Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
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Found 476 literature records
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Entrez ID
Description
1050
"because C/EBPalpha has been suggested as a potential tumor suppressor in breast cancer, these findings provide important mechanisms whereby 1,25(OH)(2)D(3) may act to inhibit growth of breast cancer cells"
1474
Cystatin M (CST6) tumor suppressor gene is concurrently down-regulated with other loci in breast epithelial cells cocultured with cancer-associated fibroblasts.
9021
SOCS3 is a tumor suppressor in breast cancer cells that is regulated by PRL
7832
Estradiol downregulation of the tumor suppressor gene BTG2 requires estrogen receptor-alpha and the REA corepressor
1029
Methylation status of p16 INK4A tumor suppressor gene in Iranian patients with sporadic breast cancer.
406938
Results support the recent notion that modulating the levels of miR-146a or miR-146b could have a therapeutic potential to suppress breast cancer metastasis.
1029
CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis.
5915
CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis.
672
CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis.
675
CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis.
324
The APC tumor suppressor is required for epithelial integrity in the mouse mammary gland.
2444
Rak functions as a tumor suppressor by regulating PTEN protein stability and function in breast and bone neoplasms.
6794
"Results place LKB1 in a coactivator role for ERalpha signaling, broadening the scientific scope of this tumor suppressor kinase and laying the groundwork for the use of LKB1 as a target for the development of new therapies against breast cancer."
7020
these studies support a tumor suppressor role for AP-2alpha in the gastrointestinal tract
7020
these studies support a tumor suppressor role for AP-2alpha in the gastrointestinal tract.
114826
"Smyd4, as a potential tumor suppressor, plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of Pdgfr-alpha."
5653
KLK6 may play a protective role against tumor progression that is likely mediated by inhibition of epithelial-to-mesenchymal transition. KLK6 may be an epigenetically regulated tumor suppressor in human breast cancer
857
Cav-1 functions as a tumor suppressor in the stromal microenvironment.
2100
ERbeta exerts antiproliferative effects both on MCF-10A and MCF-7 cells in a ligand- and ERalpha-independent manner by regulation of p21/WAF or cyclin A2 gene expression. ERbeta acts as a tumor suppressor in mammary epithelium.
9821
"RB1-inducible coiled-coil 1 (RB1CC1, also known as FIP200) is a tumor suppressor implicated in the regulation of RB1 (retinoblastoma 1) expression."
1029
Results substantiate the critical role of CTCF in establishing and maintaining p16INK4A and other tumor suppressor genes in higher-order chromosomal domains through appropriate boundary formation.
10664
Results substantiate the critical role of CTCF in establishing and maintaining p16INK4A and other tumor suppressor genes in higher-order chromosomal domains through appropriate boundary formation.
10217
High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer.
11186
High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer.
1540
Results suggest that IKKepsilon and CYLD function as an oncogene-tumor suppressor network that participates in tumorigenesis.
3090
"The tumor suppressor HIC1 is implicated in the transcriptional regulation of the chemokine receptor CXCR7, a key player in the promotion of tumorigenesis in a wide variety of cell types."
7157
XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway.
60401
XEDAR is a putative tumor suppressor that could prevent malignant transformation and tumor progression by regulating apoptosis and anoikis.
324
A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis.
4089
A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis.
27250
"Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells."
8821
"INPP4B has been identified as a tumor suppressor. Loss of heterozygosity (LOH) is found at the INPP4B locus in basal-like breast cancers, as well as in a significant fraction of ovarian cancers."
4015
Genetic polymorphism as a mechanism of impaired tumor suppressor function of LOX-propeptide and it may play an etiologic role in ER-negative breast cancer.
9113
Transcriptional activation of the Lats1 tumor suppressor gene in tumors of CUX1 transgenic mice.
3659
Our findings strongly imply a tumor suppressor role for the IRF1 gene in breast cancer.
6794
LKB1 serine-threonine kinase is a tumor suppressor that is inactivated in a large number of sporadic human lung non-small cell carcinomas and cervical cancers.
5371
Germline variants of the promyelocytic leukemia tumor suppressor gene in patients with familial cancer.
406937
"we described a tumor suppression function of miR-145 in breast cancer cell lines, and we linked miR-145 to TP53 and ER-alpha"
23365
LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer
7490
the high frequency of loss of allelic integrity at Wilms' tumor suppressor gene-1 locus in high-graded breast tumors is associated with aggressiveness of the tumor.
57111
Tumor suppressor function of Rab25 in triple-negative breast cancer.
10553
These results demonstrate that promoter methylation is involved in the decreased expression of TIP30 tumor suppressor gene in human colorectal carcinoma.
54971
Tumor suppressor protein SMAR1 modulates the roughness of cell surface: combined AFM and SEM study.
3090
Data report that novel tumor suppressor HIC1 is required for growth suppression by estrogen antagonists in breast cancer cells.
6850
"Syk has a role in limiting proliferation and invasion of epithelial cells during normal morphogenesis, and is a tumor suppressor for breast cancer"
406910
"miR-125a may function as a tumor suppressor for breast cancer, with HuR as a direct and functional target."
1191
"CLU acts as a tumor suppressor in the early stages of carcinogenesis, but CLU may also represent a pro-survival stimulus confering increased resistance to anti-cancer drugs or enhancing tumour cell survival in specific niches. Review."
23541
Fndings raise the possibility that TAP/Sec14L2 may serve as a tumor suppressor in breast carcinogenesis.
23221
A novel tumor suppressor gene RhoBTB2 (DBC2): frequent loss of expression in sporadic breast cancer.
26959
The tumor suppressor protein HBP1 is a novel c-myc-binding protein that negatively regulates c-myc transcriptional activity.
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