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Dataset Description
  • Dataset Name: 17295719
  • Species: Mouse
  • Method: Microarray
  • No. of Genes: 115
  • Tissue: Cultured fetal mouse cortical neurons
  • Phenotype: Ethanol response
  • Publication: Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
  • Dataset Summary: By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

    Gene list of this dataset (115 genes)
    Page: 1 2 3 list all   
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    12801Cnr1cannabinoid receptor 1 (brain)4 A5|4 13.9 cMCnr1 
    93687Csnk1a1casein kinase 1, alpha 118 D3Csnk1a1 
    12995Csnk2a1casein kinase 2, alpha 1 polypeptide2 G3Csnk2a1 
    56431Dstndestrin2 H1|2 81.4 cMDstn 
    15200Hbegfheparin-binding EGF-like growth factor18 B2|18 15.0 cMDtr 
    14693Gnb2guanine nucleotide binding protein (G protein), beta 25 G2|5 76.0 cMGnb2 
    56637Gsk3bglycogen synthase kinase 3 beta16 B4Gsk3b 
    16476JunJun oncogene4 C5-C7|4 44.6 cMJun 
    26395Map2k1mitogen-activated protein kinase kinase 19 C|9 36.0 cMMap2k1 
    26921Map4k4mitogen-activated protein kinase kinase kinase kinase 4-Map4k4 
    26417Mapk3mitogen-activated protein kinase 37 F3|7 61.0 cMMapk3 
    30957Mapk8ip3mitogen-activated protein kinase 8 interacting protein 317 A3.3Mapk8ip3 
    17165Mapkapk5MAP kinase-activated protein kinase 55 FMapkapk5 
    234344Naf1nuclear assembly factor 1 homolog (S. cerevisiae)8 B3.3Naf1 
    18049Ngfnerve growth factor3 F2.2|3 48.5 cMNgfb 
    217166Nr1d1nuclear receptor subfamily 1, group D, member 111 DNr1d1 
    12305Ddr1discoidin domain receptor family, member 117 C|17 21.5 cMNtrk4 
    18590Pdgfaplatelet derived growth factor, alpha5 G2|5 82.0 cMPdgfa 
    18643Pfn1profilin 111 B4|11 42.0 cMPfn1 
    170835Pib5paphosphatidylinositol (4,5) bisphosphate 5-phosphatase, A11 A1Pib5pa 
        Pkcb1 
    18795Plcb1phospholipase C, beta 12 F3|2 76.7 cMPlcb1 
    19047Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform5 F-G1Ppp1cc 
    19158Pscd2pleckstrin homology, Sec7 and coiled-coil domains 27 B4Pscd2 
    59021Rab2aRAB2A, member RAS oncogene family4 A1Rab2 
    69908Rab3bRAB3B, member RAS oncogene family4 C7Rab3b 
    19353Rac1RAS-related C3 botulinum substrate 15 G2|5 82.0 cMRac1 
    19744RhebRAS-homolog enriched in brain5 A3Rheb 
    20111Rps6ka1ribosomal protein S6 kinase polypeptide 1-Rps6ka1 
    21928Tnfaip2tumor necrosis factor, alpha-induced protein 212 F1|12 56.0 cMTnfaip2 
    54343Atf7ipactivating transcription factor 7 interacting protein6 G1Atf7ip 
    17765Mtf2metal response element binding transcription factor 25 FMtf2 
    20024Sub1SUB1 homolog (S. cerevisiae)15 A2Rpo2tc1 
    21399Tcea1transcription elongation factor A (SII) 11 A1Tcea1 
    27224Tceb3transcription elongation factor B (SIII), polypeptide 34 D3Tceb3 
    21425Tcfebtranscription factor EB17 D|17 26.0 cMTcfeb 
    22278Usf1upstream transcription factor 11 H|1 93.3 cMUsf1 
    22632Yy1YY1 transcription factor12 F1|12 53.0 cMYy1 
    56188Fxyd1FXYD domain-containing ion transport regulator 17 B1Fxyd1 
    362911Mal2A 
    20266Scn1bsodium channel, voltage-gated, type I, beta7 B1|7 10.0 cMScn1b 
    277973Slc9a5solute carrier family 9 (sodium/hydrogen exchanger), member 58 D3Slc9a5 
    16527Kcnk3potassium channel, subfamily K, member 35 B|5 18.0 cMTask 
    52014Nus1nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)10 B3|10 29.0 cMBC018372 
    71375Foxn3forkhead box N312 F1BC029185 
    66877Crnkl1Crn, crooked neck-like 1 (Drosophila)2 G1Crn 
    58233Dnaja4DnaJ (Hsp40) homolog, subfamily A, member 49 A5.3Dnaja4 
    Page: 1 2 3 list all