SZGR2

Summary ?

GeneID	3688
Symbol	ITGB1
Synonyms	CD29\|FNRB\|GPIIA\|MDF2\|MSK12\|VLA-BETA\|VLAB
Description	integrin subunit beta 1
Reference	MIM:135630\|HGNC:HGNC:6153\|Ensembl:ENSG00000150093\|HPRD:00628\|Vega:OTTHUMG00000017928
Gene type	protein-coding
Map location	10p11.2
Pascal p-value	0.06
Sherlock p-value	0.624
Fetal beta	0.98
eGene	Caudate basal ganglia

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0109

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004872	receptor activity	IEA		-
GO:0005178	integrin binding	IEA		-
GO:0005488	binding	IEA		-
GO:0005515	protein binding	IEA		-
GO:0042802	identical protein binding	IPI		14681217
GO:0046982	protein heterodimerization activity	NAS		9552005
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000082	G1/S transition of mitotic cell cycle	IEA		-
GO:0001701	in utero embryonic development	IEA		-
GO:0007160	cell-matrix adhesion	IEA		-
GO:0007155	cell adhesion	IEA		-
GO:0007156	homophilic cell adhesion	TAS		10201960
GO:0007229	integrin-mediated signaling pathway	IEA		-
GO:0006968	cellular defense response	TAS		10201960
GO:0008284	positive regulation of cell proliferation	IEA		-
GO:0010002	cardioblast differentiation	IEA		-
GO:0007159	leukocyte adhesion	IDA		1715889
GO:0016477	cell migration	TAS		11919189
GO:0042685	cardioblast cell fate specification	IEA		-
GO:0030183	B cell differentiation	IC		1715889
GO:0044419	interspecies interaction between organisms	IEA		-
GO:0045596	negative regulation of cell differentiation	IEA		-
GO:0045214	sarcomere organization	IEA		-
GO:0051726	regulation of cell cycle	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0031594	neuromuscular junction	IDA	neuron, axon, Synap, Neurotransmitter (GO term level: 3)	9415431
GO:0031594	neuromuscular junction	IEA	neuron, axon, Synap, Neurotransmitter (GO term level: 3)	-
GO:0019717	synaptosome	IEA	Synap, Brain (GO term level: 7)	-
GO:0001726	ruffle	TAS		11919189
GO:0005783	endoplasmic reticulum	IDA		11256614
GO:0016021	integral to membrane	IEA		-
GO:0009986	cell surface	IDA		1715889
GO:0008305	integrin complex	IEA		-
GO:0008305	integrin complex	NAS		9552005
GO:0042383	sarcolemma	IDA		9415431
GO:0042383	sarcolemma	IEA		-
GO:0042470	melanosome	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTN1	FLJ40884	actinin, alpha 1	Reconstituted Complex	BioGRID	2116421
ACTN4	ACTININ-4 \| DKFZp686K23158 \| FSGS \| FSGS1	actinin, alpha 4	-	HPRD	2116421
ARHGAP5	GFI2 \| RhoGAP5 \| p190-B	Rho GTPase activating protein 5	-	HPRD	8537347
CANX	CNX \| FLJ26570 \| IP90 \| P90	calnexin	-	HPRD,BioGRID	8163531
CD151	GP27 \| MER2 \| PETA-3 \| RAPH \| SFA1 \| TSPAN24	CD151 molecule (Raph blood group)	Affinity Capture-Western	BioGRID	12175627
CD36	CHDS7 \| FAT \| GP3B \| GP4 \| GPIV \| PASIV \| SCARB3	CD36 molecule (thrombospondin receptor)	Affinity Capture-Western	BioGRID	11238109
CD46	MCP \| MGC26544 \| MIC10 \| TLX \| TRA2.10	CD46 molecule, complement regulatory protein	-	HPRD,BioGRID	10741407
CD47	IAP \| MER6 \| OA3	CD47 molecule	Affinity Capture-Western	BioGRID	10397731
CD63	LAMP-3 \| ME491 \| MLA1 \| OMA81H \| TSPAN30	CD63 molecule	Affinity Capture-Western	BioGRID	12175627
CD81	S5.7 \| TAPA1 \| TSPAN28	CD81 molecule	-	HPRD,BioGRID	10229664
CD82	4F9 \| C33 \| GR15 \| IA4 \| KAI1 \| R2 \| SAR2 \| ST6 \| TSPAN27	CD82 molecule	-	HPRD	8757325
CD9	5H9 \| BA2 \| BTCC-1 \| DRAP-27 \| GIG2 \| MIC3 \| MRP-1 \| P24 \| TSPAN29	CD9 molecule	Affinity Capture-Western	BioGRID	8630057 \|12175627
COL1A1	OI4	collagen, type I, alpha 1	Co-purification	BioGRID	2156854
FBXO2	FBG1 \| FBX2 \| Fbs1 \| NFB42	F-box protein 2	-	HPRD,BioGRID	12140560
FHL2	AAG11 \| DRAL \| SLIM3	four and a half LIM domains 2	Affinity Capture-Western Two-hybrid	BioGRID	10906324
FLNA	ABP-280 \| ABPX \| DKFZp434P031 \| FLN \| FLN1 \| FMD \| MNS \| NHBP \| OPD \| OPD1 \| OPD2	filamin A, alpha (actin binding protein 280)	-	HPRD,BioGRID	9722563 \|11807098
FLNB	ABP-278 \| AOI \| DKFZp686A1668 \| DKFZp686O033 \| FH1 \| FLN1L \| LRS1 \| SCT \| TABP \| TAP	filamin B, beta (actin binding protein 278)	-	HPRD,BioGRID	11807098
FLT4	FLT41 \| LMPH1A \| PCL \| VEGFR3	fms-related tyrosine kinase 4	-	HPRD,BioGRID	11553610
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	beta-1 integrin interacts with RACK1.	BIND	11884618
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	-	HPRD,BioGRID	9442085
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	An unspecified isoform of integrin-beta-1 interacts with RACK1.	BIND	15611085
HSPG2	PLC \| PRCAN \| SJA \| SJS \| SJS1	heparan sulfate proteoglycan 2	-	HPRD	9431988
ICAM4	CD242 \| LW	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	-	HPRD	11435317
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	beta-1 integrin interacts with IGF-IR.	BIND	11884618
ILK	DKFZp686F1765 \| P59	integrin-linked kinase	Integrin-beta-1 interacts with ILK.	BIND	8538749
ILK	DKFZp686F1765 \| P59	integrin-linked kinase	-	HPRD,BioGRID	8538749 \|9736715
ITGA1	CD49a \| VLA1	integrin, alpha 1	-	HPRD	8428973
ITGA1	CD49a \| VLA1	integrin, alpha 1	VLA1-alpha1 interacts with VLA1-beta.	BIND	1690718 \|1693624 \|3546305
ITGA10	PRO827	integrin, alpha 10	-	HPRD,BioGRID	9685391
ITGA11	HsT18964	integrin, alpha 11	Integrin-alpha11 interacts with Integrin-beta1.	BIND	10464311
ITGA11	HsT18964	integrin, alpha 11	-	HPRD	10486209
ITGA2	BR \| CD49B \| GPIa \| VLA-2 \| VLAA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	VLA2-alpha2 interacts with VLA2-beta.	BIND	1690718 \|1693624 \|3546305
ITGA3	CD49C \| FLJ34631 \| FLJ34704 \| GAP-B3 \| GAPB3 \| MSK18 \| VCA-2 \| VL3A \| VLA3a	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	VLA3-alpha3 interacts with VLA3-beta.	BIND	1690718 \|1693624 \|3546305
ITGA3	CD49C \| FLJ34631 \| FLJ34704 \| GAP-B3 \| GAPB3 \| MSK18 \| VCA-2 \| VL3A \| VLA3a	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	VLA3-alpha3 interacts with VLA3-beta	BIND	3546305
ITGA3	CD49C \| FLJ34631 \| FLJ34704 \| GAP-B3 \| GAPB3 \| MSK18 \| VCA-2 \| VL3A \| VLA3a	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	-	HPRD,BioGRID	15254262
ITGA4	CD49D \| IA4 \| MGC90518	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	VLA4-alpha4 interacts with VLA4-beta.	BIND	1693624 \|3546305
ITGA5	CD49e \| FNRA \| VLA5A	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	VLA5-alpha5 interacts with VLA5-beta.	BIND	1690718 \|1693624 \|3546305
ITGA6	CD49f \| DKFZp686J01244 \| FLJ18737 \| ITGA6B \| VLA-6	integrin, alpha 6	Affinity Capture-Western	BioGRID	9660880
ITGA6	CD49f \| DKFZp686J01244 \| FLJ18737 \| ITGA6B \| VLA-6	integrin, alpha 6	-	HPRD	9425259
ITGA6	CD49f \| DKFZp686J01244 \| FLJ18737 \| ITGA6B \| VLA-6	integrin, alpha 6	VLA6-alpha6 interacts with VLA-beta1.	BIND	1690718 \|1693624 \|2138612 \|2649503 \|2967289
ITGA8	-	integrin, alpha 8	-	HPRD,BioGRID	7768999
ITGA8	-	integrin, alpha 8	Integrin-alpha8 interacts with Integrin-beta1.	BIND	7559467
ITGA9	ALPHA-RLC \| ITGA4L \| RLC	integrin, alpha 9	Integrin-alpha9 interacts with Integrin-beta1.	BIND	8798654
ITGA9	ALPHA-RLC \| ITGA4L \| RLC	integrin, alpha 9	-	HPRD,BioGRID	8245132\|11462216
ITGAV	CD51 \| DKFZp686A08142 \| MSK8 \| VNRA	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	Integrin-alphaV interacts with Integrin-beta1	BIND	1690718 \|2138612
ITGB1BP1	DKFZp686K08158 \| ICAP-1A \| ICAP-1B \| ICAP-1alpha \| ICAP1 \| ICAP1A \| ICAP1B	integrin beta 1 binding protein 1	-	HPRD,BioGRID	9281591 \|11741908
ITGB1BP2	CHORDC3 \| ITGB1BP \| MELUSIN \| MGC119214 \| MSTP015	integrin beta 1 binding protein (melusin) 2	-	HPRD	12514714
ITGB1BP3	MGC126624 \| MIBP \| NRK2	integrin beta 1 binding protein 3	-	HPRD	10613898
ITGB5	FLJ26658	integrin, beta 5	-	HPRD	11462216
LAMA1	LAMA	laminin, alpha 1	-	HPRD,BioGRID	9688542
LGALS3BP	90K \| BTBD17B \| MAC-2-BP	lectin, galactoside-binding, soluble, 3 binding protein	-	HPRD	9501082
LGALS8	Gal-8 \| PCTA-1 \| PCTA1 \| Po66-CBP	lectin, galactoside-binding, soluble, 8	Affinity Capture-Western Reconstituted Complex	BioGRID	10852818
MAP4K4	FLH21957 \| FLJ10410 \| FLJ20373 \| FLJ90111 \| HGK \| KIAA0687 \| NIK	mitogen-activated protein kinase kinase kinase kinase 4	-	HPRD,BioGRID	11967148
MYO10	FLJ10639 \| FLJ21066 \| FLJ22268 \| FLJ43256 \| KIAA0799 \| MGC131988	myosin X	Integrin-beta-1 interacts with Myo10. This interaction was modeled on a demonstrated interaction between human integrin-beta-1 and bovine Myo10.	BIND	15156152
NME1	AWD \| GAAD \| NB \| NBS \| NDPK-A \| NDPKA \| NM23 \| NM23-H1	non-metastatic cells 1, protein (NM23A) expressed in	-	HPRD,BioGRID	11919189
PRKCA	AAG6 \| MGC129900 \| MGC129901 \| PKC-alpha \| PKCA \| PRKACA	protein kinase C, alpha	-	HPRD,BioGRID	12138200
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	-	HPRD	8649427
PXN	FLJ16691	paxillin	-	HPRD,BioGRID	7657702\|10804218
RAB8B	FLJ38125	RAB8B, member RAS oncogene family	Affinity Capture-Western	BioGRID	12639940
SLC3A2	4F2 \| 4F2HC \| 4T2HC \| CD98 \| CD98HC \| MDU1 \| NACAE	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	-	HPRD,BioGRID	12181350
TGOLN2	MGC14722 \| TGN38 \| TGN46 \| TGN48 \| TGN51 \| TTGN2	trans-golgi network protein 2	-	HPRD,BioGRID	11208159
THBS1	THBS \| TSP \| TSP1	thrombospondin 1	-	HPRD	11980922
TLN1	ILWEQ \| KIAA1027 \| TLN	talin 1	-	HPRD,BioGRID	11279249
TSPAN4	NAG-2 \| NAG2 \| TETRASPAN \| TM4SF7 \| TSPAN-4	tetraspanin 4	-	HPRD,BioGRID	9360996 \|10734060
VCAM1	CD106 \| DKFZp779G2333 \| INCAM-100 \| MGC99561	vascular cell adhesion molecule 1	-	HPRD	12097820
VCAN	CSPG2 \| DKFZp686K06110 \| ERVR \| PG-M \| WGN \| WGN1	versican	-	HPRD,BioGRID	11805102
YWHAB	GW128 \| HS1 \| KCIP-1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	-	HPRD,BioGRID	11313964

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG AXON GUIDANCE	129	103	All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
KEGG ECM RECEPTOR INTERACTION	84	53	All SZGR 2.0 genes in this pathway
KEGG CELL ADHESION MOLECULES CAMS	134	93	All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION	118	78	All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON	216	144	All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION	59	36	All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION	72	56	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER	84	67	All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM	85	65	All SZGR 2.0 genes in this pathway
KEGG ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ARVC	76	59	All SZGR 2.0 genes in this pathway
KEGG DILATED CARDIOMYOPATHY	92	68	All SZGR 2.0 genes in this pathway
BIOCARTA LYM PATHWAY	11	6	All SZGR 2.0 genes in this pathway
BIOCARTA AGR PATHWAY	36	31	All SZGR 2.0 genes in this pathway
BIOCARTA SPPA PATHWAY	22	18	All SZGR 2.0 genes in this pathway
BIOCARTA BCELLSURVIVAL PATHWAY	16	10	All SZGR 2.0 genes in this pathway
BIOCARTA LAIR PATHWAY	17	12	All SZGR 2.0 genes in this pathway
BIOCARTA EPHA4 PATHWAY	10	8	All SZGR 2.0 genes in this pathway
BIOCARTA ECM PATHWAY	24	17	All SZGR 2.0 genes in this pathway
BIOCARTA ERK PATHWAY	28	22	All SZGR 2.0 genes in this pathway
BIOCARTA INTEGRIN PATHWAY	38	29	All SZGR 2.0 genes in this pathway
BIOCARTA MCALPAIN PATHWAY	25	16	All SZGR 2.0 genes in this pathway
BIOCARTA MONOCYTE PATHWAY	11	5	All SZGR 2.0 genes in this pathway
BIOCARTA PTEN PATHWAY	18	14	All SZGR 2.0 genes in this pathway
BIOCARTA NKCELLS PATHWAY	20	13	All SZGR 2.0 genes in this pathway
BIOCARTA MET PATHWAY	37	30	All SZGR 2.0 genes in this pathway
BIOCARTA TFF PATHWAY	21	15	All SZGR 2.0 genes in this pathway
BIOCARTA UCALPAIN PATHWAY	18	11	All SZGR 2.0 genes in this pathway
PID PRL SIGNALING EVENTS PATHWAY	23	17	All SZGR 2.0 genes in this pathway
PID RHOA PATHWAY	45	33	All SZGR 2.0 genes in this pathway
PID INTEGRIN1 PATHWAY	66	44	All SZGR 2.0 genes in this pathway
PID INTEGRIN CS PATHWAY	26	16	All SZGR 2.0 genes in this pathway
PID ARF6 TRAFFICKING PATHWAY	49	34	All SZGR 2.0 genes in this pathway
PID REELIN PATHWAY	29	29	All SZGR 2.0 genes in this pathway
PID TCPTP PATHWAY	43	33	All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY	50	41	All SZGR 2.0 genes in this pathway
PID INTEGRIN A9B1 PATHWAY	25	18	All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY	102	78	All SZGR 2.0 genes in this pathway
PID SYNDECAN 4 PATHWAY	32	25	All SZGR 2.0 genes in this pathway
PID UPA UPAR PATHWAY	42	30	All SZGR 2.0 genes in this pathway
PID A6B1 A6B4 INTEGRIN PATHWAY	46	35	All SZGR 2.0 genes in this pathway
PID SYNDECAN 2 PATHWAY	33	27	All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID LYMPH ANGIOGENESIS PATHWAY	25	16	All SZGR 2.0 genes in this pathway
PID INTEGRIN A4B1 PATHWAY	33	24	All SZGR 2.0 genes in this pathway
PID FAK PATHWAY	59	45	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION	120	77	All SZGR 2.0 genes in this pathway
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	70	37	All SZGR 2.0 genes in this pathway
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	91	65	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	12	8	All SZGR 2.0 genes in this pathway
REACTOME BASIGIN INTERACTIONS	30	23	All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN CELL SURFACE INTERACTIONS	79	48	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME OTHER SEMAPHORIN INTERACTIONS	15	14	All SZGR 2.0 genes in this pathway
REACTOME SEMAPHORIN INTERACTIONS	68	53	All SZGR 2.0 genes in this pathway
REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	14	10	All SZGR 2.0 genes in this pathway
REACTOME CELL JUNCTION ORGANIZATION	78	43	All SZGR 2.0 genes in this pathway
REACTOME L1CAM INTERACTIONS	86	62	All SZGR 2.0 genes in this pathway
REACTOME SIGNAL TRANSDUCTION BY L1	34	25	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE DN	92	51	All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP	201	125	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
AKL HTLV1 INFECTION DN	68	41	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP	457	269	All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP	238	144	All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS UP	114	66	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN	459	276	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP	584	356	All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP	88	58	All SZGR 2.0 genes in this pathway
SASAKI TARGETS OF TP73 AND TP63	11	7	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
LIU BREAST CANCER	30	19	All SZGR 2.0 genes in this pathway
GUENTHER GROWTH SPHERICAL VS ADHERENT DN	26	19	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION UP	69	55	All SZGR 2.0 genes in this pathway
HE PTEN TARGETS UP	16	15	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215	893	528	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN	309	206	All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC	182	116	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP	151	100	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK DN	51	35	All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION	475	313	All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP	151	103	All SZGR 2.0 genes in this pathway
ZHOU TNF SIGNALING 4HR	54	36	All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP	206	118	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP	175	116	All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT	51	41	All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS DN	64	44	All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP	262	186	All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS DN	53	34	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C7	68	44	All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN	264	168	All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER T4	94	69	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR UV	63	44	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN	195	135	All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 2G	171	96	All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS UP	102	64	All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A UP	111	70	All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP	259	185	All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN	264	159	All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE	346	192	All SZGR 2.0 genes in this pathway
MELLMAN TUT1 TARGETS DN	47	29	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN	457	302	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN	668	419	All SZGR 2.0 genes in this pathway
LIU VAV3 PROSTATE CARCINOGENESIS DN	17	14	All SZGR 2.0 genes in this pathway
KAPOSI LIVER CANCER MET UP	18	11	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
DANG MYC TARGETS DN	31	25	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB	145	83	All SZGR 2.0 genes in this pathway
KANG AR TARGETS DN	19	12	All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN	315	215	All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7	403	240	All SZGR 2.0 genes in this pathway
PEDERSEN TARGETS OF 611CTF ISOFORM OF ERBB2	76	45	All SZGR 2.0 genes in this pathway
ABDELMOHSEN ELAVL4 TARGETS	16	13	All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL DN	146	88	All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES	275	155	All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP	489	314	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124/506	1095	1101	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
				hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
				hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
				hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-134	52	58	1A	hsa-miR-134^brain	UGUGACUGGUUGACCAGAGGG
miR-183	623	629	m8	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-223	183	189	1A	hsa-miR-223	UGUCAGUUUGUCAAAUACCCC
miR-29	830	836	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-320	608	614	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-493-5p	115	122	1A,m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: ITGB1