Found 463 literature records

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Entrez ID	Description
6422	"SFRP 1 gene is frequently downregulated by promoter hypermethylation and suppresses tumor growth activity of lung cancer cells, which suggests that SFRP 1 is a candidate tumor suppressor gene for lung cancer"
9077	Association between STAT3 and ARHI as well as the functional inhibition of STAT3 transcriptional activity by ARHI suggests a novel mechanism through which a putative tumor suppressor gene can inhibit STAT3 activity in breast and ovarian cancers.
23705	Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression.
5580	"vascular smooth muscle cell apoptosis proceeds through a pathway that involves PKCdelta, the intermediary p38 MAPK, and the downstream target tumor suppressor p53"
7157	"vascular smooth muscle cell apoptosis proceeds through a pathway that involves PKCdelta, the intermediary p38 MAPK, and the downstream target tumor suppressor p53"
1540	The tumor suppressor familial cylindromatosis gene (CYLD) was found to be a direct target of BAF57 as determined by chromatin immunoprecipitation analysis. (CYLD)
11186	Involvement of the RASSF1A tumor suppressor gene in controlling cell migration.
5580	"PKC-delta inhibits transformed keratinocyte growth by inducing apoptosis, and may function as a tumor suppressor in human SCCs where its loss in cells harboring activated ras could provide a growth advantage by conferring resistance to apoptosis"
9077	E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer.
54971	Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex.
90627	"Results suggest that DLC2 exhibits its tumor suppressor functions in vivo as a GAP specific for RhoA, exerting its effects in suppression of cytoskeleton reorganization, cell growth, cell migration, and transformation."
5925	Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor.
92304	"Studies provide further evidence that HIN-1 possesses tumor suppressor functions, and that these activities may be mediated through the AKT signaling pathway."
23541	"TAP not only mediates vitamin E absorption to facilitate vitamin E antiproliferation effect in prostate cancer cells, but also functions like a tumor suppressor gene to control cancer cell viability through a non-vitamin E manner."
6794	results provide direct evidence that the LKB1 tumor suppressor is the major upstream activating kinase for AMPK in liver
5728	The tumor suppressor PTEN is necessary for human Sprouty 2-mediated inhibition of cell proliferation.
7249	Modulation of cell migration and invasiveness by tumor suppressor TSC2 in lymphangioleiomyomatosis.
5909	data identify rap1GAP as a putative tumor suppressor gene in pancreatic cancer
1676	apoptotic DNA fragmentation factor is required for the maintenance of genetic stability and may play a role in tumor suppression
5728	PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling.
4772	These results demonstrate that the inducible NFAT3-mediated iNOS upregulation represents a novel potent tumor-suppressing pathway and may contribute to the tumor suppressor functions of NFAT protein.
3622	The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation.
23582	"In transgenic mice, GCIP functions as a transcriptional suppressor, regulates cyclin D1 expression, inhibits cell growth and colony formation in human HepG2 cells, suggesting GCIP plays a significant role in tumor initiation and development."
1029	The expression of p16INK4a tumor suppressor is upregulated by human cytomegalovirus infection and required for optimal viral replication.
10181	3p21.3 tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis.
4771	Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK.
324	The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid.
7157	GAS41 plays a role in repressing the p53 tumor suppressor pathway during the normal cell cycle by a TIP60-independent mechanism.
822	CapG is a new tumor suppressor gene involved in the tumorigenic progression of certain cancers
672	"BRCA1 modulates protein synthesis via its interaction with PABP, providing a novel mechanism by which BRCA1 may exert its tumor suppressor function"
11080	"HLJ1 is a novel tumor suppressor in NSCLC, and high HLJ1 expression is associated with reduced cancer recurrence and prolonged survival of NSCLC patients."
9821	RB1-inducible coiled-coil 1 (RB1CC1) is a novel tumor suppressor implicated in the regulation of RB1 expression.
1490	"CTGF may behave as a secreted tumor suppressor protein in the normal lung, and its expression is suppressed in many NSCLCs."
6196	"RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer."
11186	Isoenzymes may not be tumor suppressor genes but rather stimulates lung cancer cell proliferation.
23705	Involvement of tumor suppressor in lung cancer 1 gene expression in cervical carcinogenesis.
10395	Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors.
90627	Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors.
10641	The 3p21.3 tumor suppressor NPRL2 plays an important role in cisplatin-induced resistance in human non-small-cell lung cancer cells.
91608	RasL10B is a new member of Ras superfamily with tumor suppressor potential
6997	Cripto inhibits the tumor suppressor function of TGF-beta by a novel mechanism.
6876	Transgelin functions as a suppressor to inhibit prostate cancer cell growth
388	"Sudy demonstrates that RhoB expression is frequently downregulated in non-small-cell lung cancer (NSCLC) by multiple mechanisms, suggesting that RhoB is a candidate tumor suppressor gene for NSCLC."
4601	Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma.
7428	"VHL protein exerts its tumor suppressor action, at least partially, via inhibition of p22phox-based Nox4/Nox1 NADPH oxidase-dependent reactive oxygen species generation"
5728	Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions.
7020	data provide evidence that AP-2alpha acts as a tumor suppressor gene in colon cancer
51343	identify a novel mechanism for tumor suppression by TGF-beta and explain why dysfunction of APC in the TGF-beta pathway in responsive cells is associated with cancer.
4830	"NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling."
2272	Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells.

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