Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
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Found 81 literature records
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Entrez ID
Description
8847
"Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT1, an alternative splice variant of the LEU2 gene."
22806
"Short isoforms of Aiolos were detected at low levels in bone marrow of normal volunters, but were not overexpressed in a patient with acute T-cell leukemia. Data for unaltered Aiolos indicates tumor suppressor function."
22807
Novel short isoforms of Helios are overexpressed in a patient with T-cell acute lymphoblastic leukemia and may contribute to the development of T-cell malignancies. Data for unaltered Helios indicates tumor suppressor function.
1029
Tumor suppressor gene p16 and Rb expression in gastric cardia precancerous lesions from subjects at a high incidence area in northern China.
2272
"FHIT gene is one of the chromosome 3p putative tumor suppressor genes involved in the pathogenesis of this highly malignant neoplasm, gallbladder carcinoma"
6767
"Characterization of FAM10A4, a member of the ST13 tumor suppressor gene family that maps to the 13q14.3 region associated with B-Cell leukemia, multiple myeloma, and prostate cancer."
1029
ATM and the ARF-p53 tumor suppressor pathway may cooperate in the pathogenesis of diffuse large B-cell lymphoma
283518
the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3; is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene
7490
Expression of Wilms' tumor suppressor in the liver with cirrhosis: relation to hepatocyte nuclear factor 4 and hepatocellular function.
10206
"RFP2, c13ORF1, and FAM10A4 are the most likely tumor suppressor gene candidates for B-cell chronic lymphocytic leukemia."
5728
Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop.
10206
Distinct organization of the candidate tumor suppressor gene RFP2 in human and mouse.
1030
The interferon regulatory factor ICSBP/IRF-8 in combination with PU.1 up-regulates expression of tumor suppressor p15(Ink4b) in murine myeloid cells.
2952
two TSGs were found located inside the deleted sequences of chromosome 22: SMARCB1 and GSTT1
7157
"observations indicate that p53 tumor suppressor , acting through suppression of nuclear factor kappa B, plays the role of a general ""buffer"" of innate immune response in vivo"
11083
Data suggest that Dido might be one of the tumor suppressor genes at chromosome 20q and that the Dido-targeted mouse may be a suitable model for studying myeloproliferative diseases and myelodysplastic syndromes.
5524
The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein.
135138
"candidate tumor suppressor genes PARK2 and PACRG are epigenetically regulated in human leukemia, suggesting that abnormal methylation and regulation of PARK2 and PACRG may play a role in the pathogenesis and development of this hematological neoplasm"
5071
"candidate tumor suppressor genes PARK2 and PACRG are epigenetically regulated in human leukemia, suggesting that abnormal methylation and regulation of PARK2 and PACRG may play a role in the pathogenesis and development of this hematological neoplasm"
6794
Reactive lipid species from cyclooxygenase-2 inactivate tumor suppressor LKB1/STK11: cyclopentenone prostaglandins and 4-hydroxy-2-nonenal covalently modify and inhibit the AMP-kinase kinase that modulates cellular energy homeostasis and protein translation.
1028
Compensation by tumor suppressor genes during retinal development in mice and humans.
5925
Compensation by tumor suppressor genes during retinal development in mice and humans.
5933
Compensation by tumor suppressor genes during retinal development in mice and humans.
5934
Compensation by tumor suppressor genes during retinal development in mice and humans.
6422
Compensation by tumor suppressor genes during retinal development in mice and humans.
324
genomic instability is an early event that occurs at precancerous stages prior to changes in tumor suppressor genes (p53 and APC) in Barrett's esophagus-associated tumorigenesis in patients
7157
genomic instability is an early event that occurs at precancerous stages prior to changes in tumor suppressor genes (p53 and adenomatosis polyposis coli) in Barrett's esophagus-associated tumorigenesis in patients
3394
Retroviral integration site analysis identifies ICSBP as a collaborating tumor suppressor gene in NUP98-TOP1-induced leukemia.
6282
"Expression of S100A11, a putative tumor suppressor gene, is increased in the early stage of pancreatic carcinogenesis and decreased during subsequent progression to cancer."
4763
The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways.
2952
Increased frequencies of glutathione-S-transferase (GSTM1 and GSTT1) null genotypes in Indian patients with chronic myeloid leukemia.
1027
"Results reveal a tumor suppressor role of p27 in chronic hepatocyte injury-induced liver tumorigenesis and, at the same time, the need to further study the mechanisms for tumor promotion by p27 inactivation."
1029
combined with screening of K-ras mutations and allelic losses of tumor suppressors p16 and DPC4 represents a very sensitive approach in screening for pancreatic malignancy.
4089
combined with screening of K-ras mutations and allelic losses of tumor suppressors p16 and DPC4 represents a very sensitive approach in screening for pancreatic malignancy.
1029
ARF tumor suppressor has a role in mouse models of acute leukemias [review]
8795
Thus TRAIL-R may function as an inflammation and tumor suppressor in multiple tissues in vivo.
1326
"Tpl2, a potent oncogene, functions as a tumor suppressor gene in chronically stimulated T cells."
3651
"PDX1 expression is lost in gastric cancers. Its effect on cell proliferation/apoptosis, migration and tumor formation in vitro and in vivo suggested that this protein functions as a putative tumor suppressor in gastric cancer."
406986
"Expression of miR-203 reduces ABL1 and BCR-ABL1 fusion protein levels and inhibits tumor cell proliferation in an ABL1-dependent manner, suggesting it may function as a tumor suppressor."
5925
These results indicate that PRMT5 overexpression epigenetically alters the transcription of key tumor suppressor genes.
8678
Control of autophagy by oncogenes and tumor suppressor genes.
4763
A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene.
57575
PCDH10 is a gastric tumor suppressor; its methylation at early stages of gastric carcinogenesis is an independent prognostic factor.
11184
Restoring wild-type HPK1 protein in pancreatic cancer cells led to the increase in p21 and p27 protein expression and cell cycle arrest. HPK1 may function as a novel tumor suppressor and its loss plays a critical role in pancreatic cancer.
7157
Suppression of tumor suppressor p53 functions together with nuclear calcium-regulated neuroprotective genes in a coordinate and synergistic manner to promote neuronal survival through the stabilization of mitochondria against cellular stresses.
7428
novel homeostatic control of keratinocyte proliferation and migration mediated via TAK1 regulation of von Hippel-Lindau tumor suppressor
406948
MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor suppressors
406950
MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor suppressors
7799
RIZ1 is potential CML tumor suppressor that is down-regulated during disease progression.
2309
Tumor suppressor FOXO3 participates in the regulation of intestinal inflammation.
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