Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase

Found 616 literature records

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Entrez IDDescription
5915Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer.
10395DLC1 appears to be a major tumor suppressor genes implicated in the pathogenesis of these tumors
5371A CK2-dependent mechanism for degradation of the PML tumor suppressor.
7157[Rhabdomyosarcoma development in Trp53/fos mutant mice: tumor suppressor functions of the Fos protooncogene].
5268[Role of the class II tumor suppressor gene maspin in thyroid carcinogenesis].
1474Epigenetic silencing of the tumor suppressor cystatin M occurs during breast cancer progression.
863"ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription."
10395Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors.
90627Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors.
23705"TSLC1 inhibits nasopharyngeal carcinoma cell growth by arresting cells in G(0)-G(1) phase in normal culture conditions. Without serum, TSLC1 induced apoptosis. TSLC1 is a tumor suppressor gene in NPC; its loss is seen in lymphatic metastasis."
1630Deleted in colorectal cancer is a putative conditional tumor-suppressor gene inactivated by promoter hypermethylation in head and neck squamous cell carcinoma.
7157"In transfected cells and KSHV-infected B lymphoma cells, KSHV-encoded latency-associated nuclear antigen (LANA) expression stimulates degradation of tumor suppressors von Hippel-Lindau and p53."
7428"In transfected cells and KSHV-infected B lymphoma cells, KSHV-encoded latency-associated nuclear antigen (LANA) expression stimulates degradation of tumor suppressors von Hippel-Lindau and p53."
388"Sudy demonstrates that RhoB expression is frequently downregulated in non-small-cell lung cancer (NSCLC) by multiple mechanisms, suggesting that RhoB is a candidate tumor suppressor gene for NSCLC."
9636"review evidence of a role for ISG15 as an endogenous tumor suppressor that, when dysregulated in malignant cells, can be subverted to promote oncogenesis"
1474Cystatin M may encode a novel epigenetically inactivated candidate tumor suppressor gene.
5728"[Contiguous gene deletion within chromosome arm 10q is associated with juvenile polyposis of infancy, reflecting cooperation between the BMPR1A and PTEN tumor-suppressor genes]."
4601Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma.
84897novel protein with tumor suppressor-like behaviors and functional links to ARF-MDM2-p53 signaling
6273"S100A2 was down-regulated in lymph node metastasis of squamous cell carcinoma, head and neck neoplasms (SCCHN), suggesting that instead of being a putative tumor suppressor, S100A2 may play a role in the metastasis of SCCHN"
4089Inactivation of SMAD4 tumor suppressor gene during gastric carcinoma progression.
55743"CHFR might act as a tumor suppressor in at least some colorectal cancers and that CHFR methylation might, therefore, be a particular phenomenon of early colorectal cancer"
4771NF2-associated GTP binding protein is a tumor suppressor that regulates and requires merlin to suppress cell proliferation
23560NGB is a tumor suppressor that regulates and requires merlin to suppress cell proliferation
1052C/EBPdelta is a novel tumor suppressor gene in acute myeloid leukemia that is silenced by promoter methylation.
1029Persistent hyperplastic primary vitreous due to somatic mosaic deletion of the arf tumor suppressor.
407040MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells.
1316In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma.
2195Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.
22943Dickkopf-1 is an epigenetically silenced candidate tumor suppressor gene in medulloblastoma.
5519Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer.
11197"Thus, WIF1 functions as a tumor suppressor for both NPC and ESCC through suppressing the Wnt-signaling pathway, but is frequently silenced by epigenetic mechanism in a tumor-specific way."
54756Inhibitory effect of hSef on cell proliferation combined with consistent downregulation in human carcinoma indicates a tumor suppressor-like role for Sef.
5789data identify PTPRD as a candidate tumor suppressor gene in cutaneous squamous cell carcinoma with a possible association with metastasis
5728Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.
7980Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma.
56954"Genotype analysis in 4 types of tumor tissue showed allelic imbalance surrounding NIT2 locus; results show that NIT2 plays an important role in cell growth inhibition & links to malignancies, suggesting Nit2 may be a potential tumor suppressor candidate"
9411PARG1 expression was substantially reduced & it displayed at least partial promoter methylation in all investigated mantle-cell lines & in 31 primary cases. PARG1 is a strong candidate tumor suppressor gene in MCL.
8289Genomic and functional evidence for an ARID1A tumor suppressor role.
1316Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastoma.
170692"Functional epigenetics show ADAMTS18 to be a novel functional tumor suppressor, being frequently inactivated epigenetically in multiple carcinomas."
4771The tumor suppressor merlin interacts with microtubules and modulates Schwann cell microtubule cytoskeleton.
5925Results identify BNIP3 as a key regulator of hypoxia-induced autophagy and suggest a novel role for the RB tumor suppressor in preventing nonapoptotic cell death by limiting the extent of BNIP3 induction in cells.
55743CHFR has a role as a tumor suppressor in breast cancer
5925"RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, E6, E7, cyclin D1 (CCND1), and c-MYC."
7157"RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, E6, E7, cyclin D1 (CCND1), and c-MYC."
55294"FBW7 is a novel tumor suppressor in T cell leukemia, and its loss may be a potential mechanism of drug resistance in T-ALL"
1490Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer.
5796"EBNA1 apparently disables TGF-beta signaling, which subsequently decreases transcription of the PTPRK tumor suppressor"
9447The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers.


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