SZGR2

Summary ?

GeneID	2534
Symbol	FYN
Synonyms	SLK\|SYN\|p59-FYN
Description	FYN proto-oncogene, Src family tyrosine kinase
Reference	MIM:137025\|HGNC:HGNC:4037\|Ensembl:ENSG00000010810\|HPRD:00655\|Vega:OTTHUMG00000016305
Gene type	protein-coding
Map location	6q21
Pascal p-value	0.009
Sherlock p-value	0.861
Fetal beta	1.145
DMG	1 (# studies)
eGene	Nucleus accumbens basal ganglia
Support	G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Darnell FMRP targets Ascano FMRP targets Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:vanEijk_2014	Genome-wide DNA methylation analysis	This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Expression	Meta-analysis of gene expression	P value: 1.398
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 1.777

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg20985014	6	112374151	FYN	0.003	-5.708		DMG:vanEijk_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
NDRG4	0.86	0.89
TTC7B	0.85	0.86
CLPTM1	0.85	0.83
PLBD2	0.84	0.81
AP001107.1	0.83	0.86
CLSTN3	0.83	0.83
DCTN1	0.82	0.81
PINK1	0.82	0.86
C2CD2L	0.82	0.85
ADAMTSL2	0.82	0.84

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
RBMX2	-0.48	-0.55
FAM159B	-0.48	-0.66
BCL7C	-0.46	-0.57
C21orf57	-0.44	-0.53
RPL31	-0.44	-0.50
RPL35	-0.44	-0.51
RPS20	-0.43	-0.55
C9orf46	-0.43	-0.50
RPL24	-0.43	-0.50
RPL13AP22	-0.43	-0.61

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0005515	protein binding	IEA		-
GO:0005524	ATP binding	IEA		-
GO:0004713	protein tyrosine kinase activity	IEA		-
GO:0004715	non-membrane spanning protein tyrosine kinase activity	NAS		7822789
GO:0016740	transferase activity	IEA		-
GO:0042802	identical protein binding	IPI		14993658
GO:0030145	manganese ion binding	IEA		-
GO:0046872	metal ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0006468	protein amino acid phosphorylation	NAS		7822789
GO:0007243	protein kinase cascade	TAS		1361685
GO:0007631	feeding behavior	TAS		8264796
GO:0007612	learning	TAS		1361685
GO:0006816	calcium ion transport	NAS		7822789
GO:0007275	multicellular organismal development	IEA		-
GO:0050852	T cell receptor signaling pathway	IDA		7722293
GO:0044419	interspecies interaction between organisms	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		10858437
GO:0005768	endosome	IDA		15611048
GO:0005886	plasma membrane	IDA		15611048

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ADAM15	MDC15	ADAM metallopeptidase domain 15	-	HPRD,BioGRID	11741929
ADD2	ADDB	adducin 2 (beta)	-	HPRD,BioGRID	11526103
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	-	HPRD,BioGRID	9188452
BCL3	BCL4 \| D19S37	B-cell CLL/lymphoma 3	-	HPRD,BioGRID	9576921
BTK	AGMX1 \| AT \| ATK \| BPK \| IMD1 \| MGC126261 \| MGC126262 \| PSCTK1 \| XLA	Bruton agammaglobulinemia tyrosine kinase	Reconstituted Complex	BioGRID	8058772
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	-	HPRD,BioGRID	9535867
CBLC	CBL-3 \| CBL-SL \| RNF57	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	Affinity Capture-Western Reconstituted Complex	BioGRID	10571044
CD19	B4 \| MGC12802	CD19 molecule	-	HPRD	7589101
CD2	SRBC \| T11	CD2 molecule	-	HPRD,BioGRID	9677430
CD226	DNAM-1 \| DNAM1 \| PTA1 \| TLiSA1	CD226 molecule	-	HPRD,BioGRID	10591186
CD2AP	CMS \| DKFZp586H0519	CD2-associated protein	-	HPRD	10339567
CD36	CHDS7 \| FAT \| GP3B \| GP4 \| GPIV \| PASIV \| SCARB3	CD36 molecule (thrombospondin receptor)	-	HPRD,BioGRID	7521304
CD44	CDW44 \| CSPG8 \| ECMR-III \| HCELL \| IN \| LHR \| MC56 \| MDU2 \| MDU3 \| MGC10468 \| MIC4 \| MUTCH-I \| Pgp1	CD44 molecule (Indian blood group)	-	HPRD,BioGRID	9573028
CD48	BCM1 \| BLAST \| BLAST1 \| MEM-102 \| SLAMF2 \| hCD48 \| mCD48	CD48 molecule	-	HPRD	8104794
CD55	CR \| CROM \| DAF \| TC	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	-	HPRD	1385527
CDC2	CDC28A \| CDK1 \| DKFZp686L20222 \| MGC111195	cell division cycle 2, G1 to S and G2 to M	-	HPRD,BioGRID	8910336
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	Affinity Capture-Western Reconstituted Complex	BioGRID	12640114
CHRNA7	CHRNA7-2 \| NACHRA7	cholinergic receptor, nicotinic, alpha 7	Affinity Capture-Western	BioGRID	11278378
CNTN1	F3 \| GP135	contactin 1	-	HPRD,BioGRID	7595520
CSF1R	C-FMS \| CD115 \| CSFR \| FIM2 \| FMS	colony stimulating factor 1 receptor	-	HPRD,BioGRID	7681396
CSK	MGC117393	c-src tyrosine kinase	-	HPRD,BioGRID	8262983
CTLA4	CD152 \| CELIAC3 \| CTLA-4 \| GSE \| IDDM12	cytotoxic T-lymphocyte-associated protein 4	-	HPRD,BioGRID	9712716
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	Biochemical Activity	BioGRID	12640114
CTNND1	CAS \| CTNND \| KIAA0384 \| P120CAS \| P120CTN \| p120	catenin (cadherin-associated protein), delta 1	Affinity Capture-Western Biochemical Activity	BioGRID	12640114 \|12835311
CTNND2	GT24 \| NPRAP	catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)	-	HPRD	12835311
DAG1	156DAG \| A3a \| AGRNR \| DAG	dystroglycan 1 (dystrophin-associated glycoprotein 1)	Affinity Capture-Western Reconstituted Complex	BioGRID	11724572
DCC	CRC18 \| CRCR1	deleted in colorectal carcinoma	DCC interacts with Fyn.	BIND	15494732
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	-	HPRD,BioGRID	12419528
DOK3	DOKL \| FLJ22570 \| FLJ39939	docking protein 3	-	HPRD	10733577
DOK4	FLJ10488	docking protein 4	IRS5/DOK4 interacts with Fyn. This interaction was modelled on a demonstrated interaction between human IRS5/DOK4 and hamster Fyn.	BIND	12730241
DOK4	FLJ10488	docking protein 4	-	HPRD	12730241
EPHA4	HEK8 \| SEK \| TYRO1	EPH receptor A4	-	HPRD,BioGRID	12084815
EPHA8	EEK \| HEK3 \| KIAA1459	EPH receptor A8	-	HPRD,BioGRID	10498895
EPHB3	ETK2 \| HEK2 \| TYRO6	EPH receptor B3	-	HPRD,BioGRID	9674711
EVL	RNB6	Enah/Vasp-like	-	HPRD	10945997
FAS	ALPS1A \| APO-1 \| APT1 \| CD95 \| FAS1 \| FASTM \| TNFRSF6	Fas (TNF receptor superfamily, member 6)	-	HPRD,BioGRID	8626376
FASLG	APT1LG1 \| CD178 \| CD95L \| FASL \| TNFSF6	Fas ligand (TNF superfamily, member 6)	-	HPRD,BioGRID	7589480
FNBP4	DKFZp686M14102 \| DKFZp779I1064 \| FBP30 \| FLJ41904 \| KIAA1014	formin binding protein 4	-	HPRD,BioGRID	10744724
FYB	ADAP \| PRO0823 \| SLAP-130	FYN binding protein (FYB-120/130)	-	HPRD	7504057 \|9207119
FYB	ADAP \| PRO0823 \| SLAP-130	FYN binding protein (FYB-120/130)	-	HPRD,BioGRID	7504057
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	-	HPRD,BioGRID	7687536
GAB3	-	GRB2-associated binding protein 3	-	HPRD,BioGRID	11739737
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	-	HPRD,BioGRID	11943848 \|12524444
GP6	GPIV \| GPVI \| MGC138168	glycoprotein VI (platelet)	-	HPRD,BioGRID	11943772
GRB10	GRB-IR \| Grb-10 \| IRBP \| KIAA0207 \| MEG1 \| RSS	growth factor receptor-bound protein 10	-	HPRD,BioGRID	10871840
GRIN2A	NMDAR2A \| NR2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	Affinity Capture-Western Reconstituted Complex	BioGRID	9892651 \|10458595 \|12419528 \|12932824
GRIN2A	NMDAR2A \| NR2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	-	HPRD	10458595 \|12932824
GRIN2B	MGC142178 \| MGC142180 \| NMDAR2B \| NR2B \| hNR3	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	-	HPRD,BioGRID	10458595
HNRNPK	CSBP \| FLJ41122 \| HNRPK \| TUNP	heterogeneous nuclear ribonucleoprotein K	Fyn interacts with hnRNPK. This interaction was modeled on a demonstrated interaction between Fyn from an unspecified source and human hnRNPK.	BIND	8810341
IL7R	CD127 \| CDW127 \| IL-7R-alpha \| IL7RA \| ILRA	interleukin 7 receptor	-	HPRD,BioGRID	7515933
ITK	EMT \| LYK \| MGC126257 \| MGC126258 \| PSCTK2	IL2-inducible T-cell kinase	-	HPRD,BioGRID	8810341
JAK2	JTK10	Janus kinase 2 (a protein tyrosine kinase)	-	HPRD,BioGRID	10551884
KHDRBS1	FLJ34027 \| Sam68 \| p62	KH domain containing, RNA binding, signal transduction associated 1	-	HPRD,BioGRID	9045636
MAG	GMA \| S-MAG \| SIGLEC-4A \| SIGLEC4A	myelin associated glycoprotein	-	HPRD,BioGRID	7525550
MAP2	DKFZp686I2148 \| MAP2A \| MAP2B \| MAP2C	microtubule-associated protein 2	Affinity Capture-Western	BioGRID	11546790
MAPT	DDPAC \| FLJ31424 \| FTDP-17 \| MAPTL \| MGC138549 \| MSTD \| MTBT1 \| MTBT2 \| PPND \| TAU	microtubule-associated protein tau	-	HPRD,BioGRID	11826099
MCAM	CD146 \| MUC18	melanoma cell adhesion molecule	-	HPRD,BioGRID	9756930
MS4A1	B1 \| Bp35 \| CD20 \| LEU-16 \| MGC3969 \| MS4A2 \| S7	membrane-spanning 4-domains, subfamily A, member 1	-	HPRD,BioGRID	7545683
NCAM1	CD56 \| MSK39 \| NCAM	neural cell adhesion molecule 1	-	HPRD	9079653 \|11839780
NEDD9	CAS-L \| CAS2 \| CASL \| CASS2 \| HEF1 \| dJ49G10.2 \| dJ761I2.1	neural precursor cell expressed, developmentally down-regulated 9	-	HPRD,BioGRID	9360983
NMT1	NMT	N-myristoyltransferase 1	Biochemical Activity	BioGRID	11594778
NPHS1	CNF \| NPHN	nephrosis 1, congenital, Finnish type (nephrin)	-	HPRD,BioGRID	12668668 \|12846735
NTRK2	GP145-TrkB \| TRKB	neurotrophic tyrosine kinase, receptor, type 2	-	HPRD,BioGRID	9648856
PAG1	CBP \| FLJ37858 \| MGC138364 \| PAG	phosphoprotein associated with glycosphingolipid microdomains 1	-	HPRD,BioGRID	10790433
PDE4D	DPDE3 \| HSPDE4D \| PDE4DN2 \| STRK1	phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)	PDE4D4 interacts with Fyn SH3 domain.	BIND	10571082
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	-	HPRD	1696179
PECAM1	CD31 \| PECAM-1	platelet/endothelial cell adhesion molecule	-	HPRD,BioGRID	10858437
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD	8394019
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	Reconstituted Complex	BioGRID	8294442
PIK3R2	P85B \| p85 \| p85-BETA	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	-	HPRD,BioGRID	1334406
PLAUR	CD87 \| UPAR \| URKR	plasminogen activator, urokinase receptor	-	HPRD	9417082
PLCG1	PLC-II \| PLC1 \| PLC148 \| PLCgamma1	phospholipase C, gamma 1	-	HPRD	10586033
PLCG2	-	phospholipase C, gamma 2 (phosphatidylinositol-specific)	-	HPRD,BioGRID	8395016
PLD2	-	phospholipase D2	-	HPRD	12697812
PRKCQ	MGC126514 \| MGC141919 \| PRKCT \| nPKC-theta	protein kinase C, theta	-	HPRD,BioGRID	10383400
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	-	HPRD,BioGRID	11278857
PTK2B	CADTK \| CAKB \| FADK2 \| FAK2 \| FRNK \| PKB \| PTK \| PYK2 \| RAFTK	PTK2B protein tyrosine kinase 2 beta	-	HPRD,BioGRID	9091579 \|9104812 \|10867021
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	-	HPRD,BioGRID	10212213
PTPN5	FLJ14427 \| PTPSTEP \| STEP	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	-	HPRD,BioGRID	11983687
PTPRA	HEPTP \| HLPR \| HPTPA \| HPTPalpha \| LRP \| PTPA \| PTPRL2 \| R-PTP-alpha \| RPTPA	protein tyrosine phosphatase, receptor type, A	-	HPRD,BioGRID	9535845
PTPRC	B220 \| CD45 \| CD45R \| GP180 \| LCA \| LY5 \| T200	protein tyrosine phosphatase, receptor type, C	-	HPRD	9368621 \|12589038
PXN	FLJ16691	paxillin	-	HPRD,BioGRID	10804218
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	-	HPRD,BioGRID	7517401
RICS	GC-GAP \| GRIT \| KIAA0712 \| MGC1892 \| p200RhoGAP \| p250GAP	Rho GTPase-activating protein	-	HPRD,BioGRID	12788081 \|12857875
RPL10	DKFZp686J1851 \| DXS648 \| DXS648E \| FLJ23544 \| FLJ27072 \| NOV \| QM	ribosomal protein L10	Reconstituted Complex	BioGRID	12138090
SDC3	N-syndecan \| SDCN \| SYND3	syndecan 3	-	HPRD,BioGRID	9553134
SH2B2	APS	SH2B adaptor protein 2	-	HPRD	10872802
SH2D1A	DSHP \| EBVS \| FLJ18687 \| FLJ92177 \| IMD5 \| LYP \| MTCP1 \| SAP \| XLP \| XLPD	SH2 domain protein 1A	-	HPRD,BioGRID	12545174
SH3BP2	3BP2 \| CRBM \| CRPM \| FLJ42079 \| RES4-23	SH3-domain binding protein 2	Two-hybrid	BioGRID	9846481
SIT1	MGC125908 \| MGC125909 \| MGC125910 \| RP11-331F9.5 \| SIT	signaling threshold regulating transmembrane adaptor 1	-	HPRD,BioGRID	10209036
SKAP1	SCAP1 \| SKAP55	src kinase associated phosphoprotein 1	-	HPRD,BioGRID	9195899
SKAP2	MGC10411 \| MGC33304 \| PRAP \| RA70 \| SAPS \| SCAP2 \| SKAP-HOM \| SKAP55R	src kinase associated phosphoprotein 2	-	HPRD,BioGRID	9837776
SLAMF1	CD150 \| CDw150 \| SLAM	signaling lymphocytic activation molecule family member 1	Reconstituted Complex	BioGRID	12545174
SNCA	MGC110988 \| NACP \| PARK1 \| PARK4 \| PD1	synuclein, alpha (non A4 component of amyloid precursor)	-	HPRD,BioGRID	11162638
SOCS1	CIS1 \| CISH1 \| JAB \| SOCS-1 \| SSI-1 \| SSI1 \| TIP3	suppressor of cytokine signaling 1	Socs1 interacts with Fyn. This interaction was modeled on a demonstrated interaction between mouse Socs1 and Fyn from an unspecified species.	BIND	10022833
SOCS1	CIS1 \| CISH1 \| JAB \| SOCS-1 \| SSI-1 \| SSI1 \| TIP3	suppressor of cytokine signaling 1	-	HPRD,BioGRID	10022833
SOS1	GF1 \| GGF1 \| GINGF \| HGF \| NS4	son of sevenless homolog 1 (Drosophila)	-	HPRD,BioGRID	9856337
SPN	CD43 \| GPL115 \| LSN	sialophorin	-	HPRD	9603925
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Protein-peptide	BioGRID	9169421
SYK	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	-	HPRD,BioGRID	9535867
THY1	CD90 \| FLJ33325	Thy-1 cell surface antigen	-	HPRD,BioGRID	1351058
TNK2	ACK \| ACK1 \| FLJ44758 \| FLJ45547 \| p21cdc42Hs	tyrosine kinase, non-receptor, 2	-	HPRD,BioGRID	11087735
TOM1L1	OK/KNS-CL.3 \| SRCASM	target of myb1 (chicken)-like 1	Reconstituted Complex	BioGRID	11711534
TRAT1	HSPC062 \| TCRIM \| TRIM	T cell receptor associated transmembrane adaptor 1	Reconstituted Complex	BioGRID	10790433
TRPC6	FLJ11098 \| FLJ14863 \| FSGS2 \| TRP6	transient receptor potential cation channel, subfamily C, member 6	-	HPRD,BioGRID	14761972
TRPV4	OTRPC4 \| TRP12 \| VR-OAC \| VRL-2 \| VRL2 \| VROAC	transient receptor potential cation channel, subfamily V, member 4	-	HPRD,BioGRID	12538589
TUBA1B	K-ALPHA-1	tubulin, alpha 1b	-	HPRD	11826099
TUBA3C	TUBA2 \| bA408E5.3	tubulin, alpha 3c	-	HPRD,BioGRID	8566014 \|11826099
TUBA4A	FLJ30169 \| H2-ALPHA \| TUBA1	tubulin, alpha 4a	-	HPRD	8566014
TYK2	JTK1	tyrosine kinase 2	-	HPRD,BioGRID	9196040
TYRO3	BYK \| Brt \| Dtk \| FLJ16467 \| RSE \| Sky \| Tif	TYRO3 protein tyrosine kinase	-	HPRD	7537495
UNC119	HRG4	unc-119 homolog (C. elegans)	-	HPRD,BioGRID	14757743
VAV1	VAV	vav 1 guanine nucleotide exchange factor	-	HPRD,BioGRID	9822663
WAS	IMD2 \| THC \| WASP	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	Affinity Capture-Western Reconstituted Complex	BioGRID	8805332 \|10532312
WAS	IMD2 \| THC \| WASP	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	-	HPRD	8805332 \|10224664 \|10532312
WASF1	FLJ31482 \| KIAA0269 \| SCAR1 \| WAVE \| WAVE1	WAS protein family, member 1	-	HPRD	10532312
WASF2	SCAR2 \| WAVE2 \| dJ393P12.2	WAS protein family, member 2	-	HPRD	10532312
YES1	HsT441 \| P61-YES \| Yes \| c-yes	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	Affinity Capture-Western	BioGRID	12640114
YTHDC1	KIAA1966 \| YT521 \| YT521-B	YTH domain containing 1	-	HPRD,BioGRID	15175272
ZAP70	FLJ17670 \| FLJ17679 \| SRK \| STD \| TZK \| ZAP-70	zeta-chain (TCR) associated protein kinase 70kDa	-	HPRD,BioGRID	7760813

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG AXON GUIDANCE	129	103	All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION	75	53	All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY	137	92	All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY	108	89	All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY	79	58	All SZGR 2.0 genes in this pathway
KEGG PRION DISEASES	35	28	All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION	59	36	All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS	73	58	All SZGR 2.0 genes in this pathway
BIOCARTA BIOPEPTIDES PATHWAY	45	35	All SZGR 2.0 genes in this pathway
BIOCARTA EPHA4 PATHWAY	10	8	All SZGR 2.0 genes in this pathway
BIOCARTA ECM PATHWAY	24	17	All SZGR 2.0 genes in this pathway
BIOCARTA IL7 PATHWAY	17	14	All SZGR 2.0 genes in this pathway
BIOCARTA INTEGRIN PATHWAY	38	29	All SZGR 2.0 genes in this pathway
BIOCARTA TCRA PATHWAY	13	10	All SZGR 2.0 genes in this pathway
BIOCARTA TCR PATHWAY	49	37	All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY	82	62	All SZGR 2.0 genes in this pathway
PID FCER1 PATHWAY	62	43	All SZGR 2.0 genes in this pathway
PID ERBB4 PATHWAY	38	32	All SZGR 2.0 genes in this pathway
PID GLYPICAN 1PATHWAY	27	20	All SZGR 2.0 genes in this pathway
PID TCR PATHWAY	66	51	All SZGR 2.0 genes in this pathway
PID PTP1B PATHWAY	52	40	All SZGR 2.0 genes in this pathway
PID REELIN PATHWAY	29	29	All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY	31	25	All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY	53	42	All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY	50	41	All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY	57	43	All SZGR 2.0 genes in this pathway
PID NETRIN PATHWAY	32	27	All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY	55	43	All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY	102	78	All SZGR 2.0 genes in this pathway
PID PI3KCI PATHWAY	49	40	All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY	48	38	All SZGR 2.0 genes in this pathway
PID AMB2 NEUTROPHILS PATHWAY	41	32	All SZGR 2.0 genes in this pathway
PID EPHA FWDPATHWAY	34	29	All SZGR 2.0 genes in this pathway
PID ECADHERIN KERATINOCYTE PATHWAY	21	19	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID NEPHRIN NEPH1 PATHWAY	31	24	All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY	69	57	All SZGR 2.0 genes in this pathway
PID SYNDECAN 3 PATHWAY	17	15	All SZGR 2.0 genes in this pathway
PID EPHRINB REV PATHWAY	30	25	All SZGR 2.0 genes in this pathway
PID ALPHA SYNUCLEIN PATHWAY	33	25	All SZGR 2.0 genes in this pathway
PID FAK PATHWAY	59	45	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT	78	59	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION	120	77	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF KIT SIGNALING	17	10	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	29	24	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	126	90	All SZGR 2.0 genes in this pathway
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	91	65	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	12	8	All SZGR 2.0 genes in this pathway
REACTOME PECAM1 INTERACTIONS	10	7	All SZGR 2.0 genes in this pathway
REACTOME GPVI MEDIATED ACTIVATION CASCADE	31	25	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	64	49	All SZGR 2.0 genes in this pathway
REACTOME CD28 CO STIMULATION	32	26	All SZGR 2.0 genes in this pathway
REACTOME CRMPS IN SEMA3A SIGNALING	14	14	All SZGR 2.0 genes in this pathway
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	15	14	All SZGR 2.0 genes in this pathway
REACTOME CD28 DEPENDENT VAV1 PATHWAY	11	10	All SZGR 2.0 genes in this pathway
REACTOME SEMAPHORIN INTERACTIONS	68	53	All SZGR 2.0 genes in this pathway
REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	13	9	All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY	63	48	All SZGR 2.0 genes in this pathway
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	22	18	All SZGR 2.0 genes in this pathway
REACTOME CTLA4 INHIBITORY SIGNALING	21	15	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS	107	86	All SZGR 2.0 genes in this pathway
REACTOME NETRIN1 SIGNALING	41	30	All SZGR 2.0 genes in this pathway
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	13	11	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF SIGNALING BY CBL	18	16	All SZGR 2.0 genes in this pathway
REACTOME NEPHRIN INTERACTIONS	20	15	All SZGR 2.0 genes in this pathway
REACTOME IL 3 5 AND GM CSF SIGNALING	43	34	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION	207	122	All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS	132	81	All SZGR 2.0 genes in this pathway
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	28	19	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN	481	290	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN	526	357	All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP	351	230	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP	473	314	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN	320	184	All SZGR 2.0 genes in this pathway
LIU VMYB TARGETS UP	127	78	All SZGR 2.0 genes in this pathway
RODRIGUES DCC TARGETS DN	121	84	All SZGR 2.0 genes in this pathway
BILBAN B CLL LPL DN	42	25	All SZGR 2.0 genes in this pathway
AKL HTLV1 INFECTION DN	68	41	All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA UP	171	112	All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA BY DMOG UP	130	85	All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A TARGETS DN	91	58	All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A AND HIF2A TARGETS DN	104	72	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS UP	149	84	All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS UP	194	112	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN	508	354	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP	443	294	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN	378	231	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS	1174	695	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B	392	251	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER HIGH RECURRENCE	49	31	All SZGR 2.0 genes in this pathway
LUI THYROID CANCER CLUSTER 1	51	33	All SZGR 2.0 genes in this pathway
XU HGF SIGNALING NOT VIA AKT1 48HR UP	35	20	All SZGR 2.0 genes in this pathway
WANG METHYLATED IN BREAST CANCER	35	25	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN	164	111	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP	358	245	All SZGR 2.0 genes in this pathway
WU CELL MIGRATION	184	114	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
DING LUNG CANCER MUTATED FREQUENTLY	12	10	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 UP	45	29	All SZGR 2.0 genes in this pathway
NADLER HYPERGLYCEMIA AT OBESITY	58	35	All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION	405	264	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP	390	242	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP	262	186	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR DN	178	121	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN	318	220	All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN WITHOUT MGMT 48HR DN	32	25	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C3	36	24	All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6	153	112	All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN	161	105	All SZGR 2.0 genes in this pathway
SAFFORD T LYMPHOCYTE ANERGY	87	54	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D8	40	29	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN	271	175	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR DN	101	64	All SZGR 2.0 genes in this pathway
KRIGE AMINO ACID DEPRIVATION	29	20	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP	783	442	All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3	491	310	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP	299	167	All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN	940	425	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN	315	197	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN	564	326	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP	476	285	All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING	246	152	All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP	147	98	All SZGR 2.0 genes in this pathway
LU TUMOR ANGIOGENESIS UP	25	22	All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION	175	125	All SZGR 2.0 genes in this pathway
JIANG TIP30 TARGETS UP	46	28	All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE	346	192	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN	315	201	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN	235	144	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP	408	276	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN	435	289	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN	442	275	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 11	36	24	All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN	181	97	All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G123 DN	51	30	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS EARLY UP	66	44	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 M	216	124	All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP	242	159	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP	259	159	All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN	321	200	All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN	448	282	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
ALFANO MYC TARGETS	239	156	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-27	186	192	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	186	192	1A	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-369-3p	387	393	m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-96	295	301	m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: FYN