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Dataset Description
  • Dataset Name: 17295719
  • Species: Mouse
  • Method: Microarray
  • No. of Genes: 115
  • Tissue: Cultured fetal mouse cortical neurons
  • Phenotype: Ethanol response
  • Publication: Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
  • Dataset Summary: By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

    Gene list of this dataset (115 genes)
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    12539Cdc37cell division cycle 37 homolog (S. cerevisiae)9 A3Cdc37 
    12540Cdc42cell division cycle 42 homolog (S. cerevisiae)4 D3|4 66.75 cMCdc42 
    51788H2afzH2A histone family, member Z3 G3H2afz 
    245688Rbbp7retinoblastoma binding protein 7X F4Rbbp7 
    109711Actn1actinin, alpha 112 C3|12 35.0 cMActn1 
    11502Adam9a disintegrin and metallopeptidase domain 9 (meltrin gamma)8 A2|8 8.0 cMAdam9 
    11804Aplp2amyloid beta (A4) precursor-like protein 29 A2-B|9 13.0 cMAplp2 
    22142Tuba1atubulin, alpha 1A15 F1|15 60.4 cMTuba1 
    17711CYTBcytochrome b, mitochondrial-Cytb 
    14104Fasnfatty acid synthase11 E2|11 72.0 cMFasn 
    140483Hnmthistamine N-methyltransferase2 A3Hnmt 
    18746Pkm2pyruvate kinase, muscle9 B|9 52.0 cMPk3 
    20656Sod2superoxide dismutase 2, mitochondrial17 A1|17 7.6 cMSod2 
    54393Gabbr1gamma-aminobutyric acid (GABA-B) receptor, 117 B1|17 20.4 cMGababr1 
    14800Gria2glutamate receptor, ionotropic, AMPA2 (alpha 2)3 E3|3 33.6 cMGria2 
    18196Nsg1neuron specific gene family member 15 B3|5 21.0 cMNsg1 
    18546Pcp4Purkinje cell protein 416 C4|16 69.9 cMPcp4 
        Prosap1 
    20977SypsynaptophysinX A-D|X 1.5 cMSyp 
    15511Hspa1bheat shock protein 1B17 B1|17 18.9 cMHsp70 
    15516Hsp90ab1heat shock protein 90kDa alpha (cytosolic), class B member 117 B3|17 15.0 cMHsp84 
    15481Hspa8heat shock protein 89 A5.1|9 24.0 cMHspa8 
    19172Psmb4proteasome (prosome, macropain) subunit, beta type 43 F2|3 43.1 cMPsmb4 
    19184Psmc5protease (prosome, macropain) 26S subunit, ATPase 511 E1Psmc5 
    22258Usp4ubiquitin specific peptidase 4 (proto-oncogene)9 F2|9 60.0 cMUsp4 
    22284Usp9xubiquitin specific peptidase 9, X chromosomeX A1.1|X 5.5 cMUsp9x 
    26961Rpl8ribosomal protein L815 E1Rpl8 
    20103Rps5ribosomal protein S57 A1Rps5 
    11350Abl1c-abl oncogene 1, receptor tyrosine kinase2 B|2 21.0 cMAbl1 
    11652Akt2thymoma viral proto-oncogene 27 B1|7 6.5 cMAkt2 
    19055Ppp3caprotein phosphatase 3, catalytic subunit, alpha isoform3 G3Calna 
    52163Camk1calcium/calmodulin-dependent protein kinase I6 E3|6 48.7 cMCamk1 
    56431Dstndestrin2 H1|2 81.4 cMDstn 
    15200Hbegfheparin-binding EGF-like growth factor18 B2|18 15.0 cMDtr 
    14365Fzd3frizzled homolog 3 (Drosophila)14 D1|14 27.0 cMFzd3 
    14693Gnb2guanine nucleotide binding protein (G protein), beta 25 G2|5 76.0 cMGnb2 
    56637Gsk3bglycogen synthase kinase 3 beta16 B4Gsk3b 
    227753Gsngelsolin2 B|2 24.5 cMGsn 
    26395Map2k1mitogen-activated protein kinase kinase 19 C|9 36.0 cMMap2k1 
    26406Map3k3mitogen-activated protein kinase kinase kinase 311 E1Map3k3 
    26417Mapk3mitogen-activated protein kinase 37 F3|7 61.0 cMMapk3 
    17118Marcksmyristoylated alanine rich protein kinase C substrate10 B1|10 22.0 cMMarcks 
    17330Minpp1multiple inositol polyphosphate histidine phosphatase 119 C1|19 35.0 cMMinpp1 
        Mustcratf 
    18049Ngfnerve growth factor3 F2.2|3 48.5 cMNgfb 
    18590Pdgfaplatelet derived growth factor, alpha5 G2|5 82.0 cMPdgfa 
    18643Pfn1profilin 111 B4|11 42.0 cMPfn1 
    19046Ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform5 B1Ppp1cb 
        Pkcb1 
    18803Plcg1phospholipase C, gamma 12 H2|2 92.0 cMPlcg1 
    19158Pscd2pleckstrin homology, Sec7 and coiled-coil domains 27 B4Pscd2 
    19244Ptp4a2protein tyrosine phosphatase 4a24 D2.3Ptp4a2 
    69908Rab3bRAB3B, member RAS oncogene family4 C7Rab3b 
    19342Rab4bRAB4B, member RAS oncogene family7 A3|7 7.4 cMRab4b 
    19744RhebRAS-homolog enriched in brain5 A3Rheb 
    19877Rock1Rho-associated coiled-coil containing protein kinase 118 A2Rock1 
    21926Tnftumor necrosis factor17 B1|17 19.06 cMTnf 
    17765Mtf2metal response element binding transcription factor 25 FMtf2 
    18515Pbx2pre B-cell leukemia transcription factor 217 B1Pbx2 
    21425Tcfebtranscription factor EB17 D|17 26.0 cMTcfeb 
    11941Atp2b2ATPase, Ca++ transporting, plasma membrane 26 E3|6 49.5 cMAtp2b2 
    53872Caprin1cell cycle associated protein 12 E2Gpiap1 
    15567Slc6a4solute carrier family 6 (neurotransmitter transporter, serotonin), member 411 B5|11 42.0 cMSlc6a4 
    71375Foxn3forkhead box N312 F1BC029185 
    216873Spag7sperm associated antigen 711 B4|11 42.0 cMSpag7 
    12531Cdc25bcell division cycle 25 homolog B (S. pombe)2 F1|2 73.9 cMCdc25b 
    245688Rbbp7retinoblastoma binding protein 7X F4Rbbp7 
    11501Adam8a disintegrin and metallopeptidase domain 87 F3-F5Adam8 
    100043024Tnxatenascin XA17 B1Tnxa 
    14433Gapdhglyceraldehyde-3-phosphate dehydrogenase6 F2Gapd 
        M27315 
    18746Pkm2pyruvate kinase, muscle9 B|9 52.0 cMPk3 
    20656Sod2superoxide dismutase 2, mitochondrial17 A1|17 7.6 cMSod2 
    14805Grik1glutamate receptor, ionotropic, kainate 116 C3.3|16 58.0 cMGrik1 
    319504Nrcamneuron-glia-CAM-related cell adhesion molecule12 B3Nrcam 
    18196Nsg1neuron specific gene family member 15 B3|5 21.0 cMNsg1 
        Prosap1 
    64051Sv2asynaptic vesicle glycoprotein 2 a3 F2Sv2a 
    20977SypsynaptophysinX A-D|X 1.5 cMSyp 
    12461Cct2chaperonin subunit 2 (beta)10 D2Cct2 
    19167Psma3proteasome (prosome, macropain) subunit, alpha type 312 C3Psma3 
    26441Psma4proteasome (prosome, macropain) subunit, alpha type 49 CPsma4 
    26442Psma5proteasome (prosome, macropain) subunit, alpha type 53 F3Psma5 
    19172Psmb4proteasome (prosome, macropain) subunit, beta type 43 F2|3 43.1 cMPsmb4 
    70247Psmd1proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 C5Psmd1 
    22200Uba3ubiquitin-like modifier activating enzyme 36 D3Ube1c 
    22258Usp4ubiquitin specific peptidase 4 (proto-oncogene)9 F2|9 60.0 cMUsp4 
    22284Usp9xubiquitin specific peptidase 9, X chromosomeX A1.1|X 5.5 cMUsp9x 
    60441Mrpl38mitochondrial ribosomal protein L3811 E2Mrpl38 
    19942Rpl27ribosomal protein L2711 A1Rpl27 
    26961Rpl8ribosomal protein L815 E1Rpl8 
    20091Rps3aribosomal protein S3a3 F1Rps3a 
    11512Adcy6adenylate cyclase 615 FAdcy6 
    11550Adra1dadrenergic receptor, alpha 1d2 F1|2 74.9 cMAdra1d 
    11652Akt2thymoma viral proto-oncogene 27 B1|7 6.5 cMAkt2 
    11841Arf2ADP-ribosylation factor 211 E1|11 62.0 cMArf2 
    11852Rhobras homolog gene family, member B12 A1.1Arhb 
    19055Ppp3caprotein phosphatase 3, catalytic subunit, alpha isoform3 G3Calna 
    52163Camk1calcium/calmodulin-dependent protein kinase I6 E3|6 48.7 cMCamk1 
    23991Cib1calcium and integrin binding 1 (calmyrin)7 D3Cib1 
    12801Cnr1cannabinoid receptor 1 (brain)4 A5|4 13.9 cMCnr1 
    93687Csnk1a1casein kinase 1, alpha 118 D3Csnk1a1 
    12995Csnk2a1casein kinase 2, alpha 1 polypeptide2 G3Csnk2a1 
    56431Dstndestrin2 H1|2 81.4 cMDstn 
    15200Hbegfheparin-binding EGF-like growth factor18 B2|18 15.0 cMDtr 
    14693Gnb2guanine nucleotide binding protein (G protein), beta 25 G2|5 76.0 cMGnb2 
    56637Gsk3bglycogen synthase kinase 3 beta16 B4Gsk3b 
    16476JunJun oncogene4 C5-C7|4 44.6 cMJun 
    26395Map2k1mitogen-activated protein kinase kinase 19 C|9 36.0 cMMap2k1 
    26921Map4k4mitogen-activated protein kinase kinase kinase kinase 4-Map4k4 
    26417Mapk3mitogen-activated protein kinase 37 F3|7 61.0 cMMapk3 
    30957Mapk8ip3mitogen-activated protein kinase 8 interacting protein 317 A3.3Mapk8ip3 
    17165Mapkapk5MAP kinase-activated protein kinase 55 FMapkapk5 
    234344Naf1nuclear assembly factor 1 homolog (S. cerevisiae)8 B3.3Naf1 
    18049Ngfnerve growth factor3 F2.2|3 48.5 cMNgfb 
    217166Nr1d1nuclear receptor subfamily 1, group D, member 111 DNr1d1 
    12305Ddr1discoidin domain receptor family, member 117 C|17 21.5 cMNtrk4 
    18590Pdgfaplatelet derived growth factor, alpha5 G2|5 82.0 cMPdgfa 
    18643Pfn1profilin 111 B4|11 42.0 cMPfn1 
    170835Pib5paphosphatidylinositol (4,5) bisphosphate 5-phosphatase, A11 A1Pib5pa 
        Pkcb1 
    18795Plcb1phospholipase C, beta 12 F3|2 76.7 cMPlcb1 
    19047Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform5 F-G1Ppp1cc 
    19158Pscd2pleckstrin homology, Sec7 and coiled-coil domains 27 B4Pscd2 
    59021Rab2aRAB2A, member RAS oncogene family4 A1Rab2 
    69908Rab3bRAB3B, member RAS oncogene family4 C7Rab3b 
    19353Rac1RAS-related C3 botulinum substrate 15 G2|5 82.0 cMRac1 
    19744RhebRAS-homolog enriched in brain5 A3Rheb 
    20111Rps6ka1ribosomal protein S6 kinase polypeptide 1-Rps6ka1 
    21928Tnfaip2tumor necrosis factor, alpha-induced protein 212 F1|12 56.0 cMTnfaip2 
    54343Atf7ipactivating transcription factor 7 interacting protein6 G1Atf7ip 
    17765Mtf2metal response element binding transcription factor 25 FMtf2 
    20024Sub1SUB1 homolog (S. cerevisiae)15 A2Rpo2tc1 
    21399Tcea1transcription elongation factor A (SII) 11 A1Tcea1 
    27224Tceb3transcription elongation factor B (SIII), polypeptide 34 D3Tceb3 
    21425Tcfebtranscription factor EB17 D|17 26.0 cMTcfeb 
    22278Usf1upstream transcription factor 11 H|1 93.3 cMUsf1 
    22632Yy1YY1 transcription factor12 F1|12 53.0 cMYy1 
    56188Fxyd1FXYD domain-containing ion transport regulator 17 B1Fxyd1 
    362911Mal2A 
    20266Scn1bsodium channel, voltage-gated, type I, beta7 B1|7 10.0 cMScn1b 
    277973Slc9a5solute carrier family 9 (sodium/hydrogen exchanger), member 58 D3Slc9a5 
    16527Kcnk3potassium channel, subfamily K, member 35 B|5 18.0 cMTask 
    52014Nus1nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)10 B3|10 29.0 cMBC018372 
    71375Foxn3forkhead box N312 F1BC029185 
    66877Crnkl1Crn, crooked neck-like 1 (Drosophila)2 G1Crn 
    58233Dnaja4DnaJ (Hsp40) homolog, subfamily A, member 49 A5.3Dnaja4