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Dataset Description
  • Dataset Name: 16292326
  • Species: Human
  • Method: Microarray
  • No. of Genes: 303
  • Tissue: Frontal cortex
  • Phenotype: Alcohol dependence (AD)/Alcohol abuse/Alcoholism
  • Publication: Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
  • Dataset Summary: In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

    Gene list of this dataset (303 genes)
    Page: 1 2 3 4 5 6 7 list all   
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    5354PLP1proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)Xq22Hs.1787 
    5376PMP22peripheral myelin protein 2217p12-p11.2Hs.372031 
    54462KIAA1128KIAA112810q23.1Hs.461988 
    54463FAM134Bfamily with sequence similarity 134, member B5p15.1Hs.481704 
    5464PPA1pyrophosphatase (inorganic) 110q11.1-q24Hs.437403 
    54933RHBDL2rhomboid, veinlet-like 2 (Drosophila)1p34.3Hs.524626 
    5495PPM1Bprotein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform2p21Hs.416769 
    5516PPP2CBprotein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform8p12Hs.491440 
    55325UFSP2UFM1-specific peptidase 24q35.1Hs.508154 
    55331PHCAphytoceramidase, alkaline11q13.5Hs.23862 
    55619DOCK10dedicator of cytokinesis 102q36.2Hs.46578 
    55704CCDC88Acoiled-coil domain containing 88A2p16.1Hs.292925 
    55746NUP133nucleoporin 133kDa1q42.13Hs.12457 
    55788LMBRD1LMBR1 domain containing 16q13Hs.271643 
    55819RNF130ring finger protein 1305q35.3Hs.484363 
    55852TEX2testis expressed 217q23.3Hs.175414 
    55858TMEM165transmembrane protein 1654q12Hs.479766 
    5638PRRG1proline rich Gla (G-carboxyglutamic acid) 1Xp21.1Hs.190341 
    56907SPIRE1spire homolog 1 (Drosophila)18p11.21Hs.515283 
    5690PSMB2proteasome (prosome, macropain) subunit, beta type, 21p34.2Hs.471441 
    56987BBXbobby sox homolog (Drosophila)3q13.1Hs.124366 
    57018CCNL1cyclin L13q25.32Hs.4859 
    57035C1orf63chromosome 1 open reading frame 631p36.13-p35.1Hs.259412 
    57185NPAL3NIPA-like domain containing 31p36.12-p35.1Hs.523442 
    57448BIRC6baculoviral IAP repeat-containing 6 (apollon)2p22-p21Hs.150107 
    57478USP31ubiquitin specific peptidase 3116p12.1Hs.183817 
    57509MTUS1mitochondrial tumor suppressor 18p22Hs.7946 
    57515SERINC1serine incorporator 16q22.31Hs.146668 
    57674RNF213ring finger protein 21317q25.3Hs.195642 
    5962RDXradixin11q23Hs.263671 
    5981RFC1replication factor C (activator 1) 1, 145kDa4p14-p13Hs.507475 
    60481ELOVL5ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)6p21.1-p12.1Hs.520189 
    6195RPS6KA1ribosomal protein S6 kinase, 90kDa, polypeptide 11pHs.149957 
    6242RTKNrhotekin2p13.1Hs.192854 
    6421SFPQsplicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)1p34.3Hs.355934 
    6443SGCBsarcoglycan, beta (43kDa dystrophin-associated glycoprotein)4q12Hs.438953 
    6558SLC12A2solute carrier family 12 (sodium/potassium/chloride transporters), member 25q23.3Hs.162585 
    65981CAPRIN2caprin family member 212p11Hs.234355 
    6683SPASTspastin2p24-p21Hs.468091 
    6733SRPK2SFRS protein kinase 27q22-q31.1Hs.285197 
    6785ELOVL4elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 46q14Hs.101915 
    6845VAMP7vesicle-associated membrane protein 7Xq28 and Yq12Hs.24167 
    6867TACC1transforming, acidic coiled-coil containing protein 18p11Hs.279245 
    687KLF9Kruppel-like factor 99q13Hs.150557 
    6938TCF12transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)15q21Hs.511504 
    7018TFtransferrin3q22.1Hs.518267 
    7042TGFB2transforming growth factor, beta 21q41Hs.133379 
    7086TKTtransketolase (Wernicke-Korsakoff syndrome)3p14.3Hs.89643 
    7368UGT8UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase)4q26Hs.144197 
    745C11orf9chromosome 11 open reading frame 911q12-q13.1Hs.473109 
    Page: 1 2 3 4 5 6 7 list all