Gene Page: XPO1

Summary ?
GeneID7514
SymbolXPO1
SynonymsCRM1|emb|exp1
Descriptionexportin 1
ReferenceMIM:602559|HGNC:HGNC:12825|Ensembl:ENSG00000082898|HPRD:03975|Vega:OTTHUMG00000152316
Gene typeprotein-coding
Map location2p15
Pascal p-value0.081
Sherlock p-value0.136
Fetal beta0.821
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg09455096261765470XPO11.45E-9-0.0081.39E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1872418chr33888893XPO175140.11trans
rs9921236chr1688117014XPO175140.15trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
Crm1 interacts with U3 snoRNABIND15574333 
ADARADAR1 | DRADA | DSH | DSRAD | G1P1 | IFI-4 | IFI4 | K88dsRBP | p136adenosine deaminase, RNA-specific-HPRD,BioGRID11604520 
AHR-aryl hydrocarbon receptor-HPRD12065584 
ANP32AC15orf1 | I1PP2A | LANP | MAPM | MGC119787 | MGC150373 | PHAP1 | PHAPI | PP32acidic (leucine-rich) nuclear phosphoprotein 32 family, member AAffinity Capture-WesternBioGRID11565755 
APCBTPS2 | DP2 | DP2.5 | DP3 | GSadenomatous polyposis coliAffinity Capture-Western
Reconstituted Complex		BioGRID12070164 
ARNTHIF-1beta | HIF1B | HIF1BETA | TANGO | bHLHe2aryl hydrocarbon receptor nuclear translocatorAffinity Capture-WesternBioGRID12065584 
BECN1ATG6 | VPS30 | beclin1beclin 1, autophagy related-HPRD11309306 
CCND1BCL1 | D11S287E | PRAD1 | U21B31cyclin D1Reconstituted ComplexBioGRID12529437 
CDKN1BCDKN4 | KIP1 | MEN1B | MEN4 | P27KIP1cyclin-dependent kinase inhibitor 1B (p27, Kip1)p27Kip1 interacts with CRM1.BIND11889117 
CDKN1BCDKN4 | KIP1 | MEN1B | MEN4 | P27KIP1cyclin-dependent kinase inhibitor 1B (p27, Kip1)-HPRD,BioGRID11889117 |12529437 
CIITAC2TA | CIITAIV | MHC2TA | NLRAclass II, major histocompatibility complex, transactivator-HPRD,BioGRID12517958 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)-HPRD,BioGRID11839808 
DDX3XDBX | DDX14 | DDX3 | HLP2DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linkedDDX3 interacts with CRM1.BIND15507209 
E2F5E2F-5E2F transcription factor 5, p130-binding-HPRD12089160 
EIF5AA | EIF-5A | EIF5A1 | MGC104255 | MGC99547 | uORFeukaryotic translation initiation factor 5A-HPRD,BioGRID10381392 
ELAVL1ELAV1 | HUR | Hua | MelGELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)-HPRD,BioGRID11565755 
ERFPE-2 | PE2Ets2 repressor factor-HPRD14729966 
FOXO4AFX | AFX1 | MGC120490 | MLLT7forkhead box O4-HPRD,BioGRID11313479 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3-HPRD,BioGRID11779848 
KIF17KIAA1405 | KIF17B | KIF3Xkinesin family member 17-HPRD,BioGRID12493914 
NF2ACN | BANF | SCHneurofibromin 2 (merlin)-HPRD,BioGRID12217955 
NMD3CGI-07 | FLJ21053NMD3 homolog (S. cerevisiae)-HPRD,BioGRID12724356 
NPM1B23 | MGC104254 | NPMnucleophosmin (nucleolar phosphoprotein B23, numatrin)An unspecified isoform of NPM1 (NPM) interacts with XPO1 (CRM1).BIND16041368 
NUP153HNUP153 | N153nucleoporin 153kDa-HPRD,BioGRID10202161 
NUP214CAIN | CAN | D9S46E | MGC104525 | N214nucleoporin 214kDa-HPRD11551912 
NUP214CAIN | CAN | D9S46E | MGC104525 | N214nucleoporin 214kDaAffinity Capture-WesternBioGRID11425870 
NUP50MGC39961 | NPAP60 | NPAP60Lnucleoporin 50kDa-HPRD,BioGRID10891499 
NUP62DKFZp547L134 | FLJ20822 | FLJ43869 | IBSN | MGC841 | SNDI | p62nucleoporin 62kDa-HPRD,BioGRID10330396 
NUPL2CG1 | NLP-1 | NLP_1 | hCG1nucleoporin like 2NUPL2 (NLP-1) interacts with XPO1 (CRM-1).BIND10358091 
NXF3-nuclear RNA export factor 3-HPRD,BioGRID11545741 
NXT1MTR2 | P15NTF2-like export factor 1-HPRD,BioGRID11149927 
ORC1LHSORC1 | ORC1 | PARC1origin recognition complex, subunit 1-like (yeast)-HPRD11716535 
PHAXFLJ13193 | RNUXAphosphorylated adaptor for RNA export-HPRD10786834 
RANARA24 | Gsp1 | TC4RAN, member RAS oncogene family-HPRD,BioGRID9323133 
RANBP1HTF9A | MGC88701RAN binding protein 1Reconstituted ComplexBioGRID10601307 |10779340 
RANBP2NUP358 | TRP1 | TRP2RAN binding protein 2-HPRD10601307 
RANBP3DKFZp586I1520RAN binding protein 3-HPRD,BioGRID11425870 
RCC1CHC1 | RCC1-Iregulator of chromosome condensation 1-HPRD,BioGRID11932251 
RPS6KB1PS6K | S6K | S6K1 | STK14A | p70(S6K)-alpha | p70-S6K | p70-alpharibosomal protein S6 kinase, 70kDa, polypeptide 1Affinity Capture-WesternBioGRID16895915 
SMAD1BSP1 | JV4-1 | JV41 | MADH1 | MADR1SMAD family member 1-HPRD12519765 
SMARCB1BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFSSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1-HPRD,BioGRID11782423 
SMURF1KIAA1625SMAD specific E3 ubiquitin protein ligase 1-HPRD12519765 
SNUPNKPNBL | RNUT1 | Snurportin1snurportin 1-HPRD,BioGRID10209022 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDa-HPRD9205132 
TNFSF12-TNFSF13TWE-PRILTNFSF12-TNFSF13 readthrough transcript-HPRD11565755 
TNFSF13APRIL | CD256 | TALL2 | TRDL-1 | UNQ383/PRO715 | ligandtumor necrosis factor (ligand) superfamily, member 13Affinity Capture-WesternBioGRID11565755 
TOP2ATOP2 | TP2Atopoisomerase (DNA) II alpha 170kDa-HPRD12821127 
TOP2BTOPIIB | top2betatopoisomerase (DNA) II beta 180kDa-HPRD12821127 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA PTC1 PATHWAY 116All SZGR 2.0 genes in this pathway
PID HDAC CLASSII PATHWAY 3427All SZGR 2.0 genes in this pathway
PID NFKAPPAB CANONICAL PATHWAY 2320All SZGR 2.0 genes in this pathway
PID ILK PATHWAY 4532All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY 6650All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY 5447All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY 4943All SZGR 2.0 genes in this pathway
PID RANBP2 PATHWAY 1111All SZGR 2.0 genes in this pathway
PID HEDGEHOG GLI PATHWAY 4835All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY 8060All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421253All SZGR 2.0 genes in this pathway
REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 2313All SZGR 2.0 genes in this pathway
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 2616All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325185All SZGR 2.0 genes in this pathway
REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 158All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284128All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330155All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES 17298All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES 8150All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 8450All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION 192110All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA LIFE CYCLE 20372All SZGR 2.0 genes in this pathway
REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY 2719All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207122All SZGR 2.0 genes in this pathway
REACTOME HIV LIFE CYCLE 12569All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS 13281All SZGR 2.0 genes in this pathway
REACTOME LATE PHASE OF HIV LIFE CYCLE 10461All SZGR 2.0 genes in this pathway
REACTOME MITOTIC PROMETAPHASE 8751All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX 6342All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP 294178All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS UP 269146All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS YELLOW UP 3225All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP DN 199124All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228137All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536340All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL 11662All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855609All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483336All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514319All SZGR 2.0 genes in this pathway
MANN RESPONSE TO AMIFOSTINE DN 105All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414287All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK 168103All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
PUJANA BRCA CENTERED NETWORK 11772All SZGR 2.0 genes in this pathway
ALCALA APOPTOSIS 8860All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP 236139All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424268All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN 8151All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE DN 7652All SZGR 2.0 genes in this pathway
YAGI AML RELAPSE PROGNOSIS 3524All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337230All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
CROMER METASTASIS UP 7946All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH REARRANGEMENTS DN 4826All SZGR 2.0 genes in this pathway
YAGI AML SURVIVAL 12987All SZGR 2.0 genes in this pathway
KAMMINGA EZH2 TARGETS 4126All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D4 5537All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP 206118All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C2 5439All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN 312203All SZGR 2.0 genes in this pathway
GEISS RESPONSE TO DSRNA UP 3829All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 7 5134All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318220All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434302All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6 153112All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 8HR 3931All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425253All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294199All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163102All SZGR 2.0 genes in this pathway
HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE UP 7049All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN 185116All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356214All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518299All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP 188121All SZGR 2.0 genes in this pathway
WINNEPENNINCKX MELANOMA METASTASIS UP 16286All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335193All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570339All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP 11687All SZGR 2.0 genes in this pathway
BOUDOUKHA BOUND BY IGF2BP2 11159All SZGR 2.0 genes in this pathway
ABRAMSON INTERACT WITH AIRE 4533All SZGR 2.0 genes in this pathway