Gene Page: PDGFB

Summary
GeneID  5155
Symbol  PDGFB
Synonyms  FLJ12858|PDGF2|SIS|SSV|c-sis
Description  platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
See related  HGNC:8800|MIM:190040|Ensembl:ENSG00000100311|HPRD:01815|
Locus tag  -
Gene type  protein-coding
Map location  22q12.3-q13.1|22q13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DUSP70.770.74
DUSP80.760.75
SPEG0.740.71
DENND1A0.730.75
BAI20.730.73
C11orf810.720.76
KIAA06640.720.73
RHOBTB20.710.69
MGAT5B0.710.71
PIP5K1C0.710.70
Top 10 negatively co-expressed genes
SYCP3-0.52-0.54
RPS27L-0.51-0.52
C1orf54-0.49-0.49
GNG11-0.48-0.48
CLEC2B-0.47-0.44
DBI-0.47-0.48
C8orf59-0.47-0.48
MTCP1NB-0.46-0.48
S100A13-0.45-0.38
AF347015.21-0.45-0.43
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005161platelet-derived growth factor receptor bindingNAS1661670 
GO:0005515protein bindingIPI17981115 
GO:0008083growth factor activityIEA-
GO:0048407platelet-derived growth factor bindingIPI7073684 
GO:0042803protein homodimerization activityIDA2836953 
GO:0043498cell surface bindingIDA291037 |2538439 |2836953 
GO:0046982protein heterodimerization activityIPI7073684 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030031cell projection biogenesisIEAaxon (GO term level: 8)-
GO:0001938positive regulation of endothelial cell proliferationIEA-
GO:0010544negative regulation of platelet activationIDA2538439 
GO:0010512negative regulation of phosphatidylinositol biosynthetic processIDA2538439 
GO:0008283cell proliferationIEA-
GO:0009611response to woundingNAS1661670 
GO:0048008platelet-derived growth factor receptor signaling pathwayIDA2439522 |2536956 |2836953 
GO:0006929substrate-bound cell migrationIEA-
GO:0030036actin cytoskeleton organizationIEA-
GO:0014911positive regulation of smooth muscle cell migrationIDA9409235 
GO:0050921positive regulation of chemotaxisIDA9409235 
GO:0030336negative regulation of cell migrationIEA-
GO:0043406positive regulation of MAP kinase activityIDA9685360 
GO:0045740positive regulation of DNA replicationIDA2439522 |2836953 
GO:0048146positive regulation of fibroblast proliferationIDA2439522 
GO:0050730regulation of peptidyl-tyrosine phosphorylationIEA-
GO:0043536positive regulation of blood vessel endothelial cell migrationIDA9685360 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP287022 
GO:0005576extracellular regionNAS1661670 
GO:0016020membraneIEA-
GO:0009986cell surfaceIDA291037 |2836953 |9685360 
GO:0031089platelet dense granule lumenEXP287022 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
A2MCPAMD5 | DKFZp779B086 | FWP007 | S863-7alpha-2-macroglobulin-HPRD10681572 
ART1ART2 | CD296 | MGC133217 | RT6ADP-ribosyltransferase 1-HPRD11498506 
COL1A1OI4collagen, type I, alpha 1-HPRD10446987 
HNRNPCC1 | C2 | HNRNP | HNRPC | MGC104306 | MGC105117 | MGC117353 | MGC131677 | SNRPCheterogeneous nuclear ribonucleoprotein C (C1/C2)-HPRD10409733 
HRASC-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1v-Ha-ras Harvey rat sarcoma viral oncogene homolog-HPRD10485711 
HSPG2PLC | PRCAN | SJA | SJS | SJS1heparan sulfate proteoglycan 2-HPRD,BioGRID9692901 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)-HPRD,BioGRID11854294 
PDAP1HASPP28 | PAP | PAP1PDGFA associated protein 1-HPRD,BioGRID8780057 
PDGFBFLJ12858 | PDGF2 | SIS | SSV | c-sisplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)-HPRD,BioGRID1396586 
PDGFRACD140A | MGC74795 | PDGFR2 | Rhe-PDGFRAplatelet-derived growth factor receptor, alpha polypeptide-HPRD,BioGRID2544881 
PDGFRBCD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1platelet-derived growth factor receptor, beta polypeptide-HPRD11903042 
SPARCONsecreted protein, acidic, cysteine-rich (osteonectin)Reconstituted ComplexBioGRID1311092 
THBS1THBS | TSP | TSP1thrombospondin 1-HPRD,BioGRID9334164 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA 7060All SZGR genes in this pathway
KEGG_GLIOMA 6556All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
KEGG_MELANOMA 7157All SZGR genes in this pathway
PID_PTP1B_PATHWAY 5240All SZGR genes in this pathway
PID_INTEGRIN3_PATHWAY 4325All SZGR genes in this pathway
PID_S1P_S1P3_PATHWAY 2924All SZGR genes in this pathway
PID_NECTIN_PATHWAY 3020All SZGR genes in this pathway
PID_TCPTP_PATHWAY 4333All SZGR genes in this pathway
PID_SHP2_PATHWAY 5846All SZGR genes in this pathway
PID_S1P_S1P1_PATHWAY 2118All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 8956All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 9576All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_DN 4629All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_GREY_DN 7444All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ELVIDGE_HYPOXIA_UP 171112All SZGR genes in this pathway
ELVIDGE_HIF1A_TARGETS_DN 9158All SZGR genes in this pathway
ELVIDGE_HIF1A_AND_HIF2A_TARGETS_DN 10472All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP 185119All SZGR genes in this pathway
STREICHER_LSM1_TARGETS_UP 4434All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_3 4831All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_22 139All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
TAGHAVI_NEOPLASTIC_TRANSFORMATION 1210All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
TENEDINI_MEGAKARYOCYTE_MARKERS 6648All SZGR genes in this pathway
MANALO_HYPOXIA_UP 207145All SZGR genes in this pathway
GALINDO_IMMUNE_RESPONSE_TO_ENTEROTOXIN 8567All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_UP 8961All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
MOREAUX_B_LYMPHOCYTE_MATURATION_BY_TACI_UP 9258All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_HEREDITARY_VS_SPORADIC 5032All SZGR genes in this pathway
HARRIS_HYPOXIA 8164All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
LEONARD_HYPOXIA 4735All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN 271175All SZGR genes in this pathway
CLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_UP 2012All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP 439257All SZGR genes in this pathway
SAGIV_CD24_TARGETS_DN 4626All SZGR genes in this pathway
LABBE_WNT3A_TARGETS_UP 11271All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_UP 10264All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_UP 11170All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
MIZUKAMI_HYPOXIA_DN 65All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN 238145All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 349234All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
DANG_MYC_TARGETS_DN 3125All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3 341243All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
KATSANOU_ELAVL1_TARGETS_UP 169105All SZGR genes in this pathway
HUANG_GATA2_TARGETS_DN 7252All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP 199143All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/98796802m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-29132138m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-496159315991Ahsa-miR-496AUUACAUGGCCAAUCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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