Found 109 literature records

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Entrez ID	Description
6794	Role of LKB1 as a master regulator of polarity and metabolism could contribute to its tumor suppressor function.
1050	"aberrant silencing, as well as, inappropriate cytoplasmic localization of C/EBPalpha causes dysregulation of its function, suggesting that C/EBPalpha is a novel candidate tumor suppressor gene in pancreatic cancer cells"
51684	human tumor suppressor SUFU has a role in Hedgehog signaling [review]
11184	Restoring wild-type HPK1 protein in pancreatic cancer cells led to the increase in p21 and p27 protein expression and cell cycle arrest. HPK1 may function as a novel tumor suppressor and its loss plays a critical role in pancreatic cancer.
4221	Decreased expression and promoter methylation of the menin tumor suppressor in pancreatic ductal adenocarcinoma.
9077	Expression of the tumor suppressor ARHI inhibits the growth of pancreatic cancer cells by inducing G1 cell cycle arrest.
51696	Human HECA slows down cell division of oral squamous cell carcinoma cells and may therefore act as a tumor suppressor in head and neck cancer.
5728	Data show that Protein levels of tumor suppressor targets of the miRNAs were increased by antisense to miR-21 (PTEN and RECK) and miR-221 (p27).
7057	The upregulation of both sst2 and TSP-1 tumor suppressors may function as an early negative feedback to restrain pancreatic carcinogenesis.
6850	Syk tyrosine kinase acts as a pancreatic adenocarcinoma tumor suppressor by regulating cellular growth and invasion.
857	Caveolin-1 acts as a tumor suppressor by down-regulating epidermal growth factor receptor-mitogen-activated protein kinase signaling pathway in pancreatic carcinoma cell lines.
56999	"The ADAMTS9 gene (ADAM metallopeptidase with thrombospondin type 1 motif, 9); has been characterized as a novel tumor suppressor gene in and epigenetically silenced in association with lymph node metastases in nasopharyngeal carcinoma."
406938	miR-146a suppresses invasion of pancreatic cancer cells.
4851	"Loss of Notch1 in this model resulted in increased tumor incidence and progression, implying that Notch1 can function as a tumor suppressor gene in PDAC."
406999	frequently downregulated miR-217 can regulate KRAS and function as a tumor suppressor in pancreatic ductal adenocarcinoma (PDAC).
1029	"Tumor suppressor p16 INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model."
27250	Tumor suppressor Pdcd4 is a major transcript that is upregulated during in vivo pancreatic islet neogenesis and is expressed in both beta-cell and ductal cell lines.
6711	"reduced SPTBN1 expression correlated with shorter survival of pancreatic cancer patients, suggesting a tumor suppressor function of this gene"
4221	The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization.
8125	Data provide evidence that the tumor suppressor function of pp32 can be attributed to its ability to disrupt HuR binding to target mRNAs encoding key proteins for cancer cell survival and drug efficacy.
9314	KLF4 is a novel candidate tumor suppressor gene in pancreatic ductal carcinoma.
10397	NDRG1 completely inhibits growth in anchorage-independent assays and in vivo supports a biological function as a tumor suppressor in pancreatic cancer.
51100	The expression of Bif-1 is downregulated in a subset of pancreatic ductal adenocarcinoma. This novel finding is in agreement with the tumor suppressor function of Bif-1.
675	Context dependence of checkpoint kinase 1 as a therapeutic target for pancreatic cancers deficient in the BRCA2 tumor suppressor.
7157	Context dependence of checkpoint kinase 1 as a therapeutic target for pancreatic cancers deficient in the BRCA2 tumor suppressor.
2048	"at least in the context of pancreatic carcinoma CFPAC-1 cells, EphB2 plays a tumor suppressor role in cell proliferation and apoptosis"
5925	miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor.
9046	Mutational analysis of DOK2 tumor suppressor gene in acute leukemias.
94241	This novel TP53INP1 activity on the regulation of SPARC expression could explain in part its tumor suppressor function in pancreatic adenocarcinoma by modulating cellular spreading during the metastatic process
5909	The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma.
9365	KL1 internal repeat mediates klotho tumor suppressor activities and inhibits bFGF and IGF-I signaling in pancreatic cancer.
406942	findings establish miR-150 as a novel regulator of MUC4 and a tumor suppressor miRNA in pancreatic cancer
1029	Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells.
4089	A restricted spectrum of mutations in the SMAD4 tumor-suppressor gene underlies Myhre syndrome.
8665	findings established a new mechanism of rRNA decay regulation mediated by hnRNP K/eIF3f and suggest that the tumor suppressive function of eIF3f may link to impaired rRNA degradation and translation
26585	Our data support a tumor suppressor role of GREM1 in pancreatic neuroendocrine tumors.
26471	"NUPR1 negatively regulates autophagy-mediated cell death via AURKA, in line with the idea of a tumor suppressor role of autophagy in cancer."
406929	miR-138 acts as a tumor suppressor and may prevent metastasis.
6665	Results indicate that the expression of SOX15 in pancreatic cancer cell lines with undetectable expression resulted in reduced viability of cancer cells both in vitro and in vivo demonstrating its tumor suppressive capability.
6498	These data strongly suggest that SnoN can function as a tumor suppressor at early stages of tumorigenesis in human cancer tissues.
5579	established an important role for PKCbeta1 in PANC1 cells suggesting it would act as a suppressor of tumorigenic behavior in pancreatic cancer
1788	provide evidence that Dnmt3a and Dnmt3b function as tumor suppressor genes in the prevention of lymphoid malignancies in mice.
1528	Results define CYB5A as a novel prognostic factor for PDAC that exerts its tumor-suppressor function through autophagy induction and TRAF6 modulation.
6387	"These data demonstrate a functional tumor suppressive role for the normal expression of CXCL12 in pancreatic ducts, regulating both tumor growth andcellulardissemination to metastatic sites."
407002	these results identify miR-219-1-3p as a new negative regulator of MUC4 oncomucin that possesses tumor-suppressor activity in Pancreatic ductal adenocarcinoma
23612	Data indicate that tumor suppressor PHLDA3-deficient mice develop islet hyperplasia.
23612	Results indicate that tumor suppressor PHLDA3-mediated pathway is important in the development of pancreatic neuroendocrine tumors (PanNETs).
406925	The results demonstrate that miR-135a targets Bmi1 in pancreatic ductal adenocarcinoma and functions as a tumor suppressor.
406926	The results demonstrate that miR-135a targets Bmi1 in pancreatic ductal adenocarcinoma and functions as a tumor suppressor.
4221	Inhibition of proliferation by K-RAS depended on antiproliferative RAS effector RASSF1A and blockade of the RAS-activated proproliferative RAF/MAPK pathway by tumor suppressor menin

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