SZGR2

Summary ?

GeneID	4176
Symbol	MCM7
Synonyms	CDC47\|MCM2\|P1.1-MCM3\|P1CDC47\|P85MCM\|PNAS146\|PPP1R104
Description	minichromosome maintenance complex component 7
Reference	MIM:600592\|HGNC:HGNC:6950\|Ensembl:ENSG00000166508\|HPRD:01154\|Vega:OTTHUMG00000154671
Gene type	protein-coding
Map location	7q21.3-q22.1
Pascal p-value	0.461
Sherlock p-value	8.163E-4
Fetal beta	2.271
DMG	2 (# studies)
Support	Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
DMG:Nishioka_2013	Genome-wide DNA methylation analysis	The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls.	2
DMG:vanEijk_2014	Genome-wide DNA methylation analysis	This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250).	2
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.013

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg26023204	7	99699378	MCM7		-0.02	0.87	DMG:Nishioka_2013
cg13650156	7	99970502	MCM7	2.22E-6	3.895		DMG:vanEijk_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
CNPY2	0.86	0.81
COPS6	0.86	0.84
CCDC56	0.86	0.86
MYL6	0.86	0.83
CHMP2A	0.86	0.83
PSMA5	0.85	0.83
NHP2	0.85	0.82
SPAG7	0.85	0.85
TOMM5	0.85	0.84
TSTA3	0.84	0.81

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.26	-0.62	-0.56
AF347015.8	-0.59	-0.51
AF347015.2	-0.58	-0.51
AF347015.15	-0.58	-0.53
AF347015.18	-0.58	-0.51
MT-CYB	-0.56	-0.52
MT-CO2	-0.56	-0.47
AF347015.33	-0.56	-0.50
AF347015.27	-0.55	-0.52
MT-ATP8	-0.55	-0.52

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0003677	DNA binding	TAS		15538388
GO:0005515	protein binding	IPI		10518787 \|15538388 \|16438930
GO:0005524	ATP binding	IEA		-
GO:0017111	nucleoside-triphosphatase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006350	transcription	IEA		-
GO:0006270	DNA replication initiation	IEA		-
GO:0006260	DNA replication	EXP		12791985
GO:0006260	DNA replication	TAS		8798650
GO:0007049	cell cycle	IEA		-
GO:0006974	response to DNA damage stimulus	IMP		15538388
GO:0042325	regulation of phosphorylation	IMP		15538388
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000785	chromatin	TAS		8798650
GO:0005634	nucleus	IEA		-
GO:0005654	nucleoplasm	EXP		10436018 \|10846177 \|11095689 \|11931757 \|12045100 \|15226314 \|15707391
GO:0005737	cytoplasm	IDA		18029348
GO:0042555	MCM complex	IMP		15538388

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ATR	FRP1 \| MEC1 \| SCKL \| SCKL1	ataxia telangiectasia and Rad3 related	Affinity Capture-Western	BioGRID	15210935
ATRIP	DKFZp762J2115 \| FLJ12343 \| MGC20625 \| MGC21482 \| MGC26740	ATR interacting protein	Affinity Capture-Western	BioGRID	15210935
CCNH	CAK \| p34 \| p37	cyclin H	-	HPRD,BioGRID	11056214
CDC45L	CDC45 \| CDC45L2 \| PORC-PI-1	CDC45 cell division cycle 45-like (S. cerevisiae)	-	HPRD,BioGRID	10518787 \|12614612
CDC6	CDC18L \| HsCDC18 \| HsCDC6	cell division cycle 6 homolog (S. cerevisiae)	-	HPRD,BioGRID	10464337 \|12614612
CDC7	CDC7L1 \| HsCDC7 \| Hsk1 \| MGC117361 \| MGC126237 \| MGC126238 \| huCDC7	cell division cycle 7 homolog (S. cerevisiae)	-	HPRD,BioGRID	12614612
CDK7	CAK1 \| CDKN7 \| MO15 \| STK1 \| p39MO15	cyclin-dependent kinase 7	-	HPRD,BioGRID	11056214
CNOT8	CAF1 \| CALIF \| POP2 \| hCAF1	CCR4-NOT transcription complex, subunit 8	Affinity Capture-MS	BioGRID	17353931
CRLS1	C20orf155 \| CLS1 \| GCD10 \| dJ967N21.6	cardiolipin synthase 1	-	HPRD	12771218
DBF4	ASK \| CHIF \| DBF4A \| ZDBF1	DBF4 homolog (S. cerevisiae)	-	HPRD,BioGRID	12614612
FHL2	AAG11 \| DRAL \| SLIM3	four and a half LIM domains 2	-	HPRD,BioGRID	10649446
GIPC1	C19orf3 \| GIPC \| GLUT1CBP \| Hs.6454 \| IIP-1 \| MGC15889 \| MGC3774 \| NIP \| RGS19IP1 \| SEMCAP \| SYNECTIIN \| SYNECTIN \| TIP-2	GIPC PDZ domain containing family, member 1	Affinity Capture-MS	BioGRID	17353931
GSTK1	GST13	glutathione S-transferase kappa 1	Affinity Capture-MS	BioGRID	17353931
HIST3H3	H3.4 \| H3/g \| H3FT \| H3t \| MGC126886 \| MGC126888	histone cluster 3, H3	-	HPRD,BioGRID	8798650
IKBKG	AMCBX1 \| FIP-3 \| FIP3 \| Fip3p \| IKK-gamma \| IP \| IP1 \| IP2 \| IPD2 \| NEMO	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	-	HPRD	14743216
MBIP	-	MAP3K12 binding inhibitory protein 1	Two-hybrid	BioGRID	16189514
MCM10	CNA43 \| DNA43 \| MGC126776 \| PRO2249	minichromosome maintenance complex component 10	-	HPRD,BioGRID	11095689 \|15232106
MCM2	BM28 \| CCNL1 \| CDCL1 \| D3S3194 \| KIAA0030 \| MGC10606 \| MITOTIN \| cdc19	minichromosome maintenance complex component 2	Affinity Capture-Western Co-purification in vivo Reconstituted Complex Two-hybrid	BioGRID	8798650 \|9099751 \|10567526 \|10748114 \|12207017 \|12614612 \|12694531
MCM2	BM28 \| CCNL1 \| CDCL1 \| D3S3194 \| KIAA0030 \| MGC10606 \| MITOTIN \| cdc19	minichromosome maintenance complex component 2	-	HPRD	8798650 \|10567526 \|10748114 \|12207017
MCM2	BM28 \| CCNL1 \| CDCL1 \| D3S3194 \| KIAA0030 \| MGC10606 \| MITOTIN \| cdc19	minichromosome maintenance complex component 2	-	HPRD	8798650 \|10567526 \|10748114 \|12207017\|15232106
MCM3	HCC5 \| MGC1157 \| P1-MCM3 \| P1.h \| RLFB	minichromosome maintenance complex component 3	MCM3 interacts with MCM7.	BIND	15236977
MCM3	HCC5 \| MGC1157 \| P1-MCM3 \| P1.h \| RLFB	minichromosome maintenance complex component 3	-	HPRD	7601140 \|8631321 \|10464337
MCM3	HCC5 \| MGC1157 \| P1-MCM3 \| P1.h \| RLFB	minichromosome maintenance complex component 3	Mcm3 interacts with Mcm7.	BIND	15236977
MCM3	HCC5 \| MGC1157 \| P1-MCM3 \| P1.h \| RLFB	minichromosome maintenance complex component 3	Affinity Capture-Western Co-fractionation Two-hybrid	BioGRID	9099751 \|10464337 \|11779870 \|12614612
MCM4	CDC21 \| CDC54 \| MGC33310 \| P1-CDC21 \| hCdc21	minichromosome maintenance complex component 4	Affinity Capture-Western in vivo Reconstituted Complex	BioGRID	8798650 \|9099751 \|10748114 \|12207017 \|12694531
MCM4	CDC21 \| CDC54 \| MGC33310 \| P1-CDC21 \| hCdc21	minichromosome maintenance complex component 4	Mcm4 interacts with Mcm7.	BIND	15236977
MCM4	CDC21 \| CDC54 \| MGC33310 \| P1-CDC21 \| hCdc21	minichromosome maintenance complex component 4	-	HPRD	7601140 \|8631321 \|8798650 \|10567526 \|10748114 \|12207017
MCM4	CDC21 \| CDC54 \| MGC33310 \| P1-CDC21 \| hCdc21	minichromosome maintenance complex component 4	MCM4 interacts with MCM7.	BIND	15236977
MCM5	CDC46 \| MGC5315 \| P1-CDC46	minichromosome maintenance complex component 5	Affinity Capture-Western Two-hybrid	BioGRID	9099751 \|11248027 \|12614612
MCM5	CDC46 \| MGC5315 \| P1-CDC46	minichromosome maintenance complex component 5	-	HPRD	9099751 \|12614612
MCM6	MCG40308 \| Mis5 \| P105MCM	minichromosome maintenance complex component 6	-	HPRD	8798650 \|10567526 \|10748114 \|12207017
MCM6	MCG40308 \| Mis5 \| P105MCM	minichromosome maintenance complex component 6	Affinity Capture-Western in vivo Reconstituted Complex Two-hybrid	BioGRID	8798650 \|9099751 \|10748114 \|12207017 \|12614612 \|12694531
MCM6	MCG40308 \| Mis5 \| P105MCM	minichromosome maintenance complex component 6	-	HPRD	8798650 \|10567526 \|10748114 \|12207017\|12694531
MCM7	CDABP0042 \| CDC47 \| MCM2 \| P1.1-MCM3 \| P1CDC47 \| P85MCM \| PNAS-146	minichromosome maintenance complex component 7	Mcm7 interacts with itself.	BIND	15236977
MCM7	CDABP0042 \| CDC47 \| MCM2 \| P1.1-MCM3 \| P1CDC47 \| P85MCM \| PNAS-146	minichromosome maintenance complex component 7	Reconstituted Complex Two-hybrid	BioGRID	12614612 \|12694531
MCM8	C20orf154 \| MGC119522 \| MGC119523 \| MGC12866 \| MGC4816 \| REC \| dJ967N21.5	minichromosome maintenance complex component 8	-	HPRD,BioGRID	12771218
MNAT1	MAT1 \| RNF66 \| TFB3	menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)	-	HPRD,BioGRID	11056214
MYC	bHLHe39 \| c-Myc	v-myc myelocytomatosis viral oncogene homolog (avian)	Affinity Capture-MS	BioGRID	17353931
NEK6	SID6-1512	NIMA (never in mitosis gene a)-related kinase 6	Affinity Capture-MS	BioGRID	17353931
NFKBIA	IKBA \| MAD-3 \| NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	-	HPRD	14743216
ORC1L	HSORC1 \| ORC1 \| PARC1	origin recognition complex, subunit 1-like (yeast)	-	HPRD,BioGRID	12614612
ORC2L	ORC2	origin recognition complex, subunit 2-like (yeast)	-	HPRD,BioGRID	12614612
ORC3L	LAT \| LATHEO \| ORC3	origin recognition complex, subunit 3-like (yeast)	-	HPRD,BioGRID	12614612
ORC5L	ORC5 \| ORC5P \| ORC5T	origin recognition complex, subunit 5-like (yeast)	-	HPRD,BioGRID	12614612
PELO	CGI-17 \| PRO1770	pelota homolog (Drosophila)	Affinity Capture-MS	BioGRID	17353931
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	-	HPRD,BioGRID	9566894
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	MCM7 interacts with Rb.	BIND	9566894
RBL1	CP107 \| MGC40006 \| PRB1 \| p107	retinoblastoma-like 1 (p107)	-	HPRD,BioGRID	9566894
RBL1	CP107 \| MGC40006 \| PRB1 \| p107	retinoblastoma-like 1 (p107)	MCM7 interacts with p107.	BIND	9566894
RBL2	FLJ26459 \| P130 \| Rb2	retinoblastoma-like 2 (p130)	-	HPRD,BioGRID	9566894
RBL2	FLJ26459 \| P130 \| Rb2	retinoblastoma-like 2 (p130)	MCM7 interacts with p130.	BIND	9566894
RBM8A	BOV-1A \| BOV-1B \| BOV-1C \| MDS014 \| RBM8 \| RBM8B \| Y14 \| ZNRP \| ZRNP1	RNA binding motif protein 8A	Two-hybrid	BioGRID	16189514
RPA1	HSSB \| REPA1 \| RF-A \| RP-A \| RPA70	replication protein A1, 70kDa	-	HPRD,BioGRID	12614612
TH1L	HSPC130 \| NELF-C \| NELF-D \| TH1	TH1-like (Drosophila)	Affinity Capture-MS	BioGRID	17353931
TRAF6	MGC:3310 \| RNF85	TNF receptor-associated factor 6	Affinity Capture-MS	BioGRID	17353931
TREX1	AGS1 \| AGS5 \| CRV \| DKFZp434J0310 \| DRN3 \| HERNS	three prime repair exonuclease 1	-	HPRD	15210935
UBE3A	ANCR \| AS \| E6-AP \| EPVE6AP \| FLJ26981 \| HPVE6A	ubiquitin protein ligase E3A	-	HPRD,BioGRID	9852095

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG DNA REPLICATION	36	21	All SZGR 2.0 genes in this pathway
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
BIOCARTA MCM PATHWAY	18	8	All SZGR 2.0 genes in this pathway
PID ATR PATHWAY	39	25	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	31	16	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME ORC1 REMOVAL FROM CHROMATIN	67	37	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS	124	70	All SZGR 2.0 genes in this pathway
REACTOME M G1 TRANSITION	81	45	All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION	112	63	All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF DNA	92	53	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES	137	79	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES	172	98	All SZGR 2.0 genes in this pathway
REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	65	36	All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION	192	110	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	38	18	All SZGR 2.0 genes in this pathway
REACTOME UNWINDING OF DNA	11	6	All SZGR 2.0 genes in this pathway
REACTOME G2 M CHECKPOINTS	45	23	All SZGR 2.0 genes in this pathway
REACTOME S PHASE	109	66	All SZGR 2.0 genes in this pathway
REACTOME DNA STRAND ELONGATION	30	18	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP	368	234	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN	310	188	All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP	290	177	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP	430	232	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP	557	331	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF UP	115	78	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN	228	137	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
WANG ESOPHAGUS CANCER VS NORMAL UP	121	72	All SZGR 2.0 genes in this pathway
KAN RESPONSE TO ARSENIC TRIOXIDE	123	80	All SZGR 2.0 genes in this pathway
EGUCHI CELL CYCLE RB1 TARGETS	23	13	All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION	77	51	All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION HBZ	41	27	All SZGR 2.0 genes in this pathway
OXFORD RALA OR RALB TARGETS UP	48	23	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK	423	265	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
KAUFFMANN MELANOMA RELAPSE UP	61	25	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER	214	139	All SZGR 2.0 genes in this pathway
SCIAN CELL CYCLE TARGETS OF TP53 AND TP73 DN	22	14	All SZGR 2.0 genes in this pathway
BENPORATH ES 1	379	235	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE UP	80	54	All SZGR 2.0 genes in this pathway
MORI LARGE PRE BII LYMPHOCYTE UP	86	49	All SZGR 2.0 genes in this pathway
MORI IMMATURE B LYMPHOCYTE DN	90	55	All SZGR 2.0 genes in this pathway
MORI EMU MYC LYMPHOMA BY ONSET TIME UP	110	69	All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES	147	87	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE DN	66	43	All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN	160	110	All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS UP	108	75	All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC	182	116	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK DN	51	35	All SZGR 2.0 genes in this pathway
SHIPP DLBCL VS FOLLICULAR LYMPHOMA UP	45	30	All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER DN	76	57	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS UP	126	84	All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION	475	313	All SZGR 2.0 genes in this pathway
LEI MYB TARGETS	318	215	All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS DN	234	137	All SZGR 2.0 genes in this pathway
VERNELL RETINOBLASTOMA PATHWAY UP	70	47	All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 UP	65	44	All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP	151	103	All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER HEREDITARY VS SPORADIC	50	32	All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN	228	146	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 3	101	64	All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO CANTHARIDIN DN	69	46	All SZGR 2.0 genes in this pathway
ZHOU TNF SIGNALING 30MIN	54	36	All SZGR 2.0 genes in this pathway
SONG TARGETS OF IE86 CMV PROTEIN	60	42	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP	428	266	All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2	163	113	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP	148	96	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 16HR	40	24	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1	528	324	All SZGR 2.0 genes in this pathway
GAVIN IL2 RESPONSIVE FOXP3 TARGETS UP	19	12	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED	728	415	All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS	217	138	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS REQUIRE MYC	210	123	All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING UP	74	51	All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP	180	114	All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN	202	132	All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA E2	118	65	All SZGR 2.0 genes in this pathway
MOLENAAR TARGETS OF CCND1 AND CDK4 DN	58	25	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP	648	398	All SZGR 2.0 genes in this pathway
WHITEFORD PEDIATRIC CANCER MARKERS	116	63	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP	285	167	All SZGR 2.0 genes in this pathway
RAY TUMORIGENESIS BY ERBB2 CDC25A UP	104	57	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN	175	103	All SZGR 2.0 genes in this pathway
HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS	80	56	All SZGR 2.0 genes in this pathway
FRASOR RESPONSE TO SERM OR FULVESTRANT DN	50	29	All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS DN	142	79	All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE UP	212	128	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN	277	166	All SZGR 2.0 genes in this pathway
CROONQUIST IL6 DEPRIVATION DN	98	69	All SZGR 2.0 genes in this pathway
CROONQUIST NRAS SIGNALING DN	72	47	All SZGR 2.0 genes in this pathway
CROONQUIST NRAS VS STROMAL STIMULATION DN	99	65	All SZGR 2.0 genes in this pathway
ISHIDA E2F TARGETS	53	27	All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN	251	151	All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2	277	172	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
WU APOPTOSIS BY CDKN1A VIA TP53	55	31	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT	572	352	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS GROWING	243	155	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN	374	217	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP	229	149	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP	324	193	All SZGR 2.0 genes in this pathway
WIERENGA PML INTERACTOME	42	23	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP	281	183	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 6HR	85	49	All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 24HR	128	73	All SZGR 2.0 genes in this pathway

Gene Page: MCM7