Found 484 literature records

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Entrez ID	Description
2932	Our findings demonstrate an unrecognized role of GSK3beta in tumor cell survival and proliferation other than its predicted role as a tumor suppressor.
11186	Rassf1A acts as a tumor suppressor gene.
8854	The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer.
10912	Results show that GADD45G can act as a functional new-age tumor suppressor but being frequently inactivated epigenetically in multiple tumors.
26959	in myeloid cells HBP1 may serve as a tumor suppressor and a general differentiation inducer and may synergize with chemical differentiating agents to enhance lineage-specific differentiation
27030	Data show partial functional redundancy between MLH3 and PMS2 orthologues for mutation avoidance and show a role for Mlh3 in gastrointestinal and extragastrointestinal tumor suppression.
57575	"Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation."
10481	Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinoma.
135138	"candidate tumor suppressor genes PARK2 and PACRG are epigenetically regulated in human leukemia, suggesting that abnormal methylation and regulation of PARK2 and PACRG may play a role in the pathogenesis and development of this hematological neoplasm"
5071	"candidate tumor suppressor genes PARK2 and PACRG are epigenetically regulated in human leukemia, suggesting that abnormal methylation and regulation of PARK2 and PACRG may play a role in the pathogenesis and development of this hematological neoplasm"
79791	"FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex."
4221	The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.
23582	"In transgenic mice, GCIP functions as a transcriptional suppressor, regulates cyclin D1 expression, inhibits cell growth and colony formation in human HepG2 cells, suggesting GCIP plays a significant role in tumor initiation and development."
4830	These data imply that nm-23 may be tumor suppressor gene involved in neck squamous cell carcinomas but that it may not function as a tumor metastasis suppressor in high-stage laryngeal carcinoma.
5783	The PTPN13 protein has proapoptotic functions and can fuction as TSGs to suppress tumorigenesis.
324	The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid.
27316	hnRNP G is a tumor suppressor against HOSCC but its mechanisms of action remain to be further investigated
301	"Annexin I may have tumor suppressor functions in prostate cancer. The pro-apoptotic effect of ANX I involves the activation of p38 and JNK, which appears to shift the balance of signal transduction away from proliferation and toward apoptosis."
9940	Candidate tumor-suppressor gene DLEC1 is frequently downregulated by promoter hypermethylation and histone hypoacetylation in human epithelial ovarian cancer.
51741	WWOX overexpression in prostate cancer cells suppressed colony growth and induced apoptosis. Data are consistent with a role for WWOX as a prostate cancer tumor suppressor.
1654	"DDX3 suppresses tumor growth and transcriptionally activates the p21 promoter, and is inactivated through down-regulation of gene expression or alteration of subcellular localization in tumor cells; DDX3 might be a candidate tumor suppressor."
1029	Induction of the tumor-suppressor p16(INK4a) within regenerative epithelial crypts in ulcerative colitis.
10395	DLC1 appears to be a major tumor suppressor genes implicated in the pathogenesis of these tumors
6196	"RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer."
57509	"Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP."
4089	These data define the expression control of an essential BM component as a novel function for the tumor suppressor Smad4.
9314	The work identifies KLF4 as a putative tumor suppressor in B-cell malignancies.
10395	Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors.
90627	Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors.
23705	"TSLC1 inhibits nasopharyngeal carcinoma cell growth by arresting cells in G(0)-G(1) phase in normal culture conditions. Without serum, TSLC1 induced apoptosis. TSLC1 is a tumor suppressor gene in NPC; its loss is seen in lymphatic metastasis."
3490	IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis and its expression is associated with DNA hypomethylation of exon 1.
1474	Cystatin M may encode a novel epigenetically inactivated candidate tumor suppressor gene.
5728	"[Contiguous gene deletion within chromosome arm 10q is associated with juvenile polyposis of infancy, reflecting cooperation between the BMPR1A and PTEN tumor-suppressor genes]."
2066	These data suggest that ErbB4 behaves as a mammary tumor suppressor and that loss of ErbB4 coupling to growth arrest may be an important event in mammary tumorigenesis.
324	Characterization of a 60S complex of the adenomatous polyposis coli tumor suppressor protein.
10481	HOXB13 is downregulated by methylation and functions as a tumor suppressor in malignant melanoma.
6850	Syk tyrosine kinase is downregulated by methylation and functions as a tumor suppressor in malignant melanoma.
7428	"VHL protein exerts its tumor suppressor action, at least partially, via inhibition of p22phox-based Nox4/Nox1 NADPH oxidase-dependent reactive oxygen species generation"
7020	data provide evidence that AP-2alpha acts as a tumor suppressor gene in colon cancer
1030	Loss of the tumor suppressor p15Ink4b enhances myeloid progenitor formation from common myeloid progenitors.
3490	IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis.
22943	Dickkopf-1 is an epigenetically silenced candidate tumor suppressor gene in medulloblastoma.
11197	"Thus, WIF1 functions as a tumor suppressor for both NPC and ESCC through suppressing the Wnt-signaling pathway, but is frequently silenced by epigenetic mechanism in a tumor-specific way."
2272	"absence or poor expression of the Fhit protein in anal cancers suggests a role for this tumor suppressor gene product, as a risk factor, in the onset of this cancer, as reported before for other gastrointestinal tumors"
11334	Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1.
55749	"CARP-1 is a suppressor of breast cancer growth, and its expression is diminished in tumors, in part, by methylation-dependent silencing"
55743	CHFR has a role as a tumor suppressor in breast cancer
5925	"RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, E6, E7, cyclin D1 (CCND1), and c-MYC."
7157	"RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, E6, E7, cyclin D1 (CCND1), and c-MYC."
4015	BCL2 repression by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells

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