Found 134 literature records

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Entrez ID	Description
7462	NTAL acts as a tumor suppressor that enhances the proximal signaling of leukemic blasts. The key downstream molecule responsible for the biological effect of TCR signaling is ERK.
2322	excessive Flt3 expression has growth-suppressive properties in several human cancer cell lines
5788	A tumor suppressor role for CD45 in T-cell acute lymphoblastic leukemia.
442915	"miR-370 may function as a tumor suppressor by targeting FoxM1, and the epigenetic silence of miR-370 thus leads to derepression of FoxM1 expression and consequently contributes to AML development and progression."
29760	Tumor suppressor BLNK is a target of transcriptional activation by PU.1 and Spi-B in the B cell lineage.
574453	miR-495 likely functions as a tumor suppressor in acute myeloid leukemia with MLL rearrangements.
3065	A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.
51523	Lack of promoter hypermethylation or somatic mutations are found in the potential tumor suppressor CXXC5 in myelodysplastic syndromes or acute myeloid leukemia with deletion 5q.
1523	"Data indicate CUX1 as a conserved, haploinsufficient tumor suppressor frequently deleted in myeloid neoplasms."
407018	These data indicate that miR-27a contributes a tumor suppressor-like activity in acute leukemia cells via regulation of apoptosis
4849	"CNOT3 is a tumor suppressor mutated in 7 of 89 (7.9%) adult T-cell acute lymphoblastic leukemias, and its knockdown causes tumors in a sensitized Drosophila melanogaster model."
57167	The mechanism of SALL4 in promoting leukemogenesis is at least in part mediated by its repression of the tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) through its interaction with a histone deacetylase (HDAC) complex.
10010	"This study characterized the novel gene tank, a tumor suppressor homolog that promotes ethanol sensitivity in Drosophila"
406917	MiR-129 has a unique potential as a tumor suppressor and a novel candidate for developing miR-129-based therapeutic strategies in colorectal cancer.
406918	MiR-129 has a unique potential as a tumor suppressor and a novel candidate for developing miR-129-based therapeutic strategies in colorectal cancer.
127700	"Data revealed novel aspects of the interplay between autophagy and apoptosis in nasopharyngeal carcinoma cells, which underlies the tumor suppression function of NOR1."
55294	The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia.
10019	"Overall, these results demonstrate a Knudson tumor suppressor role for SH2B3 in the pathogenesis of acute lymphoblastic leukemia"
2146	"PRC2 is a tumor suppressor in Emicro-myc lymphomagenesis, because disease onset was accelerated by heterozygosity for Suz12 or by short hairpin RNA-mediated knockdown of Suz12 or Ezh2."
23512	"PRC2 is a tumor suppressor in Emicro-myc lymphomagenesis, because disease onset was accelerated by heterozygosity for Suz12 or by short hairpin RNA-mediated knockdown of Suz12 or Ezh2."
2145	"We show that, in contrast to PRC1, PRC2 is a tumor suppressor in Emicro-myc lymphomagenesis in lymphoma."
2146	"We show that, in contrast to PRC1, PRC2 is a tumor suppressor in Emicro-myc lymphomagenesis in lymphoma."
23512	"We show that, in contrast to PRC1, PRC2 is a tumor suppressor in Emicro-myc lymphomagenesis in lymphoma."
8726	"We show that, in contrast to PRC1, PRC2 is a tumor suppressor in Emicro-myc lymphomagenesis in lymphoma."
50486	"Roles for G0S2 were found in lactation, energy balance, and thermogenesis. This study provides a basis for tumor suppressive effects of G0S2 by regulating lipolysis."
6288	"homozygous SAA1.5/1.5 genotype appears to be a recessive susceptibility gene, which has lost the antiangiogenic function, whereas SAA1.1 and SAA1.3 are the dominant alleles of the tumor suppressor phenotype."
58508	this mouse model functionally validates MLL3 as a haploinsufficient 7q tumor suppressor and suggests a therapeutic option for this aggressive disease.
7403	H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia
5925	Tumor suppressor gene expression during normal and pathologic myocardial growth.
5933	Tumor suppressor gene expression during normal and pathologic myocardial growth.
7157	Tumor suppressor gene expression during normal and pathologic myocardial growth.
2120	This cell line will be very useful in studying the different mechanisms by which alterations of ETV6 contribute to leukemogenesis and in testing the hypothesis that ETV6 might act as a tumor suppressor gene.
7490	The Wilms tumor suppressor gene WT1 induces G1 arrest and apoptosis in myeloblastic leukemia M1 cells.
1500	Molecular mapping of chromosome 2 deletions in murine radiation-induced AML localizes a putative tumor suppressor gene to a 1.0 cM region homologous to human chromosome segment 11p11-12.

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