Found 134 literature records

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Entrez ID	Description
4869	Npm1 acts as a haploinsufficient tumor suppressor in the hematopoietic compartment
1029	These findings uncover a feedback regulatory circuit in the astrocytic lineage and demonstrate tumor suppressor role for p18(INK4C) in human glioblastoma wherein it functions cooperatively with other INK4 family.
1031	These findings uncover a feedback regulatory circuit in the astrocytic lineage and demonstrate tumor suppressor role for p18(INK4C) in human glioblastoma wherein it functions cooperatively with other INK4 family.
139285	Tumor suppressor WTX gene mutation is rare in acute leukemias.
406986	"Expression of miR-203 reduces ABL1 and BCR-ABL1 fusion protein levels and inhibits tumor cell proliferation in an ABL1-dependent manner, suggesting it may function as a tumor suppressor."
160728	"In acute myeloid leukemia with mixed lineage leukemia partial tandem duplication, the SLC5A8 tumor suppressor gene promoter was more frequently hypermethylated."
5728	[Expression of tumor suppressor gene pten in patients with myelodysplastic syndrome and acute myeloid leukemia].
4763	A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene.
7428	genetic variants of HIF1A (Hypoxia-inducible factor 1-alpha )and VHL(von Hippel-Lindau tumor suppressor protein) are not associated with acute mountain sickness symptoms that occur in Sherpas at extremely high altitudes
5371	PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage.
407024	MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.
5371	Results provide insight into a dynamic pool of cytoplasmic nucleoporins that form a complex with the tumor suppressor protein PML during the G1 phase of the cell cycle.
7157	Suppression of tumor suppressor p53 functions together with nuclear calcium-regulated neuroprotective genes in a coordinate and synergistic manner to promote neuronal survival through the stabilization of mitochondria against cellular stresses.
7157	"cAMP levels may influence p53 function in malignant cells that retain wt p53, potentially affecting p53 both as a tumor suppressor during cancer initiation and maintenance, and as an effector of the apoptotic response to DNA-damaging agents"
23705	"These results suggest that the conspicuous expression of the tumor suppressor genes BEX2, IGSF4 and TIMP3 in MLLmu acute myeloid leukemias cell lines is the consequence of altered epigenetic properties of MLL fusion proteins."
7078	"These results suggest that the conspicuous expression of the tumor suppressor genes BEX2, IGSF4 and TIMP3 in MLLmu acute myeloid leukemias cell lines is the consequence of altered epigenetic properties of MLL fusion proteins."
84707	"These results suggest that the conspicuous expression of the tumor suppressor genes BEX2, IGSF4 and TIMP3 in MLLmu acute myeloid leukemias cell lines is the consequence of altered epigenetic properties of MLL fusion proteins."
7474	"WNT5A, a putative tumor suppressor gene in acute myeloid leukemia (AML), is silenced by methylation in this disease and that this epigenetic event is associated with upregulation of CYCLIN D1 expression."
2120	"The deleted segment on 12p contains several genes, among the tumor suppressor genes ETV6 and CDKN1B, which are frequently involved in 12p abnormalities in childhood ALL."
5728	PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice.
7249	Suppression of tumor suppressor Tsc2 and DNA repair glycosylase Nth1 during spontaneous liver tumorigenesis in Long-Evans Cinnamon rats.
2050	EPHB4 can function as a tumor suppressor in acute lymphoblastic leukemia
11186	Fluorescent epigenetic small molecule induces expression of the tumor suppressor ras-association domain family 1A and inhibits human prostate xenograft.
54790	"With diverse genetic methods, TET2 on chromosome 4q24 was identified as candidate tumor suppressor gene."
84295	these results identify PHF6 as a new X-linked tumor suppressor in T-ALL and point to a strong genetic interaction between PHF6 loss and aberrant expression of TLX transcription factors in the pathogenesis of this disease.
1030	"new animal model demonstrates experimentally that p15Ink4b is a tumor suppressor for myeloid leukemia, and its loss may play an active role in the establishment of preleukemic conditions"
5771	Our study provides genetic and functional evidence for a tumor suppressor role of PTPN2 and suggests that expression of PTPN2 may modulate response to treatment.
442920	Suggest that miR-196b functions as a tumor suppressor in B-cell lineage acute lymphoblastic leukemia.
7157	the ability of p53 to limit aberrant self-renewal contributes to its tumor suppressor activity
678	ZFP36L2 has a critical role in lymphocyte development and may function as a tumor suppressor.
6794	The LKB1/AMPK/TSC tumor suppressor axis is functional in acute myeloid leukemia.
442920	Functional genomics of tumor suppressor miR-196b in T-cell acute lymphoblastic leukemia.
644943	This is the first report demonstrating that RASSF10 can act as a tumor suppressor gene and is frequently methylated in gliomas
84295	PHF6 as a tumor suppressor gene mutated in acute myeloid leukemias (AML) and extend the role of this X-linked tumor suppressor gene in the pathogenesis of hematologic tumors.
1029	[Expression of ubiquitin associated protein 1 gene and tumor-suppressor gene p16 in acute leukemia].
2120	ETV6 generally plays as tumor-suppressor gene in leukemia.
9046	Mutational analysis of DOK2 tumor suppressor gene in acute leukemias.
1029	"Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies."
4851	"Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies."
574411	Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL.
10217	"MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia."
406935	miR-143 functions as a tumor suppressor in MLL-AF4 B-cell acute lymphoblastic leukemia.
4221	data provide a structural basis for understanding the role of menin as a tumor suppressor protein and as an oncogenic co-factor of mixed lineage leukemia fusion proteins
2322	"The WT FLT3 allele seemingly functions as a tumor suppressor, attenuating the function of the FLT3/ITD allele in leukemia harboring FLT3/ITD mutations."
11010	Identification of GLIPR1 tumor suppressor as methylation-silenced gene in acute myeloid leukemia by microarray analysis.
63035	"BCORL1 by genetic criteria is a novel candidate tumor suppressor gene, joining the growing list of genes recurrently mutated in acute myelogenous leukemia."
1437	A possible tumor-suppressor role of GM-CSF in RUNX1-ETO leukemia.
23512	"study reports presence of loss-of-function mutations and deletions of the EZH2 and SUZ12 genes, which encode components of the Polycomb repressive complex 2 (PRC2), in 25% of T cell acute lymphoblastic leukemias; study suggesst tumor suppressor role for PRC2 in leukemia and suggest a gnized dynamic interplay between oncogenic NOTCH1 and PRC2"
23512	studies suggest a tumor suppressor role for PRC2 in human leukemia and suggest a hitherto unrecognized dynamic interplay between oncogenic NOTCH1 and PRC2 function
3172	"HNF4alpha maintains hepatocyte differentiation in the adult healthy liver, and its loss may directly contribute to hepatocellular carcinoma development, thus indicating this factor as a possible liver tumor suppressor gene."

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