Q9Y572 RIPK3 94 [N/A] [N/A] [N/A] Q15569 TESK1 129 195...205, 209...222 [N/A] [N/A] Q96S53 TESK2 130 196...206, 208...221 [N/A] [N/A] P36897 TGFBR1 [N/A] [N/A] 211...217 236...238 P37173 TGFBR2 325 396...423 250...259 281...283 Q59H18 TNNI3K 539 605...629 468...475 502...515