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Dataset Description
  • Dataset Name: 17295719
  • Species: Mouse
  • Method: Microarray
  • No. of Genes: 115
  • Tissue: Cultured fetal mouse cortical neurons
  • Phenotype: Ethanol response
  • Publication: Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
  • Dataset Summary: By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

    Gene list of this dataset (115 genes)
    Page: 1 2 3 list all   
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    19158Pscd2pleckstrin homology, Sec7 and coiled-coil domains 27 B4Pscd2 
    19244Ptp4a2protein tyrosine phosphatase 4a24 D2.3Ptp4a2 
    69908Rab3bRAB3B, member RAS oncogene family4 C7Rab3b 
    19342Rab4bRAB4B, member RAS oncogene family7 A3|7 7.4 cMRab4b 
    19744RhebRAS-homolog enriched in brain5 A3Rheb 
    19877Rock1Rho-associated coiled-coil containing protein kinase 118 A2Rock1 
    21926Tnftumor necrosis factor17 B1|17 19.06 cMTnf 
    17765Mtf2metal response element binding transcription factor 25 FMtf2 
    18515Pbx2pre B-cell leukemia transcription factor 217 B1Pbx2 
    21425Tcfebtranscription factor EB17 D|17 26.0 cMTcfeb 
    11941Atp2b2ATPase, Ca++ transporting, plasma membrane 26 E3|6 49.5 cMAtp2b2 
    53872Caprin1cell cycle associated protein 12 E2Gpiap1 
    15567Slc6a4solute carrier family 6 (neurotransmitter transporter, serotonin), member 411 B5|11 42.0 cMSlc6a4 
    71375Foxn3forkhead box N312 F1BC029185 
    216873Spag7sperm associated antigen 711 B4|11 42.0 cMSpag7 
    12531Cdc25bcell division cycle 25 homolog B (S. pombe)2 F1|2 73.9 cMCdc25b 
    245688Rbbp7retinoblastoma binding protein 7X F4Rbbp7 
    11501Adam8a disintegrin and metallopeptidase domain 87 F3-F5Adam8 
    100043024Tnxatenascin XA17 B1Tnxa 
    14433Gapdhglyceraldehyde-3-phosphate dehydrogenase6 F2Gapd 
        M27315 
    18746Pkm2pyruvate kinase, muscle9 B|9 52.0 cMPk3 
    20656Sod2superoxide dismutase 2, mitochondrial17 A1|17 7.6 cMSod2 
    14805Grik1glutamate receptor, ionotropic, kainate 116 C3.3|16 58.0 cMGrik1 
    319504Nrcamneuron-glia-CAM-related cell adhesion molecule12 B3Nrcam 
    18196Nsg1neuron specific gene family member 15 B3|5 21.0 cMNsg1 
        Prosap1 
    64051Sv2asynaptic vesicle glycoprotein 2 a3 F2Sv2a 
    20977SypsynaptophysinX A-D|X 1.5 cMSyp 
    12461Cct2chaperonin subunit 2 (beta)10 D2Cct2 
    19167Psma3proteasome (prosome, macropain) subunit, alpha type 312 C3Psma3 
    26441Psma4proteasome (prosome, macropain) subunit, alpha type 49 CPsma4 
    26442Psma5proteasome (prosome, macropain) subunit, alpha type 53 F3Psma5 
    19172Psmb4proteasome (prosome, macropain) subunit, beta type 43 F2|3 43.1 cMPsmb4 
    70247Psmd1proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 C5Psmd1 
    22200Uba3ubiquitin-like modifier activating enzyme 36 D3Ube1c 
    22258Usp4ubiquitin specific peptidase 4 (proto-oncogene)9 F2|9 60.0 cMUsp4 
    22284Usp9xubiquitin specific peptidase 9, X chromosomeX A1.1|X 5.5 cMUsp9x 
    60441Mrpl38mitochondrial ribosomal protein L3811 E2Mrpl38 
    19942Rpl27ribosomal protein L2711 A1Rpl27 
    26961Rpl8ribosomal protein L815 E1Rpl8 
    20091Rps3aribosomal protein S3a3 F1Rps3a 
    11512Adcy6adenylate cyclase 615 FAdcy6 
    11550Adra1dadrenergic receptor, alpha 1d2 F1|2 74.9 cMAdra1d 
    11652Akt2thymoma viral proto-oncogene 27 B1|7 6.5 cMAkt2 
    11841Arf2ADP-ribosylation factor 211 E1|11 62.0 cMArf2 
    11852Rhobras homolog gene family, member B12 A1.1Arhb 
    19055Ppp3caprotein phosphatase 3, catalytic subunit, alpha isoform3 G3Calna 
    52163Camk1calcium/calmodulin-dependent protein kinase I6 E3|6 48.7 cMCamk1 
    23991Cib1calcium and integrin binding 1 (calmyrin)7 D3Cib1 
    Page: 1 2 3 list all