Found 139 literature records

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Entrez ID	Description
5925	Altered structure and deregulated expression of the tumor suppressor gene retinoblastoma (RB1) in human brain tumors.
22943	Dickkopf-1 is an epigenetically silenced candidate tumor suppressor gene in medulloblastoma.
7832	PC3 / BTG2 acts as a tumor suppressor of medulloblastoma by its antiproliferative and prodifferentiative effect on cerebellar progenitors. This antagonizes Shh and appears physiologic since endogenous PC3 / BTG2 decreases in human medulloblastomas.
7832	PC3/Tis21/BTG2 is a tumor suppressor of medulloblastoma
8313	"The pathway is negatively controlled by the tumor suppressor AXIN2 (Conductin), a scaffold protein of this signaling complex."
1316	Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastoma.
2903	NMDAR2A is commonly hypermethylated in primary human colorectal carcinoma and possesses tumor-suppressive activity.
27250	mir-21 functions as an oncogene by a mechanism that involves translational repression of the tumor suppressor Pdcd4
407043	microRNA-7 (miR-7) is a potential tumor suppressor in glioblastoma targeting critical cancer pathways
7157	the human glutathione S-transferase P1 gene is a novel transcriptional target of the p53 tumor suppressor gene
84525	"HOP may work as a tumor suppressor in a subset of glioblastomas; HOP function thus appears to be critical in the adult brain in a region of continued plasticity, and its deregulation may contribute to disease"
5371	The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope.
9521	"Absence of somatic mutation of a tumor suppressor gene eukaryotic translation elongation factor 1, epsilon-1 (EEF1E1), in common human cancers."
10653	data support the role of SPINT2 as a putative tumor suppressor gene in medulloblastoma and further implicate dysregulation of the HGF/MET signaling pathway in the pathogenesis of medulloblastoma
51684	human tumor suppressor SUFU has a role in Hedgehog signaling [review]
57863	finding suggests that NECL1 may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation
57863	suggests that NECL1 may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation
4763	Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model.
5728	Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model.
7157	Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model.
1031	Cdk4 inhibitor p18(Ink4c) is a tumor suppressor in cyclin D1-driven PNET.
1029	Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.
5728	Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.
10612	Loss of heterozygosity of chromosome segment 11p15.5 in malignant gliomas suggests TRIM3 as a candidate brain tumor suppressor gene.
10409	"down-regulation of the BASP1 gene is a necessary event in myc-induced oncogenesis, defining the BASP1 protein as a potential tumor suppressor."
3417	"IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway"
8406	Downregulation of drs tumor suppressor gene in highly malignant human pulmonary neuroendocrine tumors.
5789	These results implicate PTPRD as a tumor suppressor on chromosome 9p that is involved in the development of glioblastoma multiforme and multiple human cancers.
310	Haploinsufficiency of the tumor suppressor ANXA7 due to monosomy of chromosome 10 provides a clinically relevant mechanism to augment EGFR signaling in glioblastomas beyond that resulting from amplification of the EGFR gene.
406983	miR-200a appears to act as a multifunctional tumor suppressor miRNA in meningiomas through effects on the E-cadherin and Wnt/beta-catenin signaling pathways.
56666	Pannexin2 is a tumor suppressor gene in C6 glioma cells.
7157	A molecular mechanism by which hyper-excitation of the stress axis in turn activates the tumor suppressor p53.
7248	"our data suggest that hamartin, which has mainly been regarded as an interaction partner in the tumor suppressor complex (TSC) with tuberin, has a pronounced independent functional relevance in the pathogenetic context of TSC and cortical dysplasias"
9314	Data show that that KLF4 is inactivated by either genetic or epigenetic mechanisms in a large subset of medulloblastomas and that it likely functions as a tumor suppressor gene in the pathogenesis of medulloblastoma.
10472	Findings indicate that ZNF238 is a novel brain tumor suppressor and its reactivation in tumors could open a novel anticancer strategy.
4771	Overexpression of ezrin inactivates NF2 tumor suppressor in glioblastoma.
407040	miR-34a is a tumor suppressor.
6422	The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma.
78986	DUSP26 may function as a tumour suppressor in particular cancers.
407040	"Results demonstrate that miR-34a acts as a tumor suppressor in p53-mutant glioma cells U251, partially through regulating SIRT1."
7157	"Results demonstrate that miR-34a acts as a tumor suppressor in p53-mutant glioma cells U251, partially through regulating SIRT1."
7157	tumor suppressor p53 expression was increased following EphB3 stimulation and is reduced in the absence of either EphB3 or ephrinB3.
84417	Overexpression of candidate tumor suppressor ECRG4 inhibits glioma proliferation and invasion.
5728	"Findings define a tumor suppressor role for NHERF1 at the plasma membrane, and reveal a novel mechanism for PI3K/Akt activation through PTEN inactivation caused by a loss of membrane-localized NHERF1."
9368	"Findings define a tumor suppressor role for NHERF1 at the plasma membrane, and reveal a novel mechanism for PI3K/Akt activation through PTEN inactivation caused by a loss of membrane-localized NHERF1."
8434	The Reck tumor suppressor protein alleviates tissue damage and promotes functional recovery after transient cerebral ischemia in mice.
7157	nuclear Bcl2L12 physically and functionally interacts with the p53 tumor suppressor
644943	This is the first report demonstrating that RASSF10 can act as a tumor suppressor gene and is frequently methylated in gliomas
84651	ECRG2 is a novel member of the Kazal-type serine protease inhibitor family and may function as a tumor suppressor gene regulating the protease cascades during carcinogenesis and invasion of esophageal cancer.
126520	"The human polo-like kinase 5 gene is significantly silenced in astrocytoma and glioblastoma multiforme by promoter hypermethylation, suggesting a tumor suppressor function for this gene."

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