SZGR2

Summary ?

GeneID	3480
Symbol	IGF1R
Synonyms	CD221\|IGFIR\|IGFR\|JTK13
Description	insulin like growth factor 1 receptor
Reference	MIM:147370\|HGNC:HGNC:5465\|Ensembl:ENSG00000140443\|HPRD:00932\|Vega:OTTHUMG00000149851
Gene type	protein-coding
Map location	15q26.3
Pascal p-value	0.125
Sherlock p-value	0.037
Fetal beta	2.226
DMG	1 (# studies)
eGene	Cerebellar Hemisphere Cerebellum Myers' cis & trans Meta
Support	Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenics,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0073

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg10507754	15	99504358	IGF1R	2.957E-4	0.319	0.039	DMG:Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs4965530	chr15	98720317	IGF1R	3480		0.2		cis

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0005010	insulin-like growth factor receptor activity	IDA		7679099
GO:0004872	receptor activity	IEA		-
GO:0005158	insulin receptor binding	IDA		8452530
GO:0005524	ATP binding	IEA		-
GO:0004713	protein tyrosine kinase activity	IEA		-
GO:0016740	transferase activity	IEA		-
GO:0042802	identical protein binding	IPI		11448933
GO:0031994	insulin-like growth factor I binding	IPI		8452530
GO:0043548	phosphoinositide 3-kinase binding	IPI		7541045
GO:0043559	insulin binding	IPI		8452530
GO:0043560	insulin receptor substrate binding	IPI		7541045
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007420	brain development	IEA	Brain (GO term level: 7)	-
GO:0030238	male sex determination	IEA		-
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0009887	organ morphogenesis	IEA		-
GO:0007165	signal transduction	TAS		3003744
GO:0008284	positive regulation of cell proliferation	TAS		10749889
GO:0008286	insulin receptor signaling pathway	TAS		10829031
GO:0048015	phosphoinositide-mediated signaling	IDA		7692086
GO:0048009	insulin-like growth factor receptor signaling pathway	IDA		7679099
GO:0006955	immune response	IMP		16886151
GO:0006916	anti-apoptosis	TAS		8710868
GO:0014065	phosphoinositide 3-kinase cascade	IC		7541045
GO:0051262	protein tetramerization	IDA		1846292
GO:0030335	positive regulation of cell migration	IMP		12138094
GO:0045740	positive regulation of DNA replication	IMP		12138094
GO:0046777	protein amino acid autophosphorylation	IDA		1846292 \|7679099 \|11162456
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005792	microsome	IDA		8452530
GO:0016020	membrane	IEA		-
GO:0005887	integral to plasma membrane	IC		7679099

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARHGEF12	DKFZp686O2372 \| KIAA0382 \| LARG \| PRO2792	Rho guanine nucleotide exchange factor (GEF) 12	-	HPRD,BioGRID	11724822
CSK	MGC117393	c-src tyrosine kinase	CSK interacts with IGF-IR.	BIND	10026153
CSK	MGC117393	c-src tyrosine kinase	-	HPRD,BioGRID	10026153
DOK5	C20orf180 \| MGC16926	docking protein 5	-	HPRD	12730241
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	Affinity Capture-Western	BioGRID	17047074
EHD1	FLJ42622 \| FLJ44618 \| H-PAST \| HPAST1 \| PAST \| PAST1	EH-domain containing 1	-	HPRD,BioGRID	11423532
EHD1	FLJ42622 \| FLJ44618 \| H-PAST \| HPAST1 \| PAST \| PAST1	EH-domain containing 1	EHD1 interacts with IGF-1R.	BIND	11423532
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	Affinity Capture-Western	BioGRID	16113100
GIGYF1	GYF1 \| PERQ1	GRB10 interacting GYF protein 1	-	HPRD	12771153
GNAI1	Gi	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	-	HPRD,BioGRID	10644671
GNAI2	GIP \| GNAI2B \| H_LUCA15.1 \| H_LUCA16.1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	-	HPRD	11120746
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	IGF-IR interacts with RACK1.	BIND	11884618
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	-	HPRD,BioGRID	11884618
GRB10	GRB-IR \| Grb-10 \| IRBP \| KIAA0207 \| MEG1 \| RSS	growth factor receptor-bound protein 10	-	HPRD	8621530 \|8764099
GRB10	GRB-IR \| Grb-10 \| IRBP \| KIAA0207 \| MEG1 \| RSS	growth factor receptor-bound protein 10	Grb10 interacts with IGFIR.	BIND	9506989
GRB10	GRB-IR \| Grb-10 \| IRBP \| KIAA0207 \| MEG1 \| RSS	growth factor receptor-bound protein 10	Affinity Capture-Western in vitro in vivo Reconstituted Complex Two-hybrid	BioGRID	8764099 \|8776723 \|9506989 \|12697834
IGF1	IGFI	insulin-like growth factor 1 (somatomedin C)	IGF-I interacts with IGF-IR. This interaction was modeled on a demonstrated interaction between IGF-I from an unspecified species and human IGF-IR.	BIND	15604363
IGF1	IGFI	insulin-like growth factor 1 (somatomedin C)	-	HPRD,BioGRID	1852007
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	-	HPRD	12138114
IGF2	C11orf43 \| FLJ22066 \| FLJ44734 \| INSIGF \| pp9974	insulin-like growth factor 2 (somatomedin A)	-	HPRD,BioGRID	9972281
IGFBP3	BP-53 \| IBP3	insulin-like growth factor binding protein 3	-	HPRD,BioGRID	9389554
INS	ILPR \| IRDN	insulin	Insulin interacts with IGF-IR. This interaction was modeled on a demonstrated interaction between Insulin from an unspecified species and human IGF-IR.	BIND	15604363
INS	ILPR \| IRDN	insulin	-	HPRD	1851182
IRS1	HIRS-1	insulin receptor substrate 1	IGFIR interacts with IRS-1.	BIND	7541045
IRS1	HIRS-1	insulin receptor substrate 1	IRS-1 interacts with IGF-IR. This interaction was modeled on a demonstrated interaction between rat IRS-1 and human IGF-IR.	BIND	10026153
IRS1	HIRS-1	insulin receptor substrate 1	-	HPRD,BioGRID	7559507
IRS2	-	insulin receptor substrate 2	-	HPRD	9852124
IRS2	-	insulin receptor substrate 2	Insulin Receptor Substrate-2 Binds to the Insulin-like Growth Factor Receptor Beta subunit. This interaction is modeled on demonstrated interaction between human IGF-IR and murine IRS-2	BIND	8626379
ITGB1	CD29 \| FNRB \| GPIIA \| MDF2 \| MSK12 \| VLA-BETA \| VLAB	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	beta-1 integrin interacts with IGF-IR.	BIND	11884618
JAK1	JAK1A \| JAK1B \| JTK3	Janus kinase 1 (a protein tyrosine kinase)	Phosphorylated IGF-1R-beta interacts with JAK-1.	BIND	9492017
JAK1	JAK1A \| JAK1B \| JTK3	Janus kinase 1 (a protein tyrosine kinase)	-	HPRD,BioGRID	9492017
NAMPT	1110035O14Rik \| DKFZp666B131 \| MGC117256 \| PBEF \| PBEF1 \| VF \| VISFATIN	nicotinamide phosphoribosyltransferase	PBEF interacts with IGF-IR. This interaction was modeled on a demonstrated interaction between PBEF from an unspecified species and human IGF-IR.	BIND	15604363
NEDD4	KIAA0093 \| MGC176705 \| NEDD4-1 \| RPF1	neural precursor cell expressed, developmentally down-regulated 4	-	HPRD,BioGRID	12697834
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD,BioGRID	8697095
PIK3R2	P85B \| p85 \| p85-BETA	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	IGFIR interacts with p85. This interaction was modeled on a demonstrated interaction between rat proteins.	BIND	7541045
PIK3R3	DKFZp686P05226 \| FLJ41892 \| p55 \| p55-GAMMA	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	-	HPRD,BioGRID	9415396 \|9524259
PRKCD	MAY1 \| MGC49908 \| PKCD \| nPKC-delta	protein kinase C, delta	PKC-delta interacts with IGF-IR.	BIND	11884618
PRKD1	PKC-MU \| PKCM \| PKD \| PRKCM	protein kinase D1	PKC-mu interacts with IGF-IR.	BIND	11884618
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	Affinity Capture-Western	BioGRID	10082579
PTPN1	PTP1B	protein tyrosine phosphatase, non-receptor type 1	-	HPRD,BioGRID	8999839
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	-	HPRD,BioGRID	7642582
PXN	FLJ16691	paxillin	Affinity Capture-Western	BioGRID	10082579
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	-	HPRD,BioGRID	7642582
SHC1	FLJ26504 \| SHC \| SHCA	SHC (Src homology 2 domain containing) transforming protein 1	IGFIR interacts with SHC.	BIND	7541045
SHC1	FLJ26504 \| SHC \| SHCA	SHC (Src homology 2 domain containing) transforming protein 1	-	HPRD,BioGRID	8776723
SNAP29	CEDNIK \| FLJ21051 \| SNAP-29	synaptosomal-associated protein, 29kDa	-	HPRD,BioGRID	11423532
SOCS1	CIS1 \| CISH1 \| JAB \| SOCS-1 \| SSI-1 \| SSI1 \| TIP3	suppressor of cytokine signaling 1	-	HPRD,BioGRID	9727029
SOCS1	CIS1 \| CISH1 \| JAB \| SOCS-1 \| SSI-1 \| SSI1 \| TIP3	suppressor of cytokine signaling 1	Insulin-like Growth Factor-I Receptor interacts with SOCS1	BIND	9727029
SOCS2	CIS2 \| Cish2 \| SOCS-2 \| SSI-2 \| SSI2 \| STATI2	suppressor of cytokine signaling 2	Interaction of Human Suppressor of Cytokine Signaling (SOCS)-2 with the Insulin-like Growth Factor-I Receptor	BIND	9727029
SOCS2	CIS2 \| Cish2 \| SOCS-2 \| SSI-2 \| SSI2 \| STATI2	suppressor of cytokine signaling 2	-	HPRD,BioGRID	9727029
SOCS3	ATOD4 \| CIS3 \| Cish3 \| MGC71791 \| SOCS-3 \| SSI-3 \| SSI3	suppressor of cytokine signaling 3	Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor I receptor.	BIND	11071852
SOCS3	ATOD4 \| CIS3 \| Cish3 \| MGC71791 \| SOCS-3 \| SSI-3 \| SSI3	suppressor of cytokine signaling 3	in vitro in vivo	BioGRID	11071852
VAV3	FLJ40431	vav 3 guanine nucleotide exchange factor	-	HPRD,BioGRID	11094073
WISP2	CCN5 \| CT58 \| CTGF-L	WNT1 inducible signaling pathway protein 2	-	HPRD	10358067
YWHAB	GW128 \| HS1 \| KCIP-1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	-	HPRD,BioGRID	9581554
YWHAB	GW128 \| HS1 \| KCIP-1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	IGFIR interacts with 14-3-3-beta isoform. This interaction was modelled on a demonstrated interaction between human IGFIR and mouse 14-3-3-beta.	BIND	9581554
YWHAE	14-3-3E \| FLJ45465 \| KCIP-1 \| MDCR \| MDS	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	-	HPRD,BioGRID	9111084
YWHAE	14-3-3E \| FLJ45465 \| KCIP-1 \| MDCR \| MDS	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	IGFIR interacts with 14-3-3-epsilon isoform. This interaction is modeled on a demonstrated interaction between human IGFIR and mouse 14-3-3-epsilon isoform	BIND	9111084
YWHAG	14-3-3GAMMA	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	Affinity Capture-MS	BioGRID	17353931
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	-	HPRD	9581554
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	IGFIR interacts with 14-3-3-zeta isoform.	BIND	9581554

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG OOCYTE MEIOSIS	114	79	All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS	183	132	All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION	75	53	All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION	70	53	All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION	86	59	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG GLIOMA	65	56	All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER	89	75	All SZGR 2.0 genes in this pathway
KEGG MELANOMA	71	57	All SZGR 2.0 genes in this pathway
BIOCARTA HDAC PATHWAY	32	25	All SZGR 2.0 genes in this pathway
BIOCARTA ERK PATHWAY	28	22	All SZGR 2.0 genes in this pathway
BIOCARTA IGF1 PATHWAY	21	16	All SZGR 2.0 genes in this pathway
BIOCARTA IGF1R PATHWAY	23	20	All SZGR 2.0 genes in this pathway
BIOCARTA BAD PATHWAY	26	23	All SZGR 2.0 genes in this pathway
BIOCARTA IGF1MTOR PATHWAY	20	14	All SZGR 2.0 genes in this pathway
BIOCARTA TEL PATHWAY	18	15	All SZGR 2.0 genes in this pathway
BIOCARTA LONGEVITY PATHWAY	15	13	All SZGR 2.0 genes in this pathway
PID ER NONGENOMIC PATHWAY	41	35	All SZGR 2.0 genes in this pathway
PID SHP2 PATHWAY	58	46	All SZGR 2.0 genes in this pathway
PID IGF1 PATHWAY	30	23	All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY	48	38	All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY	75	53	All SZGR 2.0 genes in this pathway
PID ECADHERIN STABILIZATION PATHWAY	42	34	All SZGR 2.0 genes in this pathway
WATANABE COLON CANCER MSI VS MSS DN	81	42	All SZGR 2.0 genes in this pathway
WILCOX RESPONSE TO PROGESTERONE DN	66	44	All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP	276	187	All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL UP	133	78	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
BERENJENO ROCK SIGNALING NOT VIA RHOA DN	48	34	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 UP	121	71	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN	229	142	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN	228	137	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
BARIS THYROID CANCER DN	59	45	All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS	1174	695	All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS	355	243	All SZGR 2.0 genes in this pathway
PEREZ TP53 AND TP63 TARGETS	205	145	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 XPCS DN	88	71	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL	326	213	All SZGR 2.0 genes in this pathway
LI CISPLATIN RESISTANCE UP	28	20	All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM UP	81	57	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 2 DN	51	42	All SZGR 2.0 genes in this pathway
SIMBULAN UV RESPONSE IMMORTALIZED DN	31	26	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS UP	127	79	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP	283	177	All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION UP	195	138	All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215	893	528	All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER DN	36	24	All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 7	27	22	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 15Q26 AMPLICON	22	19	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
BECKER TAMOXIFEN RESISTANCE DN	52	37	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
GUO HEX TARGETS UP	81	54	All SZGR 2.0 genes in this pathway
NGUYEN NOTCH1 TARGETS DN	86	67	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM	302	191	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD DN	150	93	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN	215	132	All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR DN	53	40	All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR DN	91	64	All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND TBH	60	42	All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN	128	93	All SZGR 2.0 genes in this pathway
GENTILE UV LOW DOSE DN	67	46	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1	528	324	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4	307	185	All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER T4	94	69	All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN	220	147	All SZGR 2.0 genes in this pathway
AMUNDSON GAMMA RADIATION RESISTANCE	20	14	All SZGR 2.0 genes in this pathway
FINETTI BREAST CANCERS KINOME BLUE	21	16	All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN	258	160	All SZGR 2.0 genes in this pathway
MASSARWEH RESPONSE TO ESTRADIOL	61	47	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP	210	124	All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA E2	118	65	All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN	940	425	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN	701	446	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN	175	103	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN	252	155	All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION C	69	49	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN	457	302	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN	668	419	All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN	134	83	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 1	68	50	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR UP	61	44	All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN	157	106	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP	504	321	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B	549	316	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE	317	190	All SZGR 2.0 genes in this pathway
BAKKER FOXO3 TARGETS UP	61	41	All SZGR 2.0 genes in this pathway
DELPUECH FOXO3 TARGETS UP	68	49	All SZGR 2.0 genes in this pathway
FARDIN HYPOXIA 11	32	29	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
SERVITJA ISLET HNF1A TARGETS DN	109	71	All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP	279	155	All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF	222	159	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY	1839	928	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	2619	2626	1A,m8	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
				hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-122	1347	1353	1A	hsa-miR-122a	UGGAGUGUGACAAUGGUGUUUGU
miR-143	2664	2670	1A	hsa-miR-143^brain	UGAGAUGAAGCACUGUAGCUCA
miR-145	3804	3810	m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-15/16/195/424/497	3502	3508	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
				hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-153	188	194	1A	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-182	586	593	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-182	586	593	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-194	6813	6819	1A	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-214	1870	1876	1A	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-217	152	158	1A	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-223	224	231	1A,m8	hsa-miR-223	UGUCAGUUUGUCAAAUACCCC
miR-30-5p	5798	5804	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
				hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-320	196	202	m8	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-320	196	202	m8	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-326	5069	5075	1A	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-363	5748	5754	1A	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-376	1307	1314	1A,m8	hsa-miR-376a	AUCAUAGAGGAAAAUCCACGU
miR-376	1307	1314	1A,m8	hsa-miR-376b	AUCAUAGAGGAAAAUCCAUGUU
miR-376c	1162	1168	m8	hsa-miR-376c	AACAUAGAGGAAAUUCCACG
miR-378*	5589	5595	m8	hsa-miR-422b	CUGGACUUGGAGUCAGAAGGCC
miR-378*	5589	5595	m8	hsa-miR-422a	CUGGACUUAGGGUCAGAAGGCC
miR-381	6905	6911	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-409-5p	2706	2712	m8	hsa-miR-409-5p	AGGUUACCCGAGCAACUUUGCA
miR-410	6863	6869	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-421	4195	4201	1A	hsa-miR-421	GGCCUCAUUAAAUGUUUGUUG
miR-448	187	194	1A,m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-455	3782	3788	1A	hsa-miR-455	UAUGUGCCUUUGGACUACAUCG
miR-494	5648	5655	1A,m8	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-495	6811	6817	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-503	1269	1275	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-93.hd/291-3p/294/295/302/372/373/520	2211	2217	m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU
miR-96	5822	5828	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC
miR-96	5822	5828	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC
miR-99/100	5602	5609	1A,m8	hsa-miR-99a^brain	AACCCGUAGAUCCGAUCUUGUG
				hsa-miR-100^brain	AACCCGUAGAUCCGAACUUGUG
				hsa-miR-99b^brain	CACCCGUAGAACCGACCUUGCG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: IGF1R