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Dataset Description
  • Dataset Name: 17295719
  • Species: Mouse
  • Method: Microarray
  • No. of Genes: 115
  • Tissue: Cultured fetal mouse cortical neurons
  • Phenotype: Ethanol response
  • Publication: Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
  • Dataset Summary: By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

    Gene list of this dataset (115 genes)
    Page: 1 2 3 list all   
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    12539Cdc37cell division cycle 37 homolog (S. cerevisiae)9 A3Cdc37 
    12540Cdc42cell division cycle 42 homolog (S. cerevisiae)4 D3|4 66.75 cMCdc42 
    51788H2afzH2A histone family, member Z3 G3H2afz 
    245688Rbbp7retinoblastoma binding protein 7X F4Rbbp7 
    109711Actn1actinin, alpha 112 C3|12 35.0 cMActn1 
    11502Adam9a disintegrin and metallopeptidase domain 9 (meltrin gamma)8 A2|8 8.0 cMAdam9 
    11804Aplp2amyloid beta (A4) precursor-like protein 29 A2-B|9 13.0 cMAplp2 
    22142Tuba1atubulin, alpha 1A15 F1|15 60.4 cMTuba1 
    17711CYTBcytochrome b, mitochondrial-Cytb 
    14104Fasnfatty acid synthase11 E2|11 72.0 cMFasn 
    140483Hnmthistamine N-methyltransferase2 A3Hnmt 
    18746Pkm2pyruvate kinase, muscle9 B|9 52.0 cMPk3 
    20656Sod2superoxide dismutase 2, mitochondrial17 A1|17 7.6 cMSod2 
    54393Gabbr1gamma-aminobutyric acid (GABA-B) receptor, 117 B1|17 20.4 cMGababr1 
    14800Gria2glutamate receptor, ionotropic, AMPA2 (alpha 2)3 E3|3 33.6 cMGria2 
    18196Nsg1neuron specific gene family member 15 B3|5 21.0 cMNsg1 
    18546Pcp4Purkinje cell protein 416 C4|16 69.9 cMPcp4 
        Prosap1 
    20977SypsynaptophysinX A-D|X 1.5 cMSyp 
    15511Hspa1bheat shock protein 1B17 B1|17 18.9 cMHsp70 
    15516Hsp90ab1heat shock protein 90kDa alpha (cytosolic), class B member 117 B3|17 15.0 cMHsp84 
    15481Hspa8heat shock protein 89 A5.1|9 24.0 cMHspa8 
    19172Psmb4proteasome (prosome, macropain) subunit, beta type 43 F2|3 43.1 cMPsmb4 
    19184Psmc5protease (prosome, macropain) 26S subunit, ATPase 511 E1Psmc5 
    22258Usp4ubiquitin specific peptidase 4 (proto-oncogene)9 F2|9 60.0 cMUsp4 
    22284Usp9xubiquitin specific peptidase 9, X chromosomeX A1.1|X 5.5 cMUsp9x 
    26961Rpl8ribosomal protein L815 E1Rpl8 
    20103Rps5ribosomal protein S57 A1Rps5 
    11350Abl1c-abl oncogene 1, receptor tyrosine kinase2 B|2 21.0 cMAbl1 
    11652Akt2thymoma viral proto-oncogene 27 B1|7 6.5 cMAkt2 
    19055Ppp3caprotein phosphatase 3, catalytic subunit, alpha isoform3 G3Calna 
    52163Camk1calcium/calmodulin-dependent protein kinase I6 E3|6 48.7 cMCamk1 
    56431Dstndestrin2 H1|2 81.4 cMDstn 
    15200Hbegfheparin-binding EGF-like growth factor18 B2|18 15.0 cMDtr 
    14365Fzd3frizzled homolog 3 (Drosophila)14 D1|14 27.0 cMFzd3 
    14693Gnb2guanine nucleotide binding protein (G protein), beta 25 G2|5 76.0 cMGnb2 
    56637Gsk3bglycogen synthase kinase 3 beta16 B4Gsk3b 
    227753Gsngelsolin2 B|2 24.5 cMGsn 
    26395Map2k1mitogen-activated protein kinase kinase 19 C|9 36.0 cMMap2k1 
    26406Map3k3mitogen-activated protein kinase kinase kinase 311 E1Map3k3 
    26417Mapk3mitogen-activated protein kinase 37 F3|7 61.0 cMMapk3 
    17118Marcksmyristoylated alanine rich protein kinase C substrate10 B1|10 22.0 cMMarcks 
    17330Minpp1multiple inositol polyphosphate histidine phosphatase 119 C1|19 35.0 cMMinpp1 
        Mustcratf 
    18049Ngfnerve growth factor3 F2.2|3 48.5 cMNgfb 
    18590Pdgfaplatelet derived growth factor, alpha5 G2|5 82.0 cMPdgfa 
    18643Pfn1profilin 111 B4|11 42.0 cMPfn1 
    19046Ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform5 B1Ppp1cb 
        Pkcb1 
    18803Plcg1phospholipase C, gamma 12 H2|2 92.0 cMPlcg1 
    Page: 1 2 3 list all