SZGR2

Summary ?

GeneID	1026
Symbol	CDKN1A
Synonyms	CAP20\|CDKN1\|CIP1\|MDA-6\|P21\|SDI1\|WAF1\|p21CIP1
Description	cyclin-dependent kinase inhibitor 1A
Reference	MIM:116899\|HGNC:HGNC:1784\|Ensembl:ENSG00000124762\|HPRD:00298\|Vega:OTTHUMG00000014603
Gene type	protein-coding
Map location	6p21.2
Pascal p-value	0.948
Sherlock p-value	0.393
Fetal beta	-1.715
DMG	1 (# studies)
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I	Genome scan meta-analysis	Psr: 0.033
GSMA_IIE	Genome scan meta-analysis (European-ancestry samples)	Psr: 0.04433
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.1164

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg04214946	6	36651933	CDKN1A	4.312E-4	0.417	0.045	DMG:Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs9985704	chr4	7050376	CDKN1A	1026	0.19	trans
rs317714	chr7	29115553	CDKN1A	1026	0.01	trans
rs4921994	chr8	18954801	CDKN1A	1026	0.11	trans
rs11019015	chr11	90157517	CDKN1A	1026	0.13	trans
rs2993290	chr13	113647189	CDKN1A	1026	0.18	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ANKRD13D	0.88	0.85
SYT3	0.86	0.83
MGAT4B	0.85	0.86
ACOT7	0.85	0.83
PIP5KL1	0.83	0.78
RTN2	0.83	0.85
AC011479.2	0.83	0.81
FKBP1B	0.82	0.81
CRIP2	0.82	0.86
AC024575.2	0.82	0.86

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.8	-0.62	-0.62
AF347015.33	-0.62	-0.62
AF347015.27	-0.60	-0.62
AF347015.26	-0.60	-0.63
MT-CO2	-0.60	-0.58
AF347015.15	-0.59	-0.59
MT-CYB	-0.58	-0.58
MT-ATP8	-0.58	-0.64
AF347015.2	-0.57	-0.57
AF347015.21	-0.57	-0.58

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004861	cyclin-dependent protein kinase inhibitor activity	EXP		10323868
GO:0004861	cyclin-dependent protein kinase inhibitor activity	IEA		-
GO:0004861	cyclin-dependent protein kinase inhibitor activity	TAS		8242751
GO:0004860	protein kinase inhibitor activity	IEA		-
GO:0008270	zinc ion binding	IEA		-
GO:0016301	kinase activity	IEA		-
GO:0030332	cyclin binding	IEA		-
GO:0046872	metal ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000082	G1/S transition of mitotic cell cycle	IDA		10208428
GO:0000086	G2/M transition of mitotic cell cycle	IMP		17553787
GO:0007050	cell cycle arrest	IEA		-
GO:0008285	negative regulation of cell proliferation	IEA		-
GO:0008629	induction of apoptosis by intracellular signals	TAS		9660939
GO:0009411	response to UV	IEA		-
GO:0006974	response to DNA damage stimulus	IEA		-
GO:0043066	negative regulation of apoptosis	IEA		-
GO:0042326	negative regulation of phosphorylation	IDA		10208428
GO:0043071	positive regulation of non-apoptotic programmed cell death	IEA		-
GO:0030890	positive regulation of B cell proliferation	IEA		-
GO:0030308	negative regulation of cell growth	IDA		10208428
GO:0031668	cellular response to extracellular stimulus	IMP		17553787
GO:0045736	negative regulation of cyclin-dependent protein kinase activity	IEA		-
GO:0048146	positive regulation of fibroblast proliferation	IMP		17420273
GO:0051726	regulation of cell cycle	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IEA		-
GO:0005829	cytosol	EXP		9106657 \|9632134
GO:0005829	cytosol	IEA		-
GO:0005634	nucleus	IEA		-
GO:0005654	nucleoplasm	EXP		9190208 \|9632134 \|9840943 \|10323868 \|11231585 \|11931757 \|16782892
GO:0005737	cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APEX1	APE \| APE-1 \| APE1 \| APEN \| APEX \| APX \| HAP1 \| REF-1 \| REF1	APEX nuclease (multifunctional DNA repair enzyme) 1	Ref1 interacts weakly with p21 promoter.	BIND	15674341
BCCIP	TOK-1 \| TOK1	BRCA2 and CDKN1A interacting protein	-	HPRD,BioGRID	10878006 \|14726710
C7orf20	CEE \| CGI-20	chromosome 7 open reading frame 20	Two-hybrid	BioGRID	16169070
CCDC85B	DIPA	coiled-coil domain containing 85B	Two-hybrid	BioGRID	16189514
CCNA1	-	cyclin A1	cyclin A1 interacts with p21.	BIND	10022926
CCNA2	CCN1 \| CCNA	cyclin A2	p21 interacts with cyclin A.	BIND	9632134
CCNA2	CCN1 \| CCNA	cyclin A2	cyclin A interacts with p21. This interaction was modeled on a demonstrated interaction between monkey cyclin A and monkey p21.	BIND	16009130
CCNA2	CCN1 \| CCNA	cyclin A2	CDKN1A (p21) interacts with CCNA2 (cyclin A).	BIND	8662825
CCNA2	CCN1 \| CCNA	cyclin A2	Affinity Capture-Western	BioGRID	12947099
CCNB1	CCNB	cyclin B1	CDKN1A (p21) interacts with CCNB1 (cyclin B1).	BIND	8662825
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	-	HPRD,BioGRID	7478582 \|8657154
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	p21 interacts with cyclin D.	BIND	9632134
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	Cyclin D1 interacts with p21.	BIND	8999999
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	CDKN1A (p21) interacts with CCND1 (cyclin D1).	BIND	8662825
CCND2	KIAK0002 \| MGC102758	cyclin D2	Two-hybrid	BioGRID	16189514
CCND3	-	cyclin D3	Two-hybrid	BioGRID	16189514
CCNE1	CCNE	cyclin E1	p21 interacts with cyclin E.	BIND	9632134
CCNE1	CCNE	cyclin E1	Affinity Capture-Western	BioGRID	12839982
CCNE1	CCNE	cyclin E1	CDKN1A (p21) interacts with CCNE1 (cyclin E).	BIND	8662825
CDC2	CDC28A \| CDK1 \| DKFZp686L20222 \| MGC111195	cell division cycle 2, G1 to S and G2 to M	p21 interacts with CDC2. This interaction was modeled on a demonstrated interaction between human p21 and hamster CDC2.	BIND	9467962
CDC7	CDC7L1 \| HsCDC7 \| Hsk1 \| MGC117361 \| MGC126237 \| MGC126238 \| huCDC7	cell division cycle 7 homolog (S. cerevisiae)	-	HPRD	15232106
CDK2	p33(CDK2)	cyclin-dependent kinase 2	p21WAF1 interacts with an unspecified isoform of Cdk2. This interaction was modelled on a demonstrated interaction between human p21WAF1 and Cdk2 from an unspecified species.	BIND	7780738
CDK2	p33(CDK2)	cyclin-dependent kinase 2	p21 interacts with an unspecified isoform of Cdk2.	BIND	11302688
CDK2	p33(CDK2)	cyclin-dependent kinase 2	p21 interacts with CDK2. This interaction was modeled on a demonstrated interaction between human p21 and hamster CDK2.	BIND	9467962
CDK2	p33(CDK2)	cyclin-dependent kinase 2	p21 interacts with Cdk2.	BIND	9546435
CDK2	p33(CDK2)	cyclin-dependent kinase 2	-	HPRD,BioGRID	12839982
CDK4	CMM3 \| MGC14458 \| PSK-J3	cyclin-dependent kinase 4	Cdk4 interacts with p21.	BIND	8999999
CDKN1B	CDKN4 \| KIP1 \| MEN1B \| MEN4 \| P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	-	HPRD	9858585
CHEK1	CHK1	CHK1 checkpoint homolog (S. pombe)	Affinity Capture-Western	BioGRID	11896572
CIZ1	LSFR1 \| NP94 \| ZNF356	CDKN1A interacting zinc finger protein 1	-	HPRD,BioGRID	10529385
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	CREBBP (CBP) interacts with the p21 promoter.	BIND	15710329
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	CBP interacts with p21.	BIND	10764767
CSNK2A1	CK2A1 \| CKII	casein kinase 2, alpha 1 polypeptide	-	HPRD	11255227
CSNK2B	CK2B \| CK2N \| CSK2B \| G5A \| MGC138222 \| MGC138224	casein kinase 2, beta polypeptide	-	HPRD,BioGRID	10679299
DDX5	DKFZp686J01190 \| G17P1 \| HLR1 \| HUMP68 \| p68	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	p68 interacts with the p21 promoter.	BIND	15660129
FOXO1	FKH1 \| FKHR \| FOXO1A	forkhead box O1	FoxO1 binds the distal region of the p21Cip1 promoter. This interaction was modelled on a demonstrated interaction between FoxO1 from an unspecified species and p21Cip1 promoter from an unspecified species.	BIND	15084259
FOXO3	AF6q21 \| DKFZp781A0677 \| FKHRL1 \| FKHRL1P2 \| FOXO2 \| FOXO3A \| MGC12739 \| MGC31925	forkhead box O3	FoxO3 binds the distal region of the p21Cip1 promoter.	BIND	15084259
FOXO4	AFX \| AFX1 \| MGC120490 \| MLLT7	forkhead box O4	FoxO4 binds the distal region of the p21Cip1 promoter. This interaction was modelled on a demonstrated interaction between FoxO4 from an unspecified species and p21Cip1 promoter from an unspecified species.	BIND	15084259
GADD45A	DDIT1 \| GADD45	growth arrest and DNA-damage-inducible, alpha	-	HPRD	7478594 \|11498536
GADD45A	DDIT1 \| GADD45	growth arrest and DNA-damage-inducible, alpha	Affinity Capture-Western Reconstituted Complex	BioGRID	10912791 \|10973963
GADD45B	DKFZp566B133 \| GADD45BETA \| MYD118	growth arrest and DNA-damage-inducible, beta	-	HPRD	8700517
GADD45G	CR6 \| DDIT2 \| GADD45gamma \| GRP17	growth arrest and DNA-damage-inducible, gamma	-	HPRD,BioGRID	10455148
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	Two-hybrid	BioGRID	16169070
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	HDAC1 interacts with the p21 promoter.	BIND	15710329
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	HDAC1 interacts with the CDKN1A (p21) promoter.	BIND	15674334
HDAC11	FLJ22237	histone deacetylase 11	Two-hybrid	BioGRID	16169070
HERC5	CEB1 \| CEBP1	hect domain and RLD 5	Reconstituted Complex	BioGRID	10581175
HIF1A	HIF-1alpha \| HIF1 \| HIF1-ALPHA \| MOP1 \| PASD8	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	HIF-1alpha interacts with CDKN1A promoter.	BIND	15780936
HIST4H4	H4/p \| MGC24116	histone cluster 4, H4	HIST4H4 (H4) interacts with the CDKN1A promoter.	BIND	15765097
HIST4H4	H4/p \| MGC24116	histone cluster 4, H4	HIST4H4 (H4) interacts with the p21 promoter.	BIND	15710329
MAP3K5	ASK1 \| MAPKKK5 \| MEKK5	mitogen-activated protein kinase kinase kinase 5	Affinity Capture-Western	BioGRID	12820963
MDM2	HDMX \| MGC71221 \| hdm2	Mdm2 p53 binding protein homolog (mouse)	Mdm2 interacts with the p21 promoter.	BIND	15546622
MED1	CRSP1 \| CRSP200 \| DRIP205 \| DRIP230 \| MGC71488 \| PBP \| PPARBP \| PPARGBP \| RB18A \| TRAP220 \| TRIP2	mediator complex subunit 1	MED1 interacts with p21 promoter.	BIND	15989967
MED21	SRB7 \| SURB7	mediator complex subunit 21	MED21 interacts with p21 promoter.	BIND	15989967
MITF	MI \| WS2A \| bHLHe32	microphthalmia-associated transcription factor	An unspecified isoform of Mitf interacts with the p21 promoter.	BIND	15716956
MUC1	CD227 \| EMA \| H23AG \| MAM6 \| PEM \| PEMT \| PUM	mucin 1, cell surface associated	MUC1 C-ter interacts with the p21 promoter.	BIND	15710329
MYC	bHLHe39 \| c-Myc	v-myc myelocytomatosis viral oncogene homolog (avian)	Myc interacts with CDKN1A promoter.	BIND	15780936
MYC	bHLHe39 \| c-Myc	v-myc myelocytomatosis viral oncogene homolog (avian)	c-Myc binds the proximal region of the p21Cip1 promoter.	BIND	15084259
MYC	bHLHe39 \| c-Myc	v-myc myelocytomatosis viral oncogene homolog (avian)	c-Myc interacts with p21WAF1 promoter.	BIND	15856024
PARP1	ADPRT \| ADPRT1 \| PARP \| PARP-1 \| PPOL \| pADPRT-1	poly (ADP-ribose) polymerase 1	-	HPRD,BioGRID	12930846
PCNA	MGC8367	proliferating cell nuclear antigen	CDKN1A (p21) interacts with PCNA.	BIND	8662825
PCNA	MGC8367	proliferating cell nuclear antigen	p21WAF1 interacts with PCNA.	BIND	7780738
PCNA	MGC8367	proliferating cell nuclear antigen	PCNA interacts with p21.	BIND	9705499
PCNA	MGC8367	proliferating cell nuclear antigen	PCNA interacts with p21.	BIND	9178907
PCNA	MGC8367	proliferating cell nuclear antigen	p21 interacts with PCNA.	BIND	11302688
PCNA	MGC8367	proliferating cell nuclear antigen	PCNA interacts with p21.	BIND	8861969
PCNA	MGC8367	proliferating cell nuclear antigen	p21 interacts with PCNA.	BIND	9632134
PCNA	MGC8367	proliferating cell nuclear antigen	p21 interacts with PCNA. This interaction was modeled on a demonstrated interaction between human p21 and PCNA from an unspecified species.	BIND	9546435
PCNA	MGC8367	proliferating cell nuclear antigen	-	HPRD,BioGRID	8861913
PCNA	MGC8367	proliferating cell nuclear antigen	p21WAF1 interacts with PCNA. This interaction was modeled on a demonstrated interaction between human p21WAF1 and Pisum sativum v. Onward PCNA.	BIND	8647134
PCNA	MGC8367	proliferating cell nuclear antigen	p21 interacts with PCNA. This interaction was modeled on a demonstrated interaction between human p21 and hamster PCNA.	BIND	9467962
PIAS2	MGC102682 \| MIZ1 \| PIASX \| PIASX-ALPHA \| PIASX-BETA \| SIZ2 \| ZMIZ4 \| miz	protein inhibitor of activated STAT, 2	Miz1 interacts with p-P21CIP1.	BIND	15580267
PIAS2	MGC102682 \| MIZ1 \| PIASX \| PIASX-ALPHA \| PIASX-BETA \| SIZ2 \| ZMIZ4 \| miz	protein inhibitor of activated STAT, 2	Miz-1 interacts with CDKN1A promoter.	BIND	15780936
PIM1	PIM	pim-1 oncogene	-	HPRD,BioGRID	12431783
POLD2	-	polymerase (DNA directed), delta 2, regulatory subunit 50kDa	-	HPRD	12522211
POLD2	-	polymerase (DNA directed), delta 2, regulatory subunit 50kDa	Waf1 interacts with p50 subunit of DNA polymerase delta.	BIND	12522211
PSMA3	HC8 \| MGC12306 \| MGC32631 \| PSC3	proteasome (prosome, macropain) subunit, alpha type, 3	-	HPRD,BioGRID	11350925
RAB1A	DKFZp564B163 \| RAB1 \| YPT1	RAB1A, member RAS oncogene family	Two-hybrid	BioGRID	16169070
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	Rb interacts with the p21 promoter.	BIND	15716956
RNF144B	IBRDC2 \| KIAA0161 \| MGC71786 \| bA528A10.3 \| p53RFP	ring finger 144B	-	HPRD	12853982
SET	2PP2A \| I2PP2A \| IGAAD \| IPP2A2 \| PHAPII \| TAF-I \| TAF-IBETA	SET nuclear oncogene	-	HPRD,BioGRID	12407107
SMAD4	DPC4 \| JIP \| MADH4	SMAD family member 4	Smad4 binds the distal region of the p21Cip1 promoter.	BIND	15084259
SMARCA4	BAF190 \| BRG1 \| FLJ39786 \| SNF2 \| SNF2-BETA \| SNF2L4 \| SNF2LB \| SWI2 \| hSNF2b	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	BRG1 interacts with p21 promoter.	BIND	15780937
SP1	-	Sp1 transcription factor	SP1 interacts with the CDKN1A (p21) promoter.	BIND	15674334
SP1	-	Sp1 transcription factor	Sp1 interacts with CDKN1A promoter.	BIND	15780936
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	-	HPRD,BioGRID	10764767
TEX11	TGC1 \| TSGA3	testis expressed 11	Two-hybrid	BioGRID	16189514
TK1	TK2	thymidine kinase 1, soluble	-	HPRD,BioGRID	11389691
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	p53 interacts with p21 promoter.	BIND	16009130
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	TP53 (p53) interacts with the CDKN1A (p21) promoter.	BIND	15674334
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	p53 interacts with the p21 promoter.	BIND	15660129
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Affinity Capture-Western	BioGRID	11896572
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	p53 interacts with p21 promoter.	BIND	15989967
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	p53 interacts with the p21 promoter.	BIND	15710329
TP73	P73	tumor protein p73	p73-beta interacts with p21 promoter. This interaction was modeled on a demonstrated interaction between p73-beta from an unspecified species and human p21 promoter.	BIND	15893728
TP73	P73	tumor protein p73	p73-alpha interacts with p21 promoter.	BIND	15893728
TSG101	TSG10 \| VPS23	tumor susceptibility gene 101	-	HPRD,BioGRID	11943869
ZBTB17	MIZ-1 \| ZNF151 \| ZNF60 \| pHZ-67	zinc finger and BTB domain containing 17	Miz1 interacts with p21WAF1 promoter.	BIND	15856024

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG ERBB SIGNALING PATHWAY	87	71	All SZGR 2.0 genes in this pathway
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
KEGG P53 SIGNALING PATHWAY	69	45	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG GLIOMA	65	56	All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER	89	75	All SZGR 2.0 genes in this pathway
KEGG MELANOMA	71	57	All SZGR 2.0 genes in this pathway
KEGG BLADDER CANCER	42	33	All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA	73	59	All SZGR 2.0 genes in this pathway
BIOCARTA ATM PATHWAY	20	16	All SZGR 2.0 genes in this pathway
BIOCARTA G1 PATHWAY	28	21	All SZGR 2.0 genes in this pathway
BIOCARTA G2 PATHWAY	24	20	All SZGR 2.0 genes in this pathway
BIOCARTA CELLCYCLE PATHWAY	23	15	All SZGR 2.0 genes in this pathway
BIOCARTA CALCINEURIN PATHWAY	21	17	All SZGR 2.0 genes in this pathway
BIOCARTA EPONFKB PATHWAY	11	11	All SZGR 2.0 genes in this pathway
BIOCARTA P53HYPOXIA PATHWAY	23	21	All SZGR 2.0 genes in this pathway
BIOCARTA RACCYCD PATHWAY	26	23	All SZGR 2.0 genes in this pathway
BIOCARTA P53 PATHWAY	16	13	All SZGR 2.0 genes in this pathway
SA G1 AND S PHASES	15	10	All SZGR 2.0 genes in this pathway
SA G2 AND M PHASES	8	7	All SZGR 2.0 genes in this pathway
SA TRKA RECEPTOR	17	15	All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY	82	63	All SZGR 2.0 genes in this pathway
PID PRL SIGNALING EVENTS PATHWAY	23	17	All SZGR 2.0 genes in this pathway
PID NOTCH PATHWAY	59	49	All SZGR 2.0 genes in this pathway
PID P73PATHWAY	79	59	All SZGR 2.0 genes in this pathway
PID HDAC CLASSIII PATHWAY	25	20	All SZGR 2.0 genes in this pathway
PID E2F PATHWAY	74	48	All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY	50	41	All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY	82	60	All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY	137	94	All SZGR 2.0 genes in this pathway
PID CMYB PATHWAY	84	61	All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY	35	30	All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID TAP63 PATHWAY	54	40	All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY	65	46	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT	78	59	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4	90	67	All SZGR 2.0 genes in this pathway
REACTOME ORC1 REMOVAL FROM CHROMATIN	67	37	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME PI3K EVENTS IN ERBB4 SIGNALING	38	28	All SZGR 2.0 genes in this pathway
REACTOME PI3K EVENTS IN ERBB2 SIGNALING	44	34	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	97	66	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	126	90	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME PI3K AKT ACTIVATION	38	29	All SZGR 2.0 genes in this pathway
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	12	10	All SZGR 2.0 genes in this pathway
REACTOME GAB1 SIGNALOSOME	38	29	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS	124	70	All SZGR 2.0 genes in this pathway
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	65	40	All SZGR 2.0 genes in this pathway
REACTOME G1 PHASE	38	23	All SZGR 2.0 genes in this pathway
REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	57	35	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	95	76	All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION	112	63	All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF DNA	92	53	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES	137	79	All SZGR 2.0 genes in this pathway
REACTOME PI 3K CASCADE	56	39	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION	192	110	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME PIP3 ACTIVATES AKT SIGNALING	29	20	All SZGR 2.0 genes in this pathway
REACTOME S PHASE	109	66	All SZGR 2.0 genes in this pathway
REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	56	34	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
KIM RESPONSE TO TSA AND DECITABINE UP	129	73	All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN	391	222	All SZGR 2.0 genes in this pathway
ZERBINI RESPONSE TO SULINDAC DN	6	5	All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA UP	183	119	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP	473	314	All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP	276	187	All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN	241	146	All SZGR 2.0 genes in this pathway
NEWMAN ERCC6 TARGETS DN	39	24	All SZGR 2.0 genes in this pathway
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP	158	103	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP	233	161	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLACK UP	35	22	All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS DN	240	171	All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP	456	228	All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 UP	64	46	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP	128	95	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP	117	84	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
LAU APOPTOSIS CDKN2A UP	55	40	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP	443	294	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS CDC25 UP	58	39	All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF UP	115	78	All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP	239	157	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP	612	367	All SZGR 2.0 genes in this pathway
CAIRO PML TARGETS BOUND BY MYC DN	14	12	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
KERLEY RESPONSE TO CISPLATIN UP	44	30	All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION UP	126	78	All SZGR 2.0 genes in this pathway
TANG SENESCENCE TP53 TARGETS UP	33	20	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK DN	39	27	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS UP	169	127	All SZGR 2.0 genes in this pathway
NUNODA RESPONSE TO DASATINIB IMATINIB DN	13	10	All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS	1174	695	All SZGR 2.0 genes in this pathway
SANCHEZ MDM2 TARGETS	15	10	All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP	88	58	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2	127	92	All SZGR 2.0 genes in this pathway
SCHAVOLT TARGETS OF TP53 AND TP63	16	12	All SZGR 2.0 genes in this pathway
KOMMAGANI TP63 GAMMA TARGETS	9	7	All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 4NM UP	23	15	All SZGR 2.0 genes in this pathway
AMUNDSON DNA DAMAGE RESPONSE TP53	16	9	All SZGR 2.0 genes in this pathway
SEITZ NEOPLASTIC TRANSFORMATION BY 8P DELETION DN	30	25	All SZGR 2.0 genes in this pathway
MEINHOLD OVARIAN CANCER LOW GRADE UP	19	15	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP	176	111	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP	227	137	All SZGR 2.0 genes in this pathway
MANN RESPONSE TO AMIFOSTINE UP	20	12	All SZGR 2.0 genes in this pathway
MURATA VIRULENCE OF H PILORI	24	16	All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION	149	101	All SZGR 2.0 genes in this pathway
KHETCHOUMIAN TRIM24 TARGETS UP	47	38	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
SCIAN CELL CYCLE TARGETS OF TP53 AND TP73 UP	9	7	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN	382	224	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS MODERATELY DN	110	64	All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN	261	155	All SZGR 2.0 genes in this pathway
FRIDMAN SENESCENCE UP	77	60	All SZGR 2.0 genes in this pathway
FRIDMAN IMMORTALIZATION DN	34	24	All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN	206	136	All SZGR 2.0 genes in this pathway
HE PTEN TARGETS UP	16	15	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 120 HELA	69	47	All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP	223	140	All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE UP	80	54	All SZGR 2.0 genes in this pathway
MORI LARGE PRE BII LYMPHOCYTE UP	86	49	All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE DN	76	52	All SZGR 2.0 genes in this pathway
MORI IMMATURE B LYMPHOCYTE DN	90	55	All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES	230	137	All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS DN	108	84	All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION UP	142	93	All SZGR 2.0 genes in this pathway
KANNAN TP53 TARGETS UP	58	40	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN	309	206	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE UP	60	42	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP	157	105	All SZGR 2.0 genes in this pathway
COLLER MYC TARGETS DN	9	5	All SZGR 2.0 genes in this pathway
LEI MYB TARGETS	318	215	All SZGR 2.0 genes in this pathway
NEMETH INFLAMMATORY RESPONSE LPS UP	88	64	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA UP	64	46	All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD DN	162	102	All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP	214	133	All SZGR 2.0 genes in this pathway
VERNELL RETINOBLASTOMA PATHWAY UP	70	47	All SZGR 2.0 genes in this pathway
MA MYELOID DIFFERENTIATION UP	39	29	All SZGR 2.0 genes in this pathway
ABE VEGFA TARGETS 2HR	34	21	All SZGR 2.0 genes in this pathway
BRACHAT RESPONSE TO CISPLATIN	22	11	All SZGR 2.0 genes in this pathway
WHITESIDE CISPLATIN RESISTANCE UP	11	7	All SZGR 2.0 genes in this pathway
GENTILE UV LOW DOSE UP	27	19	All SZGR 2.0 genes in this pathway
ONGUSAHA TP53 TARGETS	38	23	All SZGR 2.0 genes in this pathway
HARRIS HYPOXIA	81	64	All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS UP	56	35	All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP	206	118	All SZGR 2.0 genes in this pathway
MCDOWELL ACUTE LUNG INJURY UP	45	29	All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 2	50	34	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN	148	102	All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP	244	165	All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN	228	146	All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 6HR UP	37	31	All SZGR 2.0 genes in this pathway
SIMBULAN PARP1 TARGETS UP	31	23	All SZGR 2.0 genes in this pathway
KANG FLUOROURACIL RESISTANCE UP	22	15	All SZGR 2.0 genes in this pathway
DELASERNA MYOD TARGETS UP	89	51	All SZGR 2.0 genes in this pathway
INGA TP53 TARGETS	17	13	All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA	50	31	All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART UP	103	69	All SZGR 2.0 genes in this pathway
BRACHAT RESPONSE TO METHOTREXATE UP	26	16	All SZGR 2.0 genes in this pathway
MACLACHLAN BRCA1 TARGETS UP	21	16	All SZGR 2.0 genes in this pathway
GAJATE RESPONSE TO TRABECTEDIN UP	67	45	All SZGR 2.0 genes in this pathway
DELLA RESPONSE TO TSA AND BUTYRATE	21	17	All SZGR 2.0 genes in this pathway
BRACHAT RESPONSE TO CAMPTOTHECIN UP	28	18	All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP	198	132	All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP	77	57	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C1	72	45	All SZGR 2.0 genes in this pathway
SEMENZA HIF1 TARGETS	36	32	All SZGR 2.0 genes in this pathway
VARELA ZMPSTE24 TARGETS UP	40	30	All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1	419	273	All SZGR 2.0 genes in this pathway
KRIGE AMINO ACID DEPRIVATION	29	20	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP	783	442	All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN	409	268	All SZGR 2.0 genes in this pathway
KANG CISPLATIN RESISTANCE UP	19	11	All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP	282	183	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP	317	208	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP	461	298	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS UP	43	28	All SZGR 2.0 genes in this pathway
OUYANG PROSTATE CANCER MARKERS	19	16	All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS DN	36	21	All SZGR 2.0 genes in this pathway
SAGIV CD24 TARGETS DN	46	26	All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY UP	134	84	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP	245	159	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE	242	168	All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP	198	128	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D UP	139	95	All SZGR 2.0 genes in this pathway
HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS	80	56	All SZGR 2.0 genes in this pathway
REICHERT G1S REGULATORS AS PI3K TARGETS	8	6	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP	338	225	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN	235	144	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN	245	150	All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE DN	209	137	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP	491	316	All SZGR 2.0 genes in this pathway
SWEET KRAS ONCOGENIC SIGNATURE	89	56	All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS KERATINOCYTE UP	91	63	All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP	163	102	All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM LOW RISK UP	22	15	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP	221	150	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP	293	203	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS UP	108	78	All SZGR 2.0 genes in this pathway
MIKKELSEN PARTIALLY REPROGRAMMED TO PLURIPOTENCY	10	6	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME3 AND H3K27ME3	142	103	All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP	181	106	All SZGR 2.0 genes in this pathway
ONO FOXP3 TARGETS DN	42	23	All SZGR 2.0 genes in this pathway
TSAI DNAJB4 TARGETS UP	13	8	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3	210	148	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE LITERATURE	44	25	All SZGR 2.0 genes in this pathway
WU APOPTOSIS BY CDKN1A VIA TP53	55	31	All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP	307	182	All SZGR 2.0 genes in this pathway
QI HYPOXIA	140	96	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN	505	328	All SZGR 2.0 genes in this pathway
WAGSCHAL EHMT2 TARGETS UP	13	7	All SZGR 2.0 genes in this pathway
IVANOVSKA MIR106B TARGETS	90	56	All SZGR 2.0 genes in this pathway
ZHU SKIL TARGETS UP	20	14	All SZGR 2.0 genes in this pathway
KIM PTEN TARGETS UP	18	9	All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN	315	215	All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 2 DN	32	23	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP	682	433	All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7	403	240	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS UP	149	96	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL	160	106	All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS UP	266	142	All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP	489	314	All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 2HR UP	53	33	All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR UP	166	97	All SZGR 2.0 genes in this pathway
GHANDHI DIRECT IRRADIATION UP	110	68	All SZGR 2.0 genes in this pathway
WARTERS RESPONSE TO IR SKIN	83	44	All SZGR 2.0 genes in this pathway
WARTERS IR RESPONSE 5GY	47	23	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-17-5p/20/93.mr/106/519.d	468	474	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-208	86	92	1A	hsa-miR-208	AUAAGACGAGCAAAAAGCUUGU
miR-22	951	957	m8	hsa-miR-22^brain	AAGCUGCCAGUUGAAGAACUGU
miR-499	86	92	1A	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CDKN1A