Gene Page: CASP2
Summary ?
| GeneID | 835 |
| Symbol | CASP2 |
| Synonyms | CASP-2|ICH1|NEDD-2|NEDD2|PPP1R57 |
| Description | caspase 2 |
| Reference | MIM:600639|HGNC:HGNC:1503|Ensembl:ENSG00000106144|HPRD:02800|Vega:OTTHUMG00000023641 |
| Gene type | protein-coding |
| Map location | 7q34-q35 |
| Pascal p-value | 0.006 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NUP107 | 0.88 | 0.81 |
| PPP4R1 | 0.86 | 0.84 |
| ZNF3 | 0.86 | 0.78 |
| NVL | 0.86 | 0.80 |
| TRIP13 | 0.86 | 0.80 |
| EZH2 | 0.85 | 0.81 |
| NUP205 | 0.85 | 0.77 |
| E2F5 | 0.85 | 0.81 |
| SUV39H2 | 0.85 | 0.79 |
| CREB3L4 | 0.85 | 0.75 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FBXO2 | -0.66 | -0.73 |
| HLA-F | -0.65 | -0.72 |
| AIFM3 | -0.63 | -0.69 |
| C5orf53 | -0.62 | -0.69 |
| CA4 | -0.62 | -0.72 |
| ALDOC | -0.61 | -0.66 |
| PTH1R | -0.61 | -0.66 |
| ASPHD1 | -0.61 | -0.64 |
| LDHD | -0.61 | -0.65 |
| AF347015.27 | -0.60 | -0.74 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| BCL2 | Bcl-2 | B-cell CLL/lymphoma 2 | Phenotypic Suppression | BioGRID | 11832478 |
| BCL2L1 | BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xS | BCL2-like 1 | Phenotypic Suppression | BioGRID | 11832478 |
| BID | FP497 | MGC15319 | MGC42355 | BH3 interacting domain death agonist | - | HPRD,BioGRID | 11832478 |
| CASP10 | ALPS2 | FLICE2 | MCH4 | caspase 10, apoptosis-related cysteine peptidase | - | HPRD,BioGRID | 8962078 |
| CASP14 | MGC119078 | MGC119079 | caspase 14, apoptosis-related cysteine peptidase | - | HPRD,BioGRID | 9792675 |
| CASP2 | CASP-2 | ICH-1L | ICH-1L/1S | ICH1 | NEDD2 | caspase 2, apoptosis-related cysteine peptidase | Biochemical Activity | BioGRID | 11832478 |
| CASP3 | CPP32 | CPP32B | SCA-1 | caspase 3, apoptosis-related cysteine peptidase | Biochemical Activity | BioGRID | 11399776 |
| CASP7 | CMH-1 | ICE-LAP3 | MCH3 | caspase 7, apoptosis-related cysteine peptidase | - | HPRD,BioGRID | 11399776 |
| CASP8 | ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473 | caspase 8, apoptosis-related cysteine peptidase | Biochemical Activity | BioGRID | 8962078 |11832478 |
| CASP9 | APAF-3 | APAF3 | CASPASE-9c | ICE-LAP6 | MCH6 | caspase 9, apoptosis-related cysteine peptidase | Phenotypic Suppression | BioGRID | 11832478 |
| CCND3 | - | cyclin D3 | - | HPRD,BioGRID | 12011445 |
| CRADD | MGC9163 | RAIDD | CASP2 and RIPK1 domain containing adaptor with death domain | The CARD domain of Casp2 interacts with the death domain (DD) of RAIDD. | BIND | 15073321 |
| CRADD | MGC9163 | RAIDD | CASP2 and RIPK1 domain containing adaptor with death domain | - | HPRD | 8985253 |9695946 |11156409 |11832478 |15073321 |
| CRADD | MGC9163 | RAIDD | CASP2 and RIPK1 domain containing adaptor with death domain | Affinity Capture-Western Phenotypic Suppression Reconstituted Complex Two-hybrid | BioGRID | 8985253 |11156409 |15073321 |
| DCTN1 | DAP-150 | DP-150 | HMN7B | P135 | dynactin 1 (p150, glued homolog, Drosophila) | - | HPRD | 11425872 |
| DSP | DPI | DPII | desmoplakin | - | HPRD | 15500642 |
| GOLGA3 | GCP170 | MEA-2 | golgi autoantigen, golgin subfamily a, 3 | - | HPRD | 10791974 |
| HTT | HD | IT15 | huntingtin | Htt interacts with caspase 2. | BIND | 14713958 |
| KPNA2 | IPOA1 | QIP2 | RCH1 | SRP1alpha | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | - | HPRD | 12477715 |
| LRDD | DKFZp434D229 | MGC16925 | PIDD | leucine-rich repeats and death domain containing | - | HPRD,BioGRID | 15073321 |
| NLRP1 | CARD7 | CLR17.1 | DEFCAP | DEFCAP-L/S | DKFZp586O1822 | KIAA0926 | NAC | NALP1 | PP1044 | SLEV1 | VAMAS1 | NLR family, pyrin domain containing 1 | - | HPRD,BioGRID | 11076957 |
| NOD1 | CARD4 | CLR7.1 | NLRC1 | nucleotide-binding oligomerization domain containing 1 | - | HPRD,BioGRID | 10329646 |
| NOL3 | ARC | CARD2 | MYC | MYP | NOP | NOP30 | nucleolar protein 3 (apoptosis repressor with CARD domain) | - | HPRD,BioGRID | 9560245 |
| RB1 | OSRC | RB | p105-Rb | pRb | pp110 | retinoblastoma 1 | CASP2 (caspase-2) cleaves RB-1 (hRB) at the DEAD consensus site into the p100 form. | BIND | 15735701 |
| TNFRSF1A | CD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60 | tumor necrosis factor receptor superfamily, member 1A | Affinity Capture-Western | BioGRID | 8985253 |
| XIAP | API3 | BIRC4 | ILP1 | MIHA | XLP2 | X-linked inhibitor of apoptosis | Phenotypic Suppression | BioGRID | 11832478 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BIOCARTA CASPASE PATHWAY | 23 | 15 | All SZGR 2.0 genes in this pathway |
| BIOCARTA HIVNEF PATHWAY | 58 | 43 | All SZGR 2.0 genes in this pathway |
| BIOCARTA STRESS PATHWAY | 25 | 18 | All SZGR 2.0 genes in this pathway |
| BIOCARTA TNFR1 PATHWAY | 29 | 21 | All SZGR 2.0 genes in this pathway |
| PID P73PATHWAY | 79 | 59 | All SZGR 2.0 genes in this pathway |
| PID HIV NEF PATHWAY | 35 | 26 | All SZGR 2.0 genes in this pathway |
| PID CASPASE PATHWAY | 52 | 39 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALLING BY NGF | 217 | 167 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | 60 | 43 | All SZGR 2.0 genes in this pathway |
| REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | 81 | 61 | All SZGR 2.0 genes in this pathway |
| REACTOME INNATE IMMUNE SYSTEM | 279 | 178 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME NOD1 2 SIGNALING PATHWAY | 30 | 22 | All SZGR 2.0 genes in this pathway |
| REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS | 46 | 33 | All SZGR 2.0 genes in this pathway |
| WATANABE COLON CANCER MSI VS MSS UP | 29 | 18 | All SZGR 2.0 genes in this pathway |
| FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP | 579 | 346 | All SZGR 2.0 genes in this pathway |
| OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN | 275 | 168 | All SZGR 2.0 genes in this pathway |
| LAU APOPTOSIS CDKN2A UP | 55 | 40 | All SZGR 2.0 genes in this pathway |
| MARKEY RB1 CHRONIC LOF UP | 115 | 78 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| NUNODA RESPONSE TO DASATINIB IMATINIB DN | 13 | 10 | All SZGR 2.0 genes in this pathway |
| BAKER HEMATOPOESIS STAT1 TARGETS | 10 | 9 | All SZGR 2.0 genes in this pathway |
| GALLUZZI PERMEABILIZE MITOCHONDRIA | 43 | 31 | All SZGR 2.0 genes in this pathway |
| RASHI RESPONSE TO IONIZING RADIATION 4 | 61 | 34 | All SZGR 2.0 genes in this pathway |
| PATIL LIVER CANCER | 747 | 453 | All SZGR 2.0 genes in this pathway |
| MOHANKUMAR TLX1 TARGETS UP | 414 | 287 | All SZGR 2.0 genes in this pathway |
| PUJANA XPRSS INT NETWORK | 168 | 103 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA2 PCC NETWORK | 423 | 265 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| WEI MIR34A TARGETS | 148 | 97 | All SZGR 2.0 genes in this pathway |
| GARCIA TARGETS OF FLI1 AND DAX1 DN | 176 | 104 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 18HR UP | 178 | 111 | All SZGR 2.0 genes in this pathway |
| TSENG IRS1 TARGETS DN | 135 | 88 | All SZGR 2.0 genes in this pathway |
| BILD HRAS ONCOGENIC SIGNATURE | 261 | 166 | All SZGR 2.0 genes in this pathway |
| FUJII YBX1 TARGETS DN | 202 | 132 | All SZGR 2.0 genes in this pathway |
| MOOTHA MITOCHONDRIA | 447 | 277 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| WHITFIELD CELL CYCLE G1 S | 147 | 76 | All SZGR 2.0 genes in this pathway |
| WHITFIELD CELL CYCLE S | 162 | 86 | All SZGR 2.0 genes in this pathway |
| LU EZH2 TARGETS DN | 414 | 237 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 3 UP | 170 | 97 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 4 UP | 112 | 64 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 6 UP | 140 | 81 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 7 UP | 118 | 68 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 DN | 918 | 550 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP B | 549 | 316 | All SZGR 2.0 genes in this pathway |