SZGR2

Summary ?

GeneID	6502
Symbol	SKP2
Synonyms	FBL1\|FBXL1\|FLB1\|p45
Description	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
Reference	MIM:601436\|HGNC:HGNC:10901\|Ensembl:ENSG00000145604\|HPRD:03256\|Vega:OTTHUMG00000131106
Gene type	protein-coding
Map location	5p13
Pascal p-value	0.091
Sherlock p-value	0.01
Fetal beta	1.243

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
IRX3	0.77	0.28
C5orf38	0.70	0.20
GMPR	0.70	0.15
LFNG	0.70	0.50
EDNRB	0.67	0.37
AC015908.2	0.66	0.25
ENTPD2	0.66	0.38
C10orf105	0.66	0.33
RPE65	0.63	0.25
FIBIN	0.62	0.50

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
CRYM	-0.24	-0.28
ITPKA	-0.23	-0.26
ABCC12	-0.23	-0.19
TAGLN3	-0.22	-0.30
CHN1	-0.22	-0.14
CA11	-0.22	-0.24
CAP2	-0.22	-0.15
ARPP19	-0.22	-0.20
SLC26A4	-0.21	-0.17
RGS4	-0.21	-0.17

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CCNA2	CCN1 \| CCNA	cyclin A2	-	HPRD,BioGRID	9858587
CCNE1	CCNE	cyclin E1	-	HPRD,BioGRID	11237742
CCNT1	CCNT \| CYCT1	cyclin T1	-	HPRD	11689688
CDC34	E2-CDC34 \| UBC3 \| UBE2R1	cell division cycle 34 homolog (S. cerevisiae)	-	HPRD	9430629
CDK2	p33(CDK2)	cyclin-dependent kinase 2	Affinity Capture-Western Reconstituted Complex	BioGRID	10559858 \|15355997
CDK2	p33(CDK2)	cyclin-dependent kinase 2	-	HPRD	10386600
CDK9	C-2k \| CDC2L4 \| CTK1 \| PITALRE \| TAK	cyclin-dependent kinase 9	-	HPRD,BioGRID	11689688
CDK9	C-2k \| CDC2L4 \| CTK1 \| PITALRE \| TAK	cyclin-dependent kinase 9	-	HPRD	11689688 \|12861003
CDKN1B	CDKN4 \| KIP1 \| MEN1B \| MEN4 \| P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	-	HPRD	10559916
CDKN1B	CDKN4 \| KIP1 \| MEN1B \| MEN4 \| P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	Affinity Capture-Western Biochemical Activity Reconstituted Complex	BioGRID	12042314 \|12140288 \|12813041
CDKN1B	CDKN4 \| KIP1 \| MEN1B \| MEN4 \| P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	CDKN1B (p27Kip1) interacts with SKP2 (p45Skp2).	BIND	15735731
CDKN1B	CDKN4 \| KIP1 \| MEN1B \| MEN4 \| P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	Skp2 interacts with p27.	BIND	15469821
CDKN1C	BWCR \| BWS \| KIP2 \| WBS \| p57	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	-	HPRD,BioGRID	12925736
CDT1	DUP \| RIS2	chromatin licensing and DNA replication factor 1	-	HPRD,BioGRID	12840033
CKS1B	CKS1 \| PNAS-16 \| PNAS-18 \| ckshs1	CDC28 protein kinase regulatory subunit 1B	Affinity Capture-Western Reconstituted Complex	BioGRID	11231585 \|12140288 \|12813041
CKS1B	CKS1 \| PNAS-16 \| PNAS-18 \| ckshs1	CDC28 protein kinase regulatory subunit 1B	-	HPRD	11231585 \|12813041
CUL1	MGC149834 \| MGC149835	cullin 1	-	HPRD,BioGRID	9430629
CUL1	MGC149834 \| MGC149835	cullin 1	Skp2-Fbox interacts with Cul1 [15-410] to form part of the Cul1-Rbx1-Skp1-F Boxskp2 Scf Ubiquitin Ligase complex.	BIND	11961546
E2F1	E2F-1 \| RBAP1 \| RBBP3 \| RBP3	E2F transcription factor 1	-	HPRD,BioGRID	10559858
FZR1	CDC20C \| CDH1 \| FZR \| FZR2 \| HCDH \| HCDH1 \| KIAA1242	fizzy/cell division cycle 20 related 1 (Drosophila)	Cdh1 interacts with Skp2.	BIND	15014503
GPS1	COPS1 \| CSN1 \| MGC71287	G protein pathway suppressor 1	-	HPRD	11337588
MYBL2	B-MYB \| BMYB \| MGC15600	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	-	HPRD,BioGRID	10871850
ORC1L	HSORC1 \| ORC1 \| PARC1	origin recognition complex, subunit 1-like (yeast)	-	HPRD,BioGRID	11931757
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	Skp2 interacts with Rb.	BIND	15469821
SKP1	EMC19 \| MGC34403 \| OCP-II \| OCP2 \| SKP1A \| TCEB1L \| p19A	S-phase kinase-associated protein 1	Skp2-Fbox interacts with SKP1A to form part of the Cul1-Rbx1-Skp1-F Boxskp2 Scf Ubiquitin Ligase complex.	BIND	11961546
SKP1	EMC19 \| MGC34403 \| OCP-II \| OCP2 \| SKP1A \| TCEB1L \| p19A	S-phase kinase-associated protein 1	-	HPRD	9430629 \|9827542\|11099048
SKP1	EMC19 \| MGC34403 \| OCP-II \| OCP2 \| SKP1A \| TCEB1L \| p19A	S-phase kinase-associated protein 1	Affinity Capture-Western Co-crystal Structure Reconstituted Complex Two-hybrid	BioGRID	9827542 \|10531035 \|10559858 \|10918611 \|11099048 \|12609982
TCF3	E2A \| ITF1 \| MGC129647 \| MGC129648 \| bHLHb21	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	-	HPRD,BioGRID	14592976
TSC2	FLJ43106 \| LAM \| TSC4	tuberous sclerosis 2	Phenotypic Suppression	BioGRID	15355997
UXT	ART-27	ubiquitously-expressed transcript	STAP1 interacts with SKP2.	BIND	14615539
WEE1	DKFZp686I18166 \| FLJ16446 \| WEE1A \| WEE1hu	WEE1 homolog (S. pombe)	Wee1A interacts with an unspecified isoform of SKP2.	BIND	15070733

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
KEGG UBIQUITIN MEDIATED PROTEOLYSIS	138	98	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER	84	67	All SZGR 2.0 genes in this pathway
BIOCARTA G1 PATHWAY	28	21	All SZGR 2.0 genes in this pathway
BIOCARTA SKP2E2F PATHWAY	10	6	All SZGR 2.0 genes in this pathway
BIOCARTA P27 PATHWAY	13	10	All SZGR 2.0 genes in this pathway
PID NOTCH PATHWAY	59	49	All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY	49	43	All SZGR 2.0 genes in this pathway
PID MYC PATHWAY	25	22	All SZGR 2.0 genes in this pathway
PID FOXM1 PATHWAY	40	30	All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY	59	50	All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY	65	46	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	65	40	All SZGR 2.0 genes in this pathway
REACTOME G1 PHASE	38	23	All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION	112	63	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES	137	79	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MITOTIC CELL CYCLE	85	46	All SZGR 2.0 genes in this pathway
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	72	38	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	251	156	All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	212	129	All SZGR 2.0 genes in this pathway
REACTOME S PHASE	109	66	All SZGR 2.0 genes in this pathway
REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	56	34	All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN	309	191	All SZGR 2.0 genes in this pathway
DAVICIONI PAX FOXO1 SIGNATURE IN ARMS UP	59	38	All SZGR 2.0 genes in this pathway
IGARASHI ATF4 TARGETS DN	90	65	All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP	255	177	All SZGR 2.0 genes in this pathway
DAVICIONI RHABDOMYOSARCOMA PAX FOXO1 FUSION UP	64	37	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST NORMAL DUCTAL VS LOBULAR UP	68	40	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN	431	263	All SZGR 2.0 genes in this pathway
PRAMOONJAGO SOX4 TARGETS DN	51	35	All SZGR 2.0 genes in this pathway
PUIFFE INVASION INHIBITED BY ASCITES UP	82	51	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN	460	312	All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP	372	227	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP	430	232	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP	233	161	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE DN	53	25	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP	457	269	All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS UP	114	66	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP	557	331	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN	459	276	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS UP	149	84	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
KONG E2F3 TARGETS	97	58	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL	330	215	All SZGR 2.0 genes in this pathway
HONRADO BREAST CANCER BRCA1 VS BRCA2	18	12	All SZGR 2.0 genes in this pathway
SNIJDERS AMPLIFIED IN HEAD AND NECK TUMORS	37	27	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS UP	110	71	All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK	168	103	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK	423	265	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
PUJANA BRCA CENTERED NETWORK	117	72	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN	637	377	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 DN	176	104	All SZGR 2.0 genes in this pathway
STEGMEIER PRE-MITOTIC CELL CYCLE REGULATORS	11	8	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN	169	102	All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN	289	166	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS UP	126	84	All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA UP	50	35	All SZGR 2.0 genes in this pathway
VERNELL RETINOBLASTOMA PATHWAY UP	70	47	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP	428	266	All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE	261	166	All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN	314	188	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4	307	185	All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED	728	415	All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS RESPONSIVE TO ESTROGEN DN	41	26	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN	202	132	All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN	249	165	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP	648	398	All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C	463	262	All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP	425	253	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP	294	199	All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR DN	41	17	All SZGR 2.0 genes in this pathway
LIN NPAS4 TARGETS DN	68	48	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN	342	220	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C CLUSTER UP	38	26	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C UP	47	29	All SZGR 2.0 genes in this pathway
REICHERT G1S REGULATORS AS PI3K TARGETS	8	6	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN	277	166	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
CROONQUIST IL6 DEPRIVATION DN	98	69	All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER WITH BRCA1 MUTATED UP	56	27	All SZGR 2.0 genes in this pathway
STEIN ESR1 TARGETS	85	55	All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2	277	172	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA3 DN	69	38	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G1 S	147	76	All SZGR 2.0 genes in this pathway
STAMBOLSKY BOUND BY MUTATED TP53	18	12	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT	572	352	All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN	414	237	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP	324	193	All SZGR 2.0 genes in this pathway
GABRIELY MIR21 TARGETS	289	187	All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS UP	84	51	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS DN	72	52	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE	227	151	All SZGR 2.0 genes in this pathway
YU BAP1 TARGETS	29	21	All SZGR 2.0 genes in this pathway

Gene Page: SKP2