Found 484 literature records

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Entrez ID	Description
324	The APC tumor suppressor mutation was ssessed in the ability of apigenin in induce cell cycle arrest in HT29-APC cells.
23582	P0 overexpression may cause tumorigenesis in breast and liver tissues at least in part by inhibiting GCIP-mediated tumor suppression.
6678	"many of the genes within the CDR associated with the 5q- syndrome exhibit significantly decreased expression and that SPARC, as a potential tumor suppressor gene, may play a role in the pathogenesis of this disease"
6422	"Down-regulation of SFRP1 as a candidate tumor suppressor gene, triggered by the epigenetic and/or genetic events, could contribute to the oncogenesis of hepatic cell carcinoma."
9447	The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers.
2878	GPx3 is a novel tumor suppressor gene.
2878	The tumor suppressor activity of GPx3 seems to relate to its ability to suppress the expression of c-met.
27250	Downregulation of tumor suppressor Pdcd4 promotes colonic neoplastic transformation and tumor invasion
116173	"CMTM5 exhibits tumor suppressor activities, but with frequent epigenetic inactivation in carcinoma cell lines"
55294	FBXW7/hCDC4 is a general tumor suppressor in human cancer.
8190	A potential tumor suppressor role of Mia/Cd-rap in pituitary cells.
2903	NMDAR2A is commonly hypermethylated in primary human colorectal carcinoma and possesses tumor-suppressive activity.
50514	"Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma."
9052	"Gprc5a functions as a tumor suppressor in mouse lung, and human GPRC5A may share this property."
5333	Characterization of a novel tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinoma.
23671	data provides evidence to support the role of HPP1 as a tumor suppressor gene; activation of the STAT1 pathway likely represents the principal mediator of HPP1's tumor suppressive properties
112464	"hSRBC is a novel tumor suppressor whose epigenetic inactivation contributes to the malignant progression of gastric tumors, in part, through attenuated p53 response to stresses."
11197	"WIF1 may be a tumor suppressor, specifically in nonfunctioning pituitary tumors, and that the Wnt pathways are important in pituitary tumorigenesis."
999	"in addition to the previously implicated tumor suppressor activity of E-cadherin, modified forms of this glycoprotein might also play a role in growth promotion"
650	inactivating BMPR-IA and causing a loss of the BMP-2 tumor suppressor function in colon epithelial cells.
57491	These results therefore demonstrate that AHRR is a putative new tumor suppressor gene in multiple types of human cancers.
9940	DLEC1 is a candidate tumor suppressor gene that plays an important role in the development and progression of hepatocellular carcinoma.
11010	GLIPR1 is a proapoptotic tumor suppressor acting through the ROS-JNK pathway.
1029	A novel role for the Arf tumor suppressor protein in regulating phenotypes associated with tumor progression and metastasis in hepatocellular carcinoma cells.
26799	These findings establish snoRNA U50 as a reasonable candidate for the 6q tumor-suppressor gene in prostate cancer and likely in other types of cancers.
79365	role of the BHLHB3 protein as a tumor suppressor for lung cancer.
1687	DFNA5 is a novel tumor suppressor gene in CRC and a valuable molecular marker for human cancer
1540	Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling.
55743	"confirmed that the FHA domain of CHFR plays an important role in initiating a cell cycle arrest at G2/M, indicating a functional link exists between the anti-proliferative effects and checkpoint function of this tumor suppressor protein via this domain"
27250	mir-21 functions as an oncogene by a mechanism that involves translational repression of the tumor suppressor Pdcd4
6876	"acts as a tumour suppressor; expression is lost in prostate, breast and colon cancers"
55901	These findings suggest that THSD1 is a good candidate tumor suppressor gene.
23411	SIRT1 suppresses intestinal tumor formation in vitro
7490	The Wilms' tumor suppressor Wt1 activates transcription of the erythropoietin receptor in hematopoietic progenitor cells.
1029	Inactivation of the p19(ARF) tumor suppressor affects intestinal epithelial cell proliferation and integrity.
56999	These findings support ADAMTS9 as a putative tumor suppressor gene in vivo in NPC that is significantly associated with lymph node metastases.
139285	Tumor suppressor WTX gene mutation is rare in acute leukemias.
324	The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminus.
1474	Inactivation of the cystatin E/M tumor suppressor gene in cervical cancer.
407041	"miR-34b/c and BTG4 are novel tumor suppressors in colorectal cancer (CRC) and that the miR-34b/c CpG island, which bidirectionally regulates miR-34b/c and BTG4, is a frequent target of epigenetic silencing in CRC"
407042	"miR-34b/c and BTG4 are novel tumor suppressors in colorectal cancer (CRC) and that the miR-34b/c CpG island, which bidirectionally regulates miR-34b/c and BTG4, is a frequent target of epigenetic silencing in CRC"
54766	"miR-34b/c and BTG4 are novel tumor suppressors in colorectal cancer (CRC) and that the miR-34b/c CpG island, which bidirectionally regulates miR-34b/c and BTG4, is a frequent target of epigenetic silencing in CRC"
64682	Cdh1 may function as a component in tumor suppression via proteolysis of Skp2 in colorectal tumorigenesis and may serve as a prognostic marker in colon cancer patients.
7157	"The existence of a functional binding site for the tumor suppressor p53 near the proximal CCAAT box and the fact that the basal expression of annexin A1 in human colon adenocarcinoma cells is driven by p53 at the transcriptional level, is shown."
2137	Exostoses like-3 (EXTL3) is a putative tumour suppressor gene.
1634	Data demonstrate that decorin acts as a tumor suppressor gene and plays an important role in the maintenance of cell maturation and therefore homeostasis in the intestinal tract.
79192	"Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma. Overexpression of the three most frequently down-regulated candidates, SLC5A8, IRX1, and EBF3, validated their tumor suppressor potential by growth curve analysis and colony formation assay."
160728	Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma.
26038	"CHD5 is the strongest candidate tumor suppressor gene that is deleted from 1p36.31 in neuroblastomas, and inactivation of the second allele may occur by an epigenetic mechanism."
3248	15-PGDH is a direct downstream effector of HNF3beta and acts as a tumor suppressor in lung cancer.

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