ERGR - Ethanol-Related Gene Resource

All datasets list (sort by species):

Dataset_name or Publication PMID Species Method Tissue Phenotype or Treatment Publication

11093800 Human Microarray SH-SY5Y neuroblastoma cells Ethanol response Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
11141048 Human Microarray Frontal cortex Alcohol dependence (AD)/Alcohol abuse/Alcoholism Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
12065639 Human Microarray Frontal and motor cortices Alcohol dependence (AD)/Alcohol abuse/Alcoholism Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
12774316 Human Microarray Temporal cortex Alcohol dependence (AD)/Alcohol abuse/Alcoholism Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
15236863 Human Microarray Prefrontal cortex Alcohol dependence (AD)/Alcohol abuse/Alcoholism Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
15816859 Human Microarray Prefrontal cortex and nucleus accumbens Alcohol dependence (AD)/Alcohol abuse/Alcoholism Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
16292326 Human Microarray Frontal cortex Alcohol dependence (AD)/Alcohol abuse/Alcoholism Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
18477577 Human Addiction array gene list Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
16894614 Human Association Alcohol dependence (AD)/Alcohol abuse/Alcoholism Johnson et al. Am J Med Genet B Neuropsychiatr Genet. (2006) Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. PubMed
Literature search Human Literature search
15211641 Human Linkage Alcoholism phenotype along with age, gender, and P300 or constraint Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
16534506 Human Linkage ADSX (number of DSM-IV AD symptoms) Prescott et al. Mol Psychiatry. (2006) Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. PubMed
17067344 Human Linkage WDSFS (withdrawal symptoms factor score), ONSET (age at onset of AD), ISENS (initial sensitivity), TOLMX (tolerance/maximum drinking) Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
HuGE Navigator Human Literature data mining Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
11410715 Mouse Microarray Whole brain Ethanol sensitivity Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
12805289 Mouse Microarray and QTL Whole brain Acute functional tolerance to ethanol Tabakoff et al. J Neurosci. (2003) Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. PubMed
15002731 Mouse Microarray Whole brain Acute ethanol response Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
15282116 Mouse Microarray Striata Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
15668661 Mouse Microarray Fetal brain Ethanol response Hard et al. J Lab Clin Med. (2005) Gene-expression analysis after alcohol exposure in the developing mouse. PubMed
16465594 Mouse Microarray and QTL Cerebellum Ethanol sensitivity MacLaren et al. Mamm Genome. (2006) Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. PubMed
16783646 Mouse Microarray and QTL Whole brain Alcohol preference, acute functional tolerance Saba et al. Mamm Genome. (2006) Candidate genes and their regulatory elements: alcohol preference and tolerance. PubMed
17295719 Mouse Microarray Cultured fetal mouse cortical neurons Ethanol response Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
15745951 Mouse Microarray Nucleus accumbens, prefrontal cortex, and ventral tegmental area Acute ethanol response Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
16618939 Mouse Microarray Whole brain Alcohol preference Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
MouseQTL Mouse QTL Acute Alcohol Withdrawal, Chronic Alcohol Withdrawal, Alcohol Preference Drinking, Alcohol Stimulated Activity, Alcohol-induced Loss of Righting Reflex, Alcohol Acceptance PARC Alcohol QTLs by Phenotype at Portland Alcohol Research Center.
15597075 Mouse Microarray and QTL Brain Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
11772933 Rat Microarray Frontal cortex and amygdala Ethanol response Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
15660665 Rat Microarray Hippocampus Alcohol-preferring, alcohol-nonpreferring Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
15846778 Rat Microarray Frontal cortex Alcohol-preferring, alcohol-nonpreferring Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
17451403 Rat Microarray and QTL Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum Alcohol Preference, alcohol-preferring, alcohol-nonpreferring Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed
17517326 Rat Microarray Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus Alcohol-preferring, alcohol-nonpreferring Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
18405950 Rat Microarray Nucleus accumbens and amygdala Ethanol self-administration, alcohol-preferring Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
15028283 Worm Microarray Ethanol response Kwon et al. Genomics. (2004) Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans. PubMed
17054780 Fly Microarray Ethanol response Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
17973985 Fly Microarray Ethanol sensitivity Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed

Dataset_name or Publication PMID	Species	Method	Tissue	Phenotype or Treatment	Publication
11093800	Human	Microarray	SH-SY5Y neuroblastoma cells	Ethanol response	Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
11141048	Human	Microarray	Frontal cortex	Alcohol dependence (AD)/Alcohol abuse/Alcoholism	Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
12065639	Human	Microarray	Frontal and motor cortices	Alcohol dependence (AD)/Alcohol abuse/Alcoholism	Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
12774316	Human	Microarray	Temporal cortex	Alcohol dependence (AD)/Alcohol abuse/Alcoholism	Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
15236863	Human	Microarray	Prefrontal cortex	Alcohol dependence (AD)/Alcohol abuse/Alcoholism	Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
15816859	Human	Microarray	Prefrontal cortex and nucleus accumbens	Alcohol dependence (AD)/Alcohol abuse/Alcoholism	Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
16292326	Human	Microarray	Frontal cortex	Alcohol dependence (AD)/Alcohol abuse/Alcoholism	Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
18477577	Human	Addiction array gene list			Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
16894614	Human	Association		Alcohol dependence (AD)/Alcohol abuse/Alcoholism	Johnson et al. Am J Med Genet B Neuropsychiatr Genet. (2006) Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. PubMed
Literature search	Human	Literature search
15211641	Human	Linkage		Alcoholism phenotype along with age, gender, and P300 or constraint	Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
16534506	Human	Linkage		ADSX (number of DSM-IV AD symptoms)	Prescott et al. Mol Psychiatry. (2006) Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. PubMed
17067344	Human	Linkage		WDSFS (withdrawal symptoms factor score), ONSET (age at onset of AD), ISENS (initial sensitivity), TOLMX (tolerance/maximum drinking)	Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
HuGE Navigator	Human	Literature data mining		Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism	Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
11410715	Mouse	Microarray	Whole brain	Ethanol sensitivity	Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
12805289	Mouse	Microarray and QTL	Whole brain	Acute functional tolerance to ethanol	Tabakoff et al. J Neurosci. (2003) Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. PubMed
15002731	Mouse	Microarray	Whole brain	Acute ethanol response	Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
15282116	Mouse	Microarray	Striata	Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration	Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
15668661	Mouse	Microarray	Fetal brain	Ethanol response	Hard et al. J Lab Clin Med. (2005) Gene-expression analysis after alcohol exposure in the developing mouse. PubMed
16465594	Mouse	Microarray and QTL	Cerebellum	Ethanol sensitivity	MacLaren et al. Mamm Genome. (2006) Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. PubMed
16783646	Mouse	Microarray and QTL	Whole brain	Alcohol preference, acute functional tolerance	Saba et al. Mamm Genome. (2006) Candidate genes and their regulatory elements: alcohol preference and tolerance. PubMed
17295719	Mouse	Microarray	Cultured fetal mouse cortical neurons	Ethanol response	Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
15745951	Mouse	Microarray	Nucleus accumbens, prefrontal cortex, and ventral tegmental area	Acute ethanol response	Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
16618939	Mouse	Microarray	Whole brain	Alcohol preference	Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
MouseQTL	Mouse	QTL		Acute Alcohol Withdrawal, Chronic Alcohol Withdrawal, Alcohol Preference Drinking, Alcohol Stimulated Activity, Alcohol-induced Loss of Righting Reflex, Alcohol Acceptance	PARC Alcohol QTLs by Phenotype at Portland Alcohol Research Center.
15597075	Mouse	Microarray and QTL	Brain	Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity	Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
11772933	Rat	Microarray	Frontal cortex and amygdala	Ethanol response	Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
15660665	Rat	Microarray	Hippocampus	Alcohol-preferring, alcohol-nonpreferring	Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
15846778	Rat	Microarray	Frontal cortex	Alcohol-preferring, alcohol-nonpreferring	Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
17451403	Rat	Microarray and QTL	Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum	Alcohol Preference, alcohol-preferring, alcohol-nonpreferring	Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed
17517326	Rat	Microarray	Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus	Alcohol-preferring, alcohol-nonpreferring	Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
18405950	Rat	Microarray	Nucleus accumbens and amygdala	Ethanol self-administration, alcohol-preferring	Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
15028283	Worm	Microarray		Ethanol response	Kwon et al. Genomics. (2004) Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans. PubMed
17054780	Fly	Microarray		Ethanol response	Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
17973985	Fly	Microarray		Ethanol sensitivity	Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed