Found 463 literature records

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Entrez ID	Description
2131	EXT1 functions as a classical tumor suppressor gene in the cartilage cap of nonhereditary osteochondromas.
6041	RNase L could have a role in cancer biology and evidence of a tumor suppressor function of RNase L has emerged from studies on the genetics of hereditary prostate cancer [review]
7490	Identification of novel Wilms' tumor suppressor gene target genes implicated in kidney development.
11334	Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1.
10253	Spry2 plays a role as tumor suppressor in NSCLC by antagonizing receptor tyrosine kinase-induced signaling at different levels.
8848	The putative tumor suppressor Tsc-22 is downregulated early in chemically induced hepatocarcinogenesis and may be a suppressor of Gadd45b.
5519	These observations identify PP2A Abeta as a tumor suppressor gene that transforms immortalized human cells by regulating the function of RalA.
5524	These observations identify PP2A Abeta as a tumor suppressor gene that transforms immortalized human cells by regulating the function of RalA.
634	data reveal the dual role of CEACAM1 on hepatocarcinogenesis; CEACAM1 acts as tumor suppressor in HepG2 cells in anchorage-depend. growth conditions; in anchorage-independent growth cond it augments cell proliferation by potentiating cell-cell attachment.
5925	"RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, E6, E7, cyclin D1 (CCND1), and c-MYC."
7157	"RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, E6, E7, cyclin D1 (CCND1), and c-MYC."
8848	TSC-22 is a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD
6794	Tumor suppressor LKB1 inhibits activation of signal transducer and activator of transcription 3 (STAT3) by thyroid oncogenic tyrosine kinase rearranged in transformation (RET)/papillary thyroid carcinoma (PTC).
7157	p53 is a direct transcriptional target gene of hPitx1. This observation is concordant with the recent identification of hPitx1 as a tumor suppressor gene.
11009	"MDA-7/IL-24, a novel tumor suppressor/cytokine is ubiquitinated and regulated by the ubiquitin-proteasome system, and inhibition of MDA-7/IL-24 degradation enhances the antitumor activity."
10395	Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells.
50514	"Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma."
10395	DLC-1:a Rho GTPase-activating protein and tumour suppressor.
5728	(PTEN) tumor suppressor gene as a target of MAD1.
9052	"Gprc5a functions as a tumor suppressor in mouse lung, and human GPRC5A may share this property."
317	These data point to a role for Apaf-1 as a bona fide tumor suppressor.
4824	Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1.
7157	interplay between TFIIEalpha and the tumor suppressor protein p53 in regulating transcriptional activation that may be modulated by the phosphorylation status of p53
4763	"Neurofibromatosis type 1 (NF1) tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, CRMP-2."
6794	The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity.
8431	Propose that SHP functions as a novel tumor suppressor in the development of heptaocellular carcinoma.
7157	"Polymorphism Arg72Pro in tumor suppressor gene TP53 increases the risk of lung cancer, especially for small cell lung cancer and heavy smokers."
8650	Data show that the tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila.
27250	mir-21 functions as an oncogene by a mechanism that involves translational repression of the tumor suppressor Pdcd4
115761	A novel tumor suppressor gene [ARLTS1 (ADP-ribosylation factor-like tumor suppressor gene 1)]is found to be altered in human carcinogenesis. It is located in Chromosome 13q14.3.
51343	Study shows a correlation between Skp2 and APC(Cdh1) in breast cancer. Cdh1 may act as an important component in tumor suppression and could be considered as a novel biomarker in breast cancer.
6597	"alterations at BRG1 always occurred in the absence of MYC amplification, suggesting a common role in lung cancer development. In conclusion, our data strongly support that BRG1 is a bona fide tumor suppressor and a major factor in lung tumorigenesis"
6597	This manuscript provides consistent demonstration that inactivating mutations at the SMARCA4 gene are commonly found in lung cancer cell lines. These observations provide evidence that SMARCA4 constitutes a tumor suppressor gene important in lung cancer.
1029	Inactivation of the p19(ARF) tumor suppressor affects intestinal epithelial cell proliferation and integrity.
406947	experiments indicate that miR-155 can act as a tumor suppressor by reducing potentially oncogenic translocations generated by activation-induced cytidine deaminase
1316	Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma.
407040	miR-34a is a tumor suppressor gene in human neuroblastoma
7157	the human glutathione S-transferase P1 gene is a novel transcriptional target of the p53 tumor suppressor gene
8431	Small heterodimer partner plays tumor suppressor function by negatively regulating cellular growth.
1634	Data demonstrate that decorin acts as a tumor suppressor gene and plays an important role in the maintenance of cell maturation and therefore homeostasis in the intestinal tract.
9590	"These findings implicate AKAP12 in the regulation of cytokinesis progression, and suggest a novel role for AKAP12 tumor suppressor."
5371	CK2 mediates phosphorylation and ubiquitin-mediated degradation of the PML tumor suppressor.
26038	"CHD5 is the strongest candidate tumor suppressor gene that is deleted from 1p36.31 in neuroblastomas, and inactivation of the second allele may occur by an epigenetic mechanism."
10950	These data support the hypothesis that BTG3 may act to suppress tumorigenesis and that hypermethylation is an important mechanism for inactivation of BTG3 and perhaps other tumor suppressor genes.
23513	Human T-cell leukemia virus type 1 Tax induces an aberrant clustering of the tumor suppressor Scribble through the PDZ domain-binding motif dependent and independent interaction.
6598	"inhibition of migration is another crucial tumor suppressor function of hSNF5/INI1, in addition to its previously described functions in proliferation and differentiation"
2048	A tumor suppressor role for EPHB2 in rare colorectal cancer cases; rare germline EPHB2 variants may contribute to a small fraction of hereditary colorectal cancer.
5047	Glycodelin-induced differentiation was associated with reduced expression of oncogenes and increased expression of tumor suppressor genes. Our results suggest that glycodelin acts as a tumor suppressor in breast cancer
23705	TSLC1 acts as a candidate tumor suppressor gene for neuroblastoma.
9365	klotho is a potential tumor suppressor and an inhibitor of the IGF-1 pathway and activator of the FGF pathway in human breast cancer

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