Group: CMGC
Parent of:
CDK, CDKL, RCK, CLK, DYRK, GSK, MAPK, SRPK,
Description:
Group named after member families CDK, MAPK, GSK3 and CLK
Kinase with mutated hotspots in Group:CMGC
Uniprot ID |
Gene symbol |
Gatekeeper location |
G loop location |
A loop location |
αC-Helix location |
P06493 | CDK1 | 80 | 145...168 | 10...19 | 40...42 |
Q15131 | CDK10 | 117 | 180...191, 193...203 | [N/A] | [N/A] |
Q9UQ88 | CDK11A | 504 | 567...578, 580...590 | [N/A] | [N/A] |
Q9NYV4 | CDK12 | 813 | 876...888, 890...900 | 733...739 | 769...778 |
Q14004 | CDK13 | 791 | 854...866, 868...878 | 711...717 | 747...758 |
O94921 | CDK14 | 210 | 273...296 | [N/A] | [N/A] |
Q00536 | CDK16 | 240 | 303...326 | 171...177 | 206...217 |
Q9BWU1 | CDK19 | [N/A] | 172...198 | [N/A] | [N/A] |
P24941 | CDK2 | 80 | 144...167 | 10...16 | 46...54 |
Q8IZL9 | CDK20 | 81 | 144...155, 160...168 | [N/A] | [N/A] |
Q00526 | CDK3 | 80 | 144...167 | [N/A] | [N/A] |
P11802 | CDK4 | 93 | [N/A] | [N/A] | 51...63 |
Q00535 | CDK5 | 80 | 143...166 | 10...16 | 46...55 |
Q00534 | CDK6 | 98 | 162...184 | 20...27 | 58...70 |
P50613 | CDK7 | 91 | 154...165, 167...177 | 19...26 | 58...68 |
P49336 | CDK8 | 97 | 172...198 | [N/A] | 61...72 |
P50750 | CDK9 | 103 | 166...180, 183...193 | [N/A] | 61...72 |
Q92772 | CDKL2 | 80 | 143...166 | 7...18 | 10...13 |
Q8IVW4 | CDKL3 | 79 | 142...165 | 11...18 | 45...56 |
O76039 | CDKL5 | 89 | 152...176 | [N/A] | 55...66 |
P49759 | CLK1 | [N/A] | [N/A] | 168...175 | 197...216 |
P49760 | CLK2 | 243 | 326...346 | 170...177 | 199...218 |
P49761 | CLK3 | [N/A] | [N/A] | 311...318 | 340...359 |
Q9HAZ1 | CLK4 | 239 | 322...342 | [N/A] | [N/A] |
Q13627 | DYRK1A | 238 | 306...326 | 166...173 | 194...212 |
Q9Y463 | DYRK1B | 190 | 258...278 | [N/A] | [N/A] |
Q92630 | DYRK2 | 301 | 367...387 | 229...236 | 257...274 |
O43781 | DYRK3 | 288 | 354...374 | [N/A] | [N/A] |
Q9NR20 | DYRK4 | 183 | 249...269 | [N/A] | [N/A] |
P49840 | GSK3A | 195 | 262...272, 274...284 | [N/A] | [N/A] |
P49841 | GSK3B | [N/A] | [N/A] | [N/A] | 96...102 |
Q9H422 | HIPK3 | 275 | 343...364 | [N/A] | [N/A] |
Q8NE63 | HIPK4 | 89 | [N/A] | [N/A] | [N/A] |
Q9UPZ9 | CILK1 | 79 | 142...152, 155...164 | [N/A] | [N/A] |
P20794 | MAK | 79 | 142...152, 155...164 | [N/A] | [N/A] |
P28482 | MAPK1 | 110 | 166...192 | 32...39 | 62...77 |
P53779 | MAPK10 | 146 | 206...216, 220...228 | 67...79 | 98...100 |
Q15759 | MAPK11 | 106 | [N/A] | [N/A] | 62...77 |
P53778 | MAPK12 | 114 | 170...190 | [N/A] | 65...80 |
O15264 | MAPK13 | 107 | 167...187 | 31...37 | 63...78 |
Q16539 | MAPK14 | [N/A] | [N/A] | 27...40 | 31...33 |
Q8TD08 | MAPK15 | 92 | 154...166, 173...182 | [N/A] | [N/A] |
P27361 | MAPK3 | 122 | 183...209 | 49...56 | 79...94 |
P31152 | MAPK4 | 110 | 167...193 | [N/A] | [N/A] |
Q16659 | MAPK6 | 113 | 170...196 | 23...36 | 56...70 |
Q13164 | MAPK7 | 137 | 199...226 | 62...69 | 93...108 |
P45983 | MAPK8 | 108 | 168...178, 182...190 | 32...38 | 60...62 |
P45984 | MAPK9 | [N/A] | [N/A] | 31...40 | 64...79 |
Q9UQ07 | MOK | 82 | 144...166 | [N/A] | [N/A] |
Q9UBE8 | NLK | 219 | 281...305 | [N/A] | [N/A] |
Q13523 | PRPF4B | 767 | 833...854 | [N/A] | 707...709 |
Q96SB4 | SRPK1 | 165 | 496...516 | [N/A] | 115...133 |
P78362 | SRPK2 | 166 | [N/A] | [N/A] | 116...134 |