Group: CMGC
Parent of:
CDK, CDKL, RCK, CLK, DYRK, GSK, MAPK, SRPK,
Description:
Group named after member families CDK, MAPK, GSK3 and CLK
Kinase with G-loop mutations in Group:CMGC
Uniprot ID |
Gene symbol |
Gatekeeper location |
G loop location |
A loop location |
αC-Helix location |
P06493 | CDK1 | 80 | 145...168 | 10...19 | 40...42 |
Q9NYV4 | CDK12 | 813 | 876...888, 890...900 | 733...739 | 769...778 |
Q14004 | CDK13 | 791 | 854...866, 868...878 | 711...717 | 747...758 |
Q00536 | CDK16 | 240 | 303...326 | 171...177 | 206...217 |
P24941 | CDK2 | 80 | 144...167 | 10...16 | 46...54 |
Q00535 | CDK5 | 80 | 143...166 | 10...16 | 46...55 |
Q00534 | CDK6 | 98 | 162...184 | 20...27 | 58...70 |
P50613 | CDK7 | 91 | 154...165, 167...177 | 19...26 | 58...68 |
Q92772 | CDKL2 | 80 | 143...166 | 7...18 | 10...13 |
Q8IVW4 | CDKL3 | 79 | 142...165 | 11...18 | 45...56 |
P49759 | CLK1 | [N/A] | [N/A] | 168...175 | 197...216 |
P49760 | CLK2 | 243 | 326...346 | 170...177 | 199...218 |
P49761 | CLK3 | [N/A] | [N/A] | 311...318 | 340...359 |
Q13627 | DYRK1A | 238 | 306...326 | 166...173 | 194...212 |
Q92630 | DYRK2 | 301 | 367...387 | 229...236 | 257...274 |
P28482 | MAPK1 | 110 | 166...192 | 32...39 | 62...77 |
P53779 | MAPK10 | 146 | 206...216, 220...228 | 67...79 | 98...100 |
O15264 | MAPK13 | 107 | 167...187 | 31...37 | 63...78 |
Q16539 | MAPK14 | [N/A] | [N/A] | 27...40 | 31...33 |
P27361 | MAPK3 | 122 | 183...209 | 49...56 | 79...94 |
Q16659 | MAPK6 | 113 | 170...196 | 23...36 | 56...70 |
Q13164 | MAPK7 | 137 | 199...226 | 62...69 | 93...108 |
P45983 | MAPK8 | 108 | 168...178, 182...190 | 32...38 | 60...62 |
P45984 | MAPK9 | [N/A] | [N/A] | 31...40 | 64...79 |